A5083322184- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Voice and Speech Disorders
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Breast Implant and Reconstruction
- Molecular Biology Techniques and Applications
- Colorectal and Anal Carcinomas
- CAR-T cell therapy research
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
University of Michigan
2019-2025
Ann Arbor Center for Independent Living
2024
VA Ann Arbor Healthcare System
2023
The University of Texas Southwestern Medical Center
2004-2022
Southwestern Medical Center
2018-2022
Stanford University
2013-2022
Creative Commons
2022
Palo Alto University
2022
Michigan Medicine
2020
Stanford Cancer Institute
2015-2019
Purpose Multiple smaller studies have demonstrated an association between overall survival and lymph node (LN) count from neck dissection in patients with head cancer. This is a large cohort study to examine these associations by using national cancer database. Patients Methods The National Cancer Database was used identify who underwent upfront nodal for mucosal squamous cell carcinoma 2004 2013. were stratified LN into those < 18 nodes ≥ on the basis of prior work. A multivariable Cox...
Lymph node metastasis (LNM) is a significant prognostic factor in patients with head and neck cancer, the ability to predict it accurately essential for treatment optimization. PET CT imaging are routinely used LNM identification. However, uncertainties of always exist especially small size or reactive nodes. Radiomics deep learning two preferred imaging-based strategies malignancy prediction. models built based on handcrafted features, can learn features automatically. We proposed hybrid...
Abstract Purpose: In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC), (i) to investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA) and association with progression after chemoradiation, (ii) compare the predictive value ctDNA imaging biomarkers MRI FDG-PET. Experimental Design: Serial blood samples were collected from patients AJCC8 stage III OPSCC (n = 34) enrolled on a randomized trial: pretreatment; during chemoradiation at weeks 2, 4, 7;...
Development of evidence-based post-treatment surveillance guidelines in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is limited by comprehensive documentation patterns recurrence metastatic spread.A retrospective analysis patients diagnosed with R/M HNSCC at a National Cancer Institute-designated cancer center between 1998- 2019 was performed (n = 447). Univariate multivariate identified predictors survival.Median overall survival (mOS) improved over time (6.7...
Lymph node metastasis (LNM) is a significant prognostic factor in patients with head and neck cancer, the ability to predict it accurately essential for treatment optimization. PET CT imaging are routinely used LNM identification. However, uncertainties of always exist especially small size or reactive nodes. Radiomics deep learning two preferred imaging-based strategies malignancy prediction. models built based on handcrafted features, can learn features automatically. We proposed hybrid...
Abstract Purpose: We conducted a randomized phase II multicenter clinical trial to test the hypothesis that physiologic MRI-based radiotherapy (RT) dose escalation would improve outcome of patients with poor prognosis head and neck cancer. Patients Methods: MRI was acquired at baseline RT fraction 10 create low blood volume/apparent diffusion coefficient maps for boost subvolume definition in gross tumor volume. were receive 70 Gy (standard RT) or 80 (RT boost) concurrent weekly platinum....
PURPOSE To use a hybrid method, combining statistical profiling, machine learning (ML), and clinical evaluation to predict emergency department (ED) visits among patients with head neck cancer undergoing radiotherapy. MATERIALS AND METHODS Patients treated radiation therapy from 2015 2019 were identified using electronic health record data. Records 60 days before 90 after treatment analyzed. Statistical profiling ML used create predictive model for ED during or therapy. A comprehensive set...
Objectives To evaluate the significance of increasing depth invasion (DOI) as sole risk factor for recurrence in patients with low‐risk early‐stage oral cavity squamous cell carcinoma (OCSCC). Methods We retrospectively reviewed 560 OCSCC treated at our institution between 2003 and 2013. Patients were included if they had surgical resection ± neck dissection no adjuvant therapy. Low was defined absence positive or close margins, lymphovascular invasion, perineural lymph nodes. tumor (T)3‐T4...
Given the established associations between performance status and survival in a variety of cancers, there is significant interest using biometric wearable device (WD) to predict outcomes oncology population. In this pilot study, we investigated ability WD meaningful clinical end points patients undergoing head neck radiotherapy.Patients receiving definitive chemoradiotherapy or postoperative radiotherapy/chemoradiotherapy were enrolled designed show 90% compliance with device. Individuals...
Financial hardship is a growing concern for patients with cancer. Patients head and neck cancer (HNC) are particularly vulnerable, given that third leave the workforce following treatment. The goal of our study was to characterize financial in psychologic response (response increased expenses) coping behaviors (behaviors adopt manage their care setting domains HNC compared other cancers.This retrospective cohort nationally representative public survey data from 2013 2018 National Health...
Optimal surveillance paradigms for survivors of early stage human papillomavirus (HPV)-related oropharyngeal cancer are not well defined. This study aimed to characterize patient interest in and factors associated with an altered paradigm.We surveyed patients Stage I or II HPV-related treated at a tertiary care institution from 2016 2019. Primary outcomes were descriptive assessment knowledge, surveillance, burdens in-person appointments, priorities visits. Ordinal regression was used...
Abstract Background We sought to characterize early changes in CD8 + tumor‐infiltrating lymphocytes and tumor transcriptomes after induction cetuximab a cohort with p16‐positive oropharyngeal cancer on phase II clinical de‐escalation trial. Methods Tumor biopsies were obtained before 1 week single loading dose eight patients enrolled trial of radiotherapy. Changes assessed. Results One cetuximab, five (62.5%) had an increase cell infiltration median (range) fold change +5.8 (2.5–15.8). Three...