A5053103486- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Effects of Radiation Exposure
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Genomics, phytochemicals, and oxidative stress
- Hepatocellular Carcinoma Treatment and Prognosis
- Management of metastatic bone disease
- Renal Transplantation Outcomes and Treatments
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Ultrasound and Hyperthermia Applications
- Telemedicine and Telehealth Implementation
- Glutathione Transferases and Polymorphisms
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Lymphocytic Leukemia Research
Stanford University
2018-2024
Washington University in St. Louis
2024
Cancer Institute (WIA)
2024
Stanford Cancer Institute
2018-2023
Oakland University
2021-2023
Stanford Medicine
2023
Retina Specialists of Michigan
2022
Beaumont Health
2022
Mayo Clinic Hospital
2020
Stratford University
2020
Circulating tumor DNA (ctDNA) molecular residual disease (MRD) following curative-intent treatment strongly predicts recurrence in multiple types, but whether further can improve outcomes patients with MRD remains unclear. We applied CAPP-Seq ctDNA analysis to 218 samples from 65 receiving chemoradiation therapy (CRT) for locally advanced NSCLC, including 28 consolidation immune checkpoint inhibition (CICI). Patients undetectable after CRT had excellent or not they received CICI. Among such...
Abstract Radiation therapy is the most effective cytotoxic for localized tumors. However, normal tissue toxicity limits radiation dose and curative potential of when treating larger target volumes. In particular, highly radiosensitive intestine use patients with intra-abdominal metastatic ovarian cancer, total abdominal irradiation (TAI) was used as an postsurgical adjuvant in management metastases. TAI fell out favor due to high intestine. Here we utilized innovative preclinical platform...
Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations mutations with outcome. Here, we analyze 232 consecutive patients NSCLC and demonstrate that KEAP1 NFE2L2 are predictive high rates local recurrence (LR) after radiotherapy but surgery. Half LRs occurred tumors KEAP1/NFE2L2 mutations, indicating they major molecular drivers clinical radioresistance. Next, functionally evaluate our cohort only pathogenic associated...
Radiation therapy, along with surgery and chemotherapy, is one of the main treatments for cancer. While radiotherapy highly effective in treatment localized tumors, its limitation toxicity to normal tissue. Previous preclinical studies have reported that ultra-high dose-rate (FLASH) irradiation results reduced tissues while controlling tumor growth a similar extent relative conventional-dose-rate (CONV) irradiation. To our knowledge this first report dose-response study mice comparing effect...
Treatment with PD-(L)1 blockade can produce remarkably durable responses in patients non-small cell lung cancer (NSCLC). However, a significant fraction of long-term responders ultimately progress and predictors late progression are unknown. We hypothesized that circulating tumor DNA (ctDNA) analysis to may differentiate those who will achieve ongoing benefit from at risk eventual progression.In advanced NSCLC achieving (progression-free survival ≥ 12 months), plasma was collected...
Abstract Cerebrospinal fluid tumor-derived DNA (CSF-tDNA) analysis is a promising approach for monitoring the neoplastic processes of central nervous system. We applied lung cancer-specific sequencing panel (CAPP-Seq) to 81 CSF, blood, and tissue samples from 24 cancer patients who underwent lumbar puncture (LP) suspected leptomeningeal disease (LMD). A subset cohort ( N = 12) participated in prospective trial osimertinib refractory LMD which serial LPs were performed before during...
Abstract Peritoneal metastases are the leading cause of morbidity and mortality in ovarian cancer. Despite current surgery, chemotherapy targeted therapies, majority patients diagnosed with advanced epithelial cancer develop recurrent disease overall survival rates remain poor. It is known that a radiosensitive tumor. Historically, total abdominal irradiation (TAI) was used as an effective postsurgical adjuvant therapy management sensitive resistant However, TAI fell out favor due to high...
Abstract Background FLASH radiation therapy (RT) offers a promising avenue for the broadening of therapeutic index. However, to leverage full potential in clinical setting, an improved understanding biological principles involved is critical. This requires availability specialized equipment optimized delivery conventional (CONV) and ultra‐high dose rate (UHDR) irradiation preclinical studies. One method conduct such radiobiological research involves adapting linear accelerator configured...
The aim of this study was to report local failure (LF) outcomes and associated predictors in patients with oligometastatic colorectal cancer (CRC) treated stereotactic ablative radiotherapy (SABR).We retrospectively reviewed CRC metastases the brain, liver, spine, or lung SABR between 2001 2016. Time LF summarized using cumulative incidence curves death as a competing risk.The analysis included total 130 256 lesions. Of treated, 129 (50%) were 50 (20%) 49 (19%) 28 (11%) lung. Median gross...
In response to the COVID-19 pandemic, neurosurgical outpatient practices have rapidly adopted telemedicine services meet needs of patients. To date, patient satisfaction with in neurosurgery, setting has not been evaluated a validated survey. Patients that completed (phone or video) visits (new, return, postoperative visits) neurosurgery clinic from June 1, 2020 August 15, were queried portion Press Ganey® (PG) Survey questions related care provider. For each question, was defined as score 4...
The observation of an enhanced therapeutic index for FLASH radiotherapy in mice has created interest practical laboratory-based irradiators. To date, systems capable 3D conformal irradiation have been lacking. We are developing such a system, incorporating high-current linear accelerator to produce collimated X-ray beam stationary beamline design, rotating the mouse about longitudinal axis achieve from multiple directions. purpose this work was evaluate reproducibility anatomy under rotation...
Abstract Radiation therapy is the most effective cytotoxic cancer available for treatment of localized tumors. However, radiation-induced toxicity to normal tissues limits radiation dose and therefore curative potential radiotherapy. In particular, highly radiosensitive intestine greatly use patients with intra-abdominal tumor diseases including women ovarian cancer. Here we sought investigate safety efficacy FLASH in widespread peritoneal metastases. We performed abdominal irradiation on...
Central retinal vein occlusion (CRVO) typically manifests as unilateral vision loss from thrombosis and of the central in patients with thrombophilic risk factors. Here we report a case 23-year-old male three weeks intermittent left-sided eye pressure loss, who was found to have decreased visual acuity, hemorrhages, an impending CRVO his left eye. Upon further evaluation, infectious disease autoimmune labs were normal, but he had mildly increased right heart pressures hypercoagulable changes...
Abstract Introduction Cerebrospinal fluid tumor-derived DNA (CSF-tDNA) analysis is a promising approach for monitoring neoplastic processes of the central nervous system. We hypothesize that CSF-tDNA in patients with advanced lung cancer improves sensitivity leptomeningeal disease (LMD) diagnosis and enables system response monitoring. Methods applied CAPP-Seq using cancer-specific sequencing panel to 81 CSF, blood, tissue samples from 24 who underwent lumbar puncture (LP) suspected LMD. A...
Objective The 2-year incidence of brain metastases (BrMs) in stage III non-small lung cell cancer (NSCLC) has been estimated to be around 30%. However, recent clinical trials have demonstrated considerably lower BrMs rates this patient population. In study, we aimed review the real-world incidence, surveillance, and treatment patterns NSCLC. Materials methods Using a retrospective single-center study design, identified patients with NSCLC who received radiation curative intent over 10-year...
<div>AbstractPurpose:<p>Treatment with PD-(L)1 blockade can produce remarkably durable responses in patients non–small cell lung cancer (NSCLC). However, a significant fraction of long-term responders ultimately progress and predictors late progression are unknown. We hypothesized that circulating tumor DNA (ctDNA) analysis to may differentiate those who will achieve ongoing benefit from at risk eventual progression.</p>Experimental Design:<p>In advanced NSCLC...
Abstract Purpose As C‐arm linac radiation therapy evolves toward faster, more efficient delivery, and conformal dosimetry, treatments with increasingly complex couch motions are emerging. Monitoring the patient motion independently of during non‐coplanar, non‐isocentric, or dynamic is a key bottleneck to their clinical implementation. The goal this study develop prototype real‐time monitoring system for unconventional beam trajectories ensure safe accurate treatment delivery. Methods An...
Introduction:Anterior lumbar interbody fusion (ALIF) is used to treat spondylosis and spondylolisthesis.The operation involves an anterior, retroperitoneal approach the spine.Patients frequently experience a slow return of bowel function secondary anesthetic time, opioid use, primarily due displacement intraoperatively; however, this amenable outpatient surgery.Gum chewing decreases time for (RBF) in postoperative colorectal gynecology patients.Despite data, association between gum RBF has...