Surendra Kumar Saini

ORCID: 0000-0001-5869-8040
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About
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Research Areas
  • Advanced machining processes and optimization
  • Advanced Surface Polishing Techniques
  • Advanced Photocatalysis Techniques
  • Advanced Machining and Optimization Techniques
  • Neuropeptides and Animal Physiology
  • Laser Material Processing Techniques
  • Receptor Mechanisms and Signaling
  • Manufacturing Process and Optimization
  • Breast Cancer Treatment Studies
  • Additive Manufacturing Materials and Processes
  • Neurotransmitter Receptor Influence on Behavior
  • Carbon and Quantum Dots Applications
  • Pharmacological Receptor Mechanisms and Effects
  • Head and Neck Cancer Studies
  • Multicomponent Synthesis of Heterocycles
  • Corrosion Behavior and Inhibition
  • Lung Cancer Treatments and Mutations
  • CO2 Reduction Techniques and Catalysts
  • Quantum Dots Synthesis And Properties
  • Endometrial and Cervical Cancer Treatments
  • Sulfur-Based Synthesis Techniques
  • Nanocluster Synthesis and Applications
  • Synthesis and Biological Evaluation
  • Cervical Cancer and HPV Research
  • Welding Techniques and Residual Stresses

University of Rajasthan
2021-2025

DR. B.R.A. Institute Rotary Cancer Hospital
2024-2025

All India Institute of Medical Sciences
2021-2025

Indian Institute of Technology Roorkee
2020-2025

Indira Gandhi National Tribal University
2025

Poornima University
2021-2024

University of Namibia
2024

All India Institute of Medical Sciences Raipur
2021-2024

All India Institute of Medical Sciences Bhopal
2021-2024

Malaviya National Institute of Technology Jaipur
2017-2024

In the search for opioid ligands with mixed functional activity, a series of 5'-(4-chlorophenyl)-4,5α-epoxypyridomorphinans possessing alkoxy or acyloxy groups at C-14 was synthesized and evaluated. this series, affinity activity were found to be influenced by nature substituent as well N-17. Whereas incorporation 3-phenylpropoxy group on N-methylpyridomorhinan gave dual MOR agonist/DOR agonist 17h, its N-cyclopropylmethylpyridomorphinan antagonist 17d. Interestingly, 17d, in contrast did...

10.1021/jm300686p article EN Journal of Medicinal Chemistry 2012-09-27

Despite the modern boost, developing a new photocatalytic system for reduction of aldehydes is still challenging due to their high negative potential. Herein, we have used metal-free photoinduced electron-transfer based on cheap and readily available organic dye eosin Y (EY), graphene oxide (GO), ammonium oxalate (AO) structurally diverse under sustainable conditions. The protocol shows remarkable selectivity over ketones. decisive interaction GO AO with various states EY (ground, singlet,...

10.1021/acsami.2c21235 article EN ACS Applied Materials & Interfaces 2023-01-26

10.1016/j.jmapro.2019.06.017 article EN Journal of Manufacturing Processes 2019-06-25

Carcinoma of the oesophagus ranks seventh in incidence (572,000 new cases) and sixth overall mortality worldwide (509,000 deaths). Esophageal cancer was, fact, responsible for an estimated one every 20. The most common histological variant was Squamous Cell (SCC) conventionally. Management this disease includes all three primary modalities treatment: surgery, chemotherapy radiotherapy. In present case, a 75-year-old female patient diagnosed with SCC Esophagus, she did not want to take...

10.46607/iamj17p9022025 article EN International Ayurvedic Medical Journal 2025-01-14

Breast cancer is the most common malignancy diagnosed in women worldwide. Triple-negative breast (TNBC) aggressive subtype, accounting for nearly one third of all cancers India. The addition pembrolizumab to neoadjuvant chemotherapy improved pathological response and event free survival patients with TNBC. However, low- middle-income countries, immunotherapy remains inaccessible due its high cost. Pharmacological early clinical data suggest that a lower dose may be effective. there are no...

10.1186/s13063-025-08726-9 article EN cc-by-nc-nd Trials 2025-02-27

A series of pyrido- and pyrimidomorphinans (6a−h 7a−g) were synthesized from naltrexone evaluated for binding biological activity at the opioid receptors. The unsubstituted pyridine 6a displayed high affinities δ, μ, κ receptors with Ki values 0.78, 1.5, 8.8 nM, respectively. Compound was devoid agonist in mouse vas deferens (MVD) guinea pig ileum (GPI) preparations but found to display moderate weak antagonist MVD GPI Ke 37 164 general lower potencies δ receptor selectivities than their...

10.1021/jm990039i article EN Journal of Medicinal Chemistry 1999-08-19

Antagonist and partial agonist modulators of the dopamine D3 receptor (D3R) have emerged as promising therapeutics for treatment substance abuse neuropsychiatric disorders. However, development druglike lead compounds with selectivity has been challenging because high sequence homology between D3R D2 (D2R). In this effort, we synthesized a series acylaminobutylpiperazines incorporating aza-aromatic units evaluated their binding functional activities at receptors. Docking studies results from...

10.1021/jm500801r article EN publisher-specific-oa Journal of Medicinal Chemistry 2014-08-15

Herein, we demonstrate a simple, reproducible, and environment-friendly strategy for the synthesis of carbon quantum dots (CQDs) utilizing mango (Mangifera indica) kernel as renewable green source. Various analytical tools characterized as-prepared CQDs. These fluorescent CQDs showed significant water solubility with uniform size about 6 nm. The as-synthesized show significantly enhanced catalytic activity production α,β-unsaturated compounds from derivatives aromatic alkynes aldehydes under...

10.1039/d2ra05201f article EN cc-by-nc RSC Advances 2022-01-01

Despite the fact that carbon quantum dots (CQDs) have significant catalytic potential, only emblematic applications rely on simple acid-base or hydrogen-bonding activation pathways been reported. In this study, natural amine-targeted CQDs (NAT-CQDs) successfully fabricated using a sustainable technique harnesses renewable green source. Based holistic assessment, present approach for synthesis of NAT-CQDs surpasses previously reported methods in terms estimated circular and...

10.1021/acsami.3c08812 article EN ACS Applied Materials & Interfaces 2023-10-11

Rational design and precise synthesis of biogenic noble-metal-based catalysts possessing distinctive structure composition play a crucial role in the chemical industry, enabling sustainable construction an inclusive range resources. In this study, we have effectively fabricated Pd@A-CQDs through straightforward one-pot aqueous protocol assisted by visible light employing renewable biomass-derived amine-rich carbon quantum dots (A-CQDs). The remarkable harnessing capability (bandgap, ca. 2.81...

10.1021/acsami.4c04739 article EN ACS Applied Materials & Interfaces 2024-08-21
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