A5113106447- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Effects of Radiation Exposure
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- DNA Repair Mechanisms
- Cancer-related cognitive impairment studies
- Cancer-related molecular mechanisms research
- COVID-19 and Mental Health
- Blood groups and transfusion
- Brain Metastases and Treatment
- Optical Imaging and Spectroscopy Techniques
- Nursing education and management
- Gastrointestinal Tumor Research and Treatment
- Breast Cancer Treatment Studies
- Molecular Communication and Nanonetworks
- Radiation Dose and Imaging
- Nuclear Physics and Applications
Stanford University
2022-2025
Stratford University
2024
Stanford Medicine
2023
We describe a multicenter cross validation of ultra-high dose rate (UHDR) (>= 40 Gy/s) irradiation in order to bring dosimetric consensus absorbed water. UHDR refers rates over 100-1000 times those conventional clinical beams. irradiations have been topic intense investigation as they reported induce the FLASH effect which normal tissues exhibit reduced toxicity relative rates. The need establish optimal beam parameters capable achieving vivo has become paramount. It is therefore necessary...
Abstract Purpose Ultra-high dose-rate radiotherapy (FLASH) has been shown to mitigate normal tissue toxicities associated with conventional dose rate (CONV) without compromising tumor killing in preclinical models. A prominent challenge radiation research, including FLASH, is validating both the physical dosimetry and biological effects across multiple institutions. Methods We previously demonstrated dosimetric reproducibility of two different electron FLASH devices at separate institutions...
Blood products, including apheresis platelets and plasma, are essential for medical use but pose risks of bacterial contamination viral transmission. Platelets prone to growth due their storage conditions, while plasma requires extensive screening. This study explores rapid irradiation as an innovative pathogen reduction method. A clinical linear accelerator was configured deliver ultra-high dose rate (6 kGy/min) platelet components. spiked with Escherichia coli (E. coli; 10⁵ colony-forming...
Introduction: Radiotherapy is effective for breast cancer treatment but often causes undesirable side effects that impair quality of life. Ultra-high dose rate radiotherapy (FLASH) has shown reduced normal tissue toxicity while achieving comparable tumor growth delay compared to conventional (CONV). This study evaluated whether FLASH could achieve similar control as CONV with eradication the primary endpoint, in an orthotopic model. Methods: Non-metastatic, tumors were generated left fourth...
Abstract The complementarity and clinical utility of combining liquid biopsies radiomic image analysis has not been demonstrated. ctDNA minimal residual disease after chemoradiotherapy (CRT) for non–small cell lung cancer (NSCLC) is highly prognostic, but on-treatment biomarkers are needed to enable response-adapted therapies. In this study, we analyzed 418 patients with NSCLC undergoing CRT develop validate a novel dynamic risk model that accurately predicts ultimate progression-free...
Abstract Background FLASH radiation therapy (RT) offers a promising avenue for the broadening of therapeutic index. However, to leverage full potential in clinical setting, an improved understanding biological principles involved is critical. This requires availability specialized equipment optimized delivery conventional (CONV) and ultra‐high dose rate (UHDR) irradiation preclinical studies. One method conduct such radiobiological research involves adapting linear accelerator configured...
Despite radiation therapy (RT) and surgery being the curative treatments, prior work demonstrated that aggregated Asian American (AA) Native Hawaiian Other Pacific Islanders (NHPI) population refuse RT at a higher rates than other races. Given AA NHPI are distinct groups, data disaggregation is necessary to understand racial ethnic disparities for treatment refusal. We aimed (1) compare refusal between populations, (2) assess on overall mortality, (3) determine predictors of refusing using...
Abstract Radiation therapy, one of the most effective therapies to treat cancer, is highly toxic healthy tissue. The delivery radiation at ultra-high dose rates, FLASH therapy (FLASH), has been shown maintain therapeutic anti-tumor efficacy while sparing normal tissues compared conventional rate irradiation (CONV). Though promising, these studies have limited mainly murine models. Here, we leveraged enteroids, three-dimensional cell clusters that mimic intestine, study human-specific tissue...
The molecular and cellular mechanisms driving the enhanced therapeutic ratio of ultra-high dose-rate radiotherapy (FLASH-RT) over slower conventional (CONV-RT) remain to be elucidated. However, attenuated DNA damage transient oxygen depletion are among several proposed models. Here, we tested whether FLASH-RT under physioxic (4% O 2 ) hypoxic conditions (≤2% reduces genome-wide translocations relative CONV-RT any differences identified revert normoxic (21% conditions. We employed...
Abstract Blood-based liquid biopsies enable non-invasive characterization of cancers. Cell-free RNA (cfRNA) analysis could potentially complement circulating tumor DNA (ctDNA) and allow broader molecular cancers but has not been extensively explored. Here, we describe RARE-Seq, a novel cfRNA sequencing method designed to maximize sensitivity by targeting rare, tissue-specific transcripts, simultaneously detecting both tumor-derived expression signatures somatic mutations in (ctRNA). To...
ABSTRACT BACKGROUND AND OBJECTIVES Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination viral transmission. Platelet vulnerable to bacterial due storage conditions, while requires extensive screening minimize virus transmission risks. Here we investigate rapid irradiation sterilizing doses bacteria viruses as an innovative pathogen reduction technology. MATERIALS METHODS We configured a clinical...
ABSTRACT Purpose Radiotherapy is an effective breast cancer treatment that enhances local tumor control and prolongs overall survival yet associated with undesirable side effects which can impair quality of life. Ultra-high dose rate radiotherapy (FLASH) has been shown to induce less normal tissue toxicity while producing comparable growth delay in a variety preclinical models when compared conventional (CONV). However, not surrogate for eradication, critical endpoint therapy, studies using...