A5070289110- MRI in cancer diagnosis
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Radiotherapy Techniques
- Ultrasound and Hyperthermia Applications
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Dysphagia Assessment and Management
- Bone and Joint Diseases
- Prostate Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Esophageal Cancer Research and Treatment
- Effects of Radiation Exposure
- RNA Interference and Gene Delivery
University of Michigan
2016-2025
Henry Ford Hospital
2013-2018
Ford Motor Company (United States)
2015
Neurology, Inc
2015
Zero to Three
2014
Oakland University
2013
Michigan United
2013
University of Rochester
2013
Purpose To determine the in vitro accuracy, test‐retest repeatability, and interplatform reproducibility of T 1 quantification protocols used for dynamic contrast‐enhanced MRI at 1.5 3 T. Methods A phantom with 14 samples was imaged eight centers a common inversion‐recovery spin‐echo (IR‐SE) protocol variable flip angle (VFA) using seven angles, as well site‐specific (VFA different repetition time, proton density, Look‐Locker inversion recovery). Factors influencing accuracy (deviation from...
Abstract Purpose: In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC), (i) to investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA) and association with progression after chemoradiation, (ii) compare the predictive value ctDNA imaging biomarkers MRI FDG-PET. Experimental Design: Serial blood samples were collected from patients AJCC8 stage III OPSCC (n = 34) enrolled on a randomized trial: pretreatment; during chemoradiation at weeks 2, 4, 7;...
This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure individual AIF each set and submitted results managing center. These AIFs, their reference tissue-adjusted variants,...
Pharmacokinetic analysis of dynamic contrast-enhanced (DCE) MRI data allows estimation quantitative imaging biomarkers such as Ktrans (rate constant for plasma/interstitium contrast reagent (CR) transfer) and ve (extravascular extracellular volume fraction). However, the use DCE-MRI in clinical practice is limited with uncertainty arterial input function (AIF) determination being one primary reasons. In this multicenter study to assess effects AIF variations on pharmacokinetic parameter...
Purpose To test the hypothesis that a noninvasive dynamic contrast enhanced MRI (DCE‐MRI) derived interstitial volume fraction ( v e ) and/or distribution V D were correlated with tumor cellularity in cerebral tumor. Methods T 1 ‐weighted DCE‐MRI studies performed 18 athymic rats implanted U251 xenografts. After DCE‐MRI, sectioned brain tissues stained Hematoxylin and Eosin for cell counting. Using Standard Model analysis Logan graphical plot, image sets during after injection of gadolinium...
<h3>BACKGROUND AND PURPOSE:</h3> Standard assessment criteria for brain tumors that only include anatomic imaging continue to be insufficient. While numerous studies have demonstrated the value of DSC-MR perfusion metrics this purpose, they not been incorporated due a lack confidence in consistency across sites and platforms. This study addresses limitation with comparison multisite/multiplatform analyses shared datasets patients tumors. <h3>MATERIALS METHODS:</h3> data were collected after...
The purpose of this study was to characterize changes in tumor vascular parameters hours after a single radiation exposure an orthotopic brain model. U-251 human tumors were established intracerebrally rat brains, and blood flow, forward volume transfer constant (Ktrans) interstitial fraction (ve) measured using magnetic resonance imaging (MRI). Tumors stereotactic treatment 20 Gy. Vascular assessed one additional time between 2 24 h irradiation. After the second MRI session, tissue...
Abstract Purpose: We conducted a randomized phase II multicenter clinical trial to test the hypothesis that physiologic MRI-based radiotherapy (RT) dose escalation would improve outcome of patients with poor prognosis head and neck cancer. Patients Methods: MRI was acquired at baseline RT fraction 10 create low blood volume/apparent diffusion coefficient maps for boost subvolume definition in gross tumor volume. were receive 70 Gy (standard RT) or 80 (RT boost) concurrent weekly platinum....
Functional liver parenchyma can be damaged from treatment of malignancies with
MRI estimates of extracellular volume and tumor exudate flux in peritumoral tissue are demonstrated an experimental model cerebral tumor. Peritumoral predicted the flux. Eighteen RNU athymic rats were inoculated intracerebrally with U251MG cells studied dynamic contrast enhanced (DCE‐MRI) approximately 18 days post implantation. Using a selection paradigm novel application Patlak Logan plots to DCE‐MRI data, distribution (i.e. porosity) leaky rim that external (the outer rim) estimated, as...
Quantitative mapping of hyperperfused and hypercellular regions glioblastoma has been proposed to improve definition tumor at risk for local recurrence following conventional radiation therapy. As the processing multiparametric dynamic contrast-enhanced (DCE-) diffusion-weighted (DW-) magnetic resonance imaging (MRI) data delineation these subvolumes requires additional steps that go beyond standard practices target definition, we sought devise a workflow support timely planning treatment...
Purpose: FDG-PET adds to clinical factors, such tumor stage and p16 status, in predicting local (LF), regional (RF), distant failure (DF) poor prognosis locally advanced head neck cancer (HNC) treated with chemoradiation. We hypothesized that MRI-based quantitative imaging (QI) metrics could add predictors of treatment more significantly than metrics. Materials methods: Fifty four patients HNCs who were enrolled an IRB approved prospective adaptive chemoradiotherapy trial analyzed....
Abstract Background Adversely prognostic hypercellular and hyperperfused regions of glioblastoma (GBM) predict progression-free survival, are a novel target for dose-intensified chemoradiation (chemoRT) recently implemented in phase II clinical trial. As secondary aim, we hypothesized that chemoRT would induce greater mid-treatment response hypercellular/hyperperfused tumor vs standard chemoradiation, early improve overall survival (OS). Methods Forty-nine patients with newly diagnosed GBM...
The distribution of dynamic contrast‐enhanced MRI (DCE‐MRI) parametric estimates in a rat U251 glioma model was analyzed. Using Magnevist as contrast agent (CA), 17 nude rats implanted with cerebral were studied by DCE‐MRI twice 24 h interval. A data‐driven analysis selected one three models to estimate either (1) plasma volume ( v p ), (2) and forward transfer constant K trans ) or (3) , interstitial fraction e constituting Models 1, 2 3, respectively. CA V D estimated Model 3 regions Logan...
The measurement of extracellular pH (pH e ) has significant clinical value for pathological diagnoses and monitoring the effects pH‐altering therapies. One major problems measuring with a relaxation‐based MRI contrast agent is that longitudinal relaxivity depends on both concentration agent, requiring use second pH‐unresponsive to measure concentration. Here we tested feasibility dendritic in concentration‐independent manner at clinically relevant field strengths. transverse relaxation times...