A5012235248- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Endometrial and Cervical Cancer Treatments
- T-cell and Retrovirus Studies
- Ovarian cancer diagnosis and treatment
- RNA Interference and Gene Delivery
- Maternal and fetal healthcare
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- HIV Research and Treatment
- Reproductive Health and Contraception
- Assisted Reproductive Technology and Twin Pregnancy
- Ureteral procedures and complications
- Cervical Cancer and HPV Research
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Statistical Methods in Clinical Trials
- Pregnancy and preeclampsia studies
- Animal Disease Management and Epidemiology
- Pediatric health and respiratory diseases
University of Michigan
2019-2025
Rutgers, The State University of New Jersey
2023
Rutgers Cancer Institute of New Jersey
2023
The University of Texas Medical Branch at Galveston
2022
Inova Health System
2015
George Mason University
2012-2015
Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent of adult leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The infects between 15 20 million people worldwide which approximately 2-5% develop ATL. past 35 years research have yielded significant insight into pathogenesis HTLV-1, including molecular characterization Tax, viral transactivator, oncoprotein. In spite these efforts, mechanisms oncogenesis this...
<h3>Importance</h3> In men with recurrent prostate cancer, addition of long-term antiandrogen therapy to salvage radiotherapy (SRT) was associated overall survival (OS) in the NRG/RTOG 9601 study. However, hormone has morbidity, and there are no validated predictive biomarkers identify which patients derive most benefit from treatment. <h3>Objective</h3> To examine role pre-SRT prostate-specific antigen (PSA) levels personalize use SRT. <h3>Interventions</h3> Men were randomized SRT plus...
HIV-1 infection results in a chronic but incurable illness since long-term HAART can keep the virus to an undetectable level. However, discontinuation of therapy rapidly increases viral burden. Moreover, patients under frequently develop various metabolic disorders and HIV-associated neuronal disease. Today, main challenge research is elimination residual infected individuals. The current diagnostics are largely comprised serological nucleic acid based technologies. Our goal integrate...
BACKGROUND: The Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) working group identified metastasis-free survival as a valid surrogate end point for overall (OS) patients with localized prostate cancer. No comparably validated points exist advanced METHODS: We searched trials cancer, defined node-positive, metastatic castration-sensitive, nonmetastatic, or castration-resistant Eligible randomized reported OS and one more intermediate clinical points, including biochemical...
A majority of high-grade (HG) serous ovarian cancer (SOC) patients develop resistant disease despite high initial response rates to platinum/paclitaxel-based chemotherapy. We identified shed/secreted proteins in preclinical models paclitaxel-resistant human HGSOC and correlated these candidate with patient outcomes using public data from patients. Proteomic analyses a cell line secretome was compared those syngeneic variant established an intrinsically chemorefractory patient. Associations...
The implementation of new antiretroviral therapies targeting transcription early viral proteins in postintegrated HIV-1 can aid overcoming current therapy limitations. Using high-throughput screening assays, we have previously described a novel Tat-dependent transcriptional inhibitor named 6-bromoindirubin-3'-oxime (6BIO). 6BIO derivatives yielded unique compounds that show potent inhibition transcription. We identified second-generation derivative called 18BIOder as an TZM-bl cells and...
The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs, suggests that cellular RNAi machinery is a major means by which host mounts defense response against present day retroviruses. Indeed, miRNAs target and hybridize specific both HTLV-1 HIV-1 viral transcripts. However, much like variety immune responses retroviral infection, virus itself contains mechanisms assist in evasion inhibition control pathway. Retroviruses can hijack...
Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia. The HTLV-1 transactivator protein Tax has been identified as a critical component in proliferation and transformation human primary T-cells. This 40 kDa phosphoprotein not only manipulates chromatin remodeling within host, but also subverts host cell DNA damage response mechanisms, cycle progression, apoptosis. Here we utilized combination filtration ultracentrifugation methods to enrich for exosomes...
Optimal surveillance paradigms for survivors of early stage human papillomavirus (HPV)-related oropharyngeal cancer are not well defined. This study aimed to characterize patient interest in and factors associated with an altered paradigm.We surveyed patients Stage I or II HPV-related treated at a tertiary care institution from 2016 2019. Primary outcomes were descriptive assessment knowledge, surveillance, burdens in-person appointments, priorities visits. Ordinal regression was used...
Gene silencing via non-coding RNA, such as siRNA and miRNA, can occur at the transcriptional, post-transcriptional, translational stages of expression. Transcriptional gene (TGS) involving RNAi machinery generally occurs through DNA methylation, well histone post-translational modifications, corresponding remodeling chromatin around target into a heterochromatic state. The mechanism by which mammalian TGS includes recruitment RNA-induced initiation transcriptional (RITS) complexes,...
Objective: To report the impact of race on clinical outcomes in patients with stage IIIC endometrial carcinoma. Materials and Methods: A retrospective multi-institutional study included 90 black 568 non-black carcinoma who received adjuvant chemotherapy radiation treatments. Overall survival (OS) recurrence-free (RFS) were calculated by Kaplan-Meier method. Propensity score matching (PSM) was conducted. Statistical analyses conducted using SPSS version 27. Results: The Median follow-up 45.3...
IntroductionMucosal melanomas represent 1.3% of all melanomas. Of those, 18% arise within the female genital tract (FGT).1Chang AE Karnell LH Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: A summary 84,836 cases from past decade. American College Surgeons Commission Society.Cancer. 1998; 83: 1664-1678Google Scholar,2Patrick RJ Fenske NA Messina JL. Primary mucosal melanoma.J Am Acad Dermatol. 2007; 56: 828-834Google Scholar Unique molecular profiles...
The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs suggests that cellular RNAi machinery is a major means by which host mounts defense response against retroviruses. Indeed, miRNAs target and hybridize specific both HTLV-1 HIV-1 viral transcripts. However, virus itself contains various mechanisms assist in evasion inhibition control pathway. Retroviruses can hijack components pathway, some cases produce novel either active...
Purpose To investigate p16 effects on diffusion image metrics and associations with tumor progression in patients locally advanced head neck cancers. Methods Diffusion images pretreatment after 20 Gy (2wk) of RT were analyzed cT4/N3 p16+ oropharynx cancer (OPSCC) (N=51) locoregionally squamous cell carcinoma (LAHNSCC) (N=28), enrolled onto a prospective adaptive trial. Mean ADC values, subvolumes &lt;1.2 um 2 /ms (TV LADC ), peak values low (µ L ) high H components histograms primary...