A5071069095- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- 3D Printing in Biomedical Research
- Meningioma and schwannoma management
- ATP Synthase and ATPases Research
- Spinal Fractures and Fixation Techniques
- Management of metastatic bone disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
Stanford University
2016-2025
Stratford University
2023-2025
Stanford Medicine
2015-2025
Mayo Clinic
2024
Palo Alto University
2020-2024
Neurological Surgery
2011-2021
Stanford Cancer Institute
2013-2021
University College Dublin
2020
Oxford University Press (United Kingdom)
2020
Northwestern University
2018
Significance Microglia are the tissue resident macrophages of brain and spinal cord, implicated in important developmental, homeostatic, disease processes, although our understanding their roles is complicated by an inability to distinguish microglia from related cell types. Although they share many features with other macrophages, have distinct developmental origins functions. Here we validate a stable robustly expressed microglial marker for both mouse human, transmembrane protein 119...
Significance The brain comprises an immense number of cells and cellular connections. We describe the first, to our knowledge, single cell whole transcriptome analysis human adult cortical samples. have established experimental analytical framework with which complexity can be dissected on level. Using this approach, we were able identify all major types characterize subtypes neuronal cells. observed changes in neurons from early developmental late differentiated stages adult. found a subset...
Glioblastoma (GBM) is the most common primary brain cancer in adults and notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq) on 3,589 cells a cohort four patients. obtained from tumor core as well surrounding peripheral tissue. Our analysis revealed cellular variation tumor's genome transcriptome. were also able identify infiltrating neoplastic regions lesions. Despite existence significant heterogeneity among cells, we found that...
Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor patients is challenging, presumably owing to blood-brain barrier. Cerebral spinal fluid (CSF) may serve as an alternative "liquid biopsy" tumors by enabling measurement circulating within CSF characterize tumor-specific mutations. Many aspects about characteristics and detectability mutations remain undetermined.We used digital PCR targeted amplicon sequencing quantify cfDNA plasma collected from 7 with solid tumors....
This cohort study assesses the association of COVID-19 pandemic with incidence 5 medical emergencies (acute myocardial infarction, ischemic stroke, nontraumatic subarachnoid hemorrhage, ectopic pregnancy, and appendicitis) in 2 US academic centers.
Single-session stereotactic radiosurgery (SRS) treatment of vestibular schwannomas results in excellent tumor control. It is not known whether functional outcomes can be improved by fractionating the over multiple sessions.To examine control and complication rates after multisession SRS.Three hundred eighty-three patients treated with SRS from 1999 to 2007 at Stanford University Medical Center were retrospectively reviewed. Ninety percent 18 Gy 3 sessions, targeting a median volume 1.1 cm3...
The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that Neuropilin 1 (Nrp1) Nrp2, transmembrane proteins with roles axon guidance vascular endothelial growth factor (VEGF) signaling, are important positive regulators of signal transduction. Nrps expressed at times locations active transduction during mouse development. Using cell lines lacking key components, mediate between activated...
In contrast to sagittal craniosynostosis, the role of endoscopic, minimally invasive approaches in treatment metopic craniosynostosis with resulting trigonocephaly is not as well defined. We reviewed senior authors' (H.M. and S.C.) clinical experience children using a variety endoscopic open techniques. Thirty-three patients were treated at single institution during 5-year period between 3 8 years follow-up. Sixteen underwent variations approaches, 17 had fronto-orbital advancement. Clinical...
Central nervous system tumors carry grave clinical prognoses due to limited effectiveness of surgical resection, radiation, and chemotherapy. Thus, improved strategies for brain tumor visualization targeted treatment are critically needed. We demonstrate that mouse cerebellar medulloblastoma (MB) can be illuminated with a fluorescent, engineered cystine knot (knottin) peptide binds high affinity αvβ3, αvβ5, α5β1 integrin receptors. This integrin-binding knottin peptide, denoted EETI 2.5F,...
Abstract Background We sought to determine the maximum tolerated dose (MTD) of 5-fraction stereotactic radiosurgery (SRS) with 5-mm margins delivered concurrent temozolomide in newly diagnosed glioblastoma (GBM). Methods enrolled adult patients 5 days SRS a 3 + design on 4 escalating levels: 25, 30, 35, and 40 Gy. Dose limiting toxicity (DLT) was defined as Common Terminology Criteria for Adverse Events grades 3–5 acute or late CNS toxicity, including adverse radiation effect (ARE), imaging...
: First-line therapy for high-grade gliomas (HGGs) includes maximal safe surgical resection. The extent of resection predicts overall survival, but current neuroimaging approaches lack tumor specificity. epidermal growth factor receptor (EGFR) is a highly expressed HGG biomarker. We evaluated the safety and feasibility an anti-EGFR antibody, panitumuab-IRDye800, at subtherapeutic doses as imaging agent HGG.