A5015931509- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bee Products Chemical Analysis
- COVID-19 Clinical Research Studies
- Medical Imaging Techniques and Applications
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Healthcare and Venom Research
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Phytochemicals and Medicinal Plants
- Advanced biosensing and bioanalysis techniques
- Vibrio bacteria research studies
- Phytochemicals and Antioxidant Activities
- Tuberculosis Research and Epidemiology
- Carbon and Quantum Dots Applications
- Radiopharmaceutical Chemistry and Applications
- Erythrocyte Function and Pathophysiology
- RNA and protein synthesis mechanisms
- Natural Antidiabetic Agents Studies
- Advanced Radiotherapy Techniques
- Chromosomal and Genetic Variations
- Phagocytosis and Immune Regulation
- Bacterial Genetics and Biotechnology
Indian Institute of Technology Roorkee
2019-2025
Stanford University
2022-2024
Endocrinology Research Center
2021
In this work, a new nanocomposite (Ag@S-GQDs) have been synthesized using one-step facile synthesis process and their antibacterial as well cytotoxicity properties were investigated systematically.
Background The outbreak of the novel coronavirus disease COVID-19, caused by SARS-CoV-2 virus has spread rapidly around globe during past 3 months. As infected cases and mortality rate this is increasing exponentially, scientists researchers all over world are relentlessly working to understand new along with possible treatment regimens discovering active therapeutic agents vaccines. So, there an urgent requirement effective medications that can treat SARS-CoV-2. Methods findings We perform...
In this study, we have examined the effect of ligand substituent on structure-cytotoxicity relationships MCF-7 cancer cell line (human breast cancer), by two copper(ii) complexes {[Cu(qmbn)(Hqmba)(q)]·NO3·2H2O} (1) and {[Cu(Hqmba)2(q)]·NO3·2H2O} (2) (where, qmbn = 2-(quinolin-8-yloxy)(methyl) benzonitrile (L1); Hqmba 2-((quinolin-8-yloxy)methyl)benzoic acid (L2) q quinolin-8-olate). The structural analysis reveals that both exhibit distorted octahedral (CuN3O3) configuration which is further...
Many traditional treatments include honey owing to its magnificent health beneficiary effects.
ABSTRACT Background The outbreak of the novel coronavirus disease COVID-19, caused by SARS-CoV-2 virus has spread rapidly around globe during past 3 months. As infected cases and mortality rate this is increasing exponentially, scientists researchers all over world are relentlessly working to understand new along with possible treatment regimens discovering active therapeutic agents vaccines. So, there an urgent requirement effective medications that can treat SARS-CoV-2. Methods findings We...
Various metal–organic frameworks of Zn(<sc>ii</sc>) and Cd(<sc>ii</sc>) have been synthesized hydrothermally for the detection herbicide (simazine) as well nitro-aromatic compounds. Also these MOFs show live-cell imaging MCF-7 cells.
In vivo molecular imaging tools are crucially important for elucidating how cells move through complex biological systems; however, achieving single-cell sensitivity over the entire body remains challenging. Here, we report a highly sensitive and multiplexed approach tracking upward of 20 single simultaneously in same subject using positron emission tomography (PET). The method relies on statistical algorithm (PEPT-EM) to achieve 4 becquerel per cell streamlined workflow reliably label with...
Positron emission tomography (PET), a cornerstone in cancer diagnosis and treatment monitoring, relies on the enhanced uptake of fluorodeoxyglucose ([
Simple and efficient method was established for the synthesis of a new family 14α-O-(andrographolide-3-subsitutedisoxazole-5-carboxylate) derivatives (10a-j) from naturally occurring andrographolide (1) by selective esterification with propiolic acid at C-14 using protection deprotection strategy followed metal free 1,3-dipolar cycloaddition aryl nitrile oxides. All synthesised were tested their cytotoxicity against HCT-15, HeLa DU145 cell lines. Most compounds exhibited improved cytotoxic...
Background Diagnosis of TB in pediatric population poses several challenges. A novel initiative was implemented major cities India aimed at providing upfront access to free-of-cost Xpert MTB/RIF presumptive cases. This paper aims describe the experience implementing this large and assess feasibility intervention high burden settings. Methods Data were drawn from project 10 between April 2014 March 2018. In each city, providers, both public private, engaged linked with a throughput lab...
Chimaphila umbellata (CU) is a small perennial plant whose roots and leaves are used in the preparation of homeopathic medicines. In this study, anti-proliferative apoptotic effects CU extract, obtained from its mother tincture, were evaluated human breast cancer cell lines. MTT assay was to evaluate dose- time-dependent cytotoxicity extract MCF-7 HEK293 cells. The effect using clonogenic wound healing assays. anti-angiogenic activity drug chick chorioallantoic membrane assay. mode death...
Colon cancer is the most prevalent cause of death from across globe. Although chemotherapy drugs are predominantly used, their toxicity always remains a concern. As an alternative to synthetic drugs, natural compounds or nutraceuticals comparatively less toxic. Honey widely used different cultures as form medicine. It represents prominent source plant-phenolic and there demonstrable evidence its anti-oxidant anti-microbial activities. The aim present work was investigate anti-proliferative...
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for an immediate search novel treatment strategies. Recently, BlaC, the principal beta-lactamase Mycobacterium tuberculosis, was recognized as a potential therapeutic target. BlaC belongs to Ambler class A, which is generally susceptible inhibitors currently used in clinics: tazobactam, sulbactam, clavulanate. Alterations at Ser130 conserved SDN loop confer resistance mechanism-based (MBIs)...
β-lactamase production with vast catalytic divergence in the pathogenic strain limits antibiotic spectrum clinical environment. Class A carbapenemase shares significant sequence similarities, structural features, and common mechanisms although their resistance differs from class carbapenem monobactam hydrolysis. In other words, it limited treatment option against infection, causing carbapenemase-producing superbugs. Ftu-1 is a expressed by Francisella tularensis strain, potent causative...