A5027762171- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Orthopaedic implants and arthroplasty
- Medical Imaging and Analysis
- Bone health and osteoporosis research
- Esophageal and GI Pathology
- Orthopedic Infections and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Voice and Speech Disorders
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Management of metastatic bone disease
- Cancer survivorship and care
- Bone and Joint Diseases
- Salivary Gland Disorders and Functions
- Temporomandibular Joint Disorders
- Digital Radiography and Breast Imaging
- Medical Imaging Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
University of Michigan
2010-2021
Michigan Medicine
2020
VA Ann Arbor Healthcare System
2019
University of Illinois Chicago
2008
University of Chicago
2003-2008
University of Chicago Medical Center
2008
We have evaluated the performance of an automated classifier applied to task differentiating malignant and benign lung nodules in low-dose helical computed tomography (CT) scans acquired as part a cancer screening program. The classified this manner were initially identified by our nodule detection method, so that output was used input classification. This study begins narrow distinction between "detection task" "classification task." Automated is based on two- three-dimensional analyses CT...
Total body irradiation (TBI) is used as a preconditioning regimen prior to bone marrow transplant for treatment of hematologic malignancies. During TBI, large volumes normal tissue are irradiated, and this can lead toxicities, most significantly in the lungs. Intensity modulated total (IMTMI) may be able reduce these toxicities by directly targeting while minimizing dose critical structures. The goal study was assess feasibility IMTMI following planning delivery process Rando phantom. A...
Osteoporosis is a disease that results in an increased risk of bone fracture due to loss mass and deterioration structure. Bone mineral density (BMD) provides measure frequently measured by densitometry systems diagnose osteoporosis. In addition, computerized radiographic texture analysis (RTA) currently being investigated as structure additional diagnostic predictor this study, we assessed the ability peripheral (PD) system yield images useful for RTA. The benefit such it measures BMD...
Periprosthetic osteolysis is one of the most serious long‐term problems in total hip arthroplasty. It has been primarily attributed to body's inflammatory response submicron polyethylene particles worn from implant, and it leads bone loss structural deterioration surrounding bone. was previously demonstrated that radiographic texture analysis (RTA) ability distinguish between normal cases at time clinical detection disease; however, did not take into account changes over time. The goal this...
Osteoporosis is a disease characterized by loss of bone mass and deterioration structure. Bone mineral density (BMD) measures currently the method used to diagnose osteoporosis, while computerized radiographic texture analysis (RTA) being investigated as measure The GE/Lunar PIXI peripheral densitometer (PD) system, which uses dual-energy subtraction BMD, also provides digital image heel or forearm. goal our current research was evaluate physical imaging properties system (pixel size 0.2 mm)...
We combined clinical practice changes, standardizations, and technology to automate aggregation, integration, harmonization of comprehensive patient data from the multiple source systems used in into a big analytics resource system (BDARS). then developed novel artificial intelligence algorithms, coupled with BDARS, identify structure dose volume histograms (DVH) metrics associated dysphagia.From BDARS harmonized ≥22,000 patients, we identified 132 patients recently treated for head neck...
Purpose: Plan degradation resulting from compromises made to enhance delivery efficiency is an important consideration for intensity modulated radiation therapy (IMRT) treatment plans. IMRT optimization and/or multileaf collimator (MLC) sequencing schemes can be modified generate more efficient delivery, but the effect those modifications have on plan quality often difficult quantify. In this work, authors present a method quantitative assessment of overall due tradeoffs between and quality,...
Periprosthetic osteolysis is a disease triggered by the body's response to tiny wear fragments from total hip replacements (THR), which leads localized bone loss and disappearance of trabecular texture. We have been investigating methods temporal radiographic texture analysis (tRTA) help detect periprosthetic osteolysis. One method involves merging feature measurements at multiple time points using an LDA or BANN. The major drawback this that several cases do not meet inclusion criteria...
Stereotactic body radiation therapy (SBRT) use has increased among patients without pathologic confirmation (PC) of lung cancer. Empirical SBRT PC raises concerns about variation in workup and patient selection, but national trends have not been well described. In this study, we assessed patterns empirical use, workup, causes death a large non-small cell cancer (NSCLC) cohort.We identified 2221 treated with for cT1-T2aN0M0 NSCLC the Veterans Affairs health care system from 2008 to 2015. We...
Periprosthetic osteolysis is a disease caused by the body's response to submicron polyethylene debris particles from hip implant in total replacement (THR) patients. It leads resorption of bone surrounding and deterioration bone's trabecular texture, but this difficult detect until later stages progression. Radiographic texture analysis methods have shown promise detecting at an earlier stage; however, changes over time may be more important than absolute measures. In research, we...
We have been developing radiographic texture analysis (RTA) for assessing osteoporosis and the related risk of fracture. Currently, analyses are performed on heel images obtained from a digital imaging device, GE/Lunar PIXI, that yields both bone mineral density (BMD) (0.2-mm pixels; 12-bit quantization). RTA is image data in region-of-interest (ROI) placed just below talus order to include trabecular structure analysis. found variations occur manually selecting this ROI RTA. To reduce...