A5100599303- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Statistical Methods in Clinical Trials
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Analytical Chemistry and Chromatography
- Statistical Methods and Inference
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Cold Atom Physics and Bose-Einstein Condensates
- Meningioma and schwannoma management
- Advanced Causal Inference Techniques
- Temporomandibular Joint Disorders
- Quantum, superfluid, helium dynamics
- Ureteral procedures and complications
- Economic and Financial Impacts of Cancer
- Laser Applications in Dentistry and Medicine
- Meta-analysis and systematic reviews
Chinese PLA General Hospital
2024-2025
Qinghai University
2024
Henry Ford Hospital
2020-2023
Henry Ford Health System
2021-2023
Henan Agricultural University
2023
Beijing University of Chinese Medicine
2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2022
University of Michigan
2017-2022
National Medical Products Administration
2022
Trinity Health Oakland Hospital
2022
Cancer treatment delay has been reported to variably impact cancer-specific survival and coronavirus disease 2019 (COVID-19)-specific mortality during the severe acute respiratory syndrome 2 pandemic. During pandemic, is being recommended in a nonquantitative, nonobjective, nonpersonalized manner, this approach may be associated with suboptimal outcomes. Quantitative integration of cancer estimates data on consequences needed aid decisions improve patient outcomes.To obtain quantitative...
Patients with COVID-19 infection are commonly reported to have an increased risk of venous thrombosis. The choice anti-thrombotic agents and doses currently being studied in randomized controlled trials retrospective studies. There exists a need for individualized stratification thromboembolism (VTE) assist clinicians decision-making on anticoagulation. We sought identify the factors VTE patients, which could help physicians prevention, early identification, management hospitalized patients...
Purpose: FDG-PET adds to clinical factors, such tumor stage and p16 status, in predicting local (LF), regional (RF), distant failure (DF) poor prognosis locally advanced head neck cancer (HNC) treated with chemoradiation. We hypothesized that MRI-based quantitative imaging (QI) metrics could add predictors of treatment more significantly than metrics. Materials methods: Fifty four patients HNCs who were enrolled an IRB approved prospective adaptive chemoradiotherapy trial analyzed....
Abstract Background Adversely prognostic hypercellular and hyperperfused regions of glioblastoma (GBM) predict progression-free survival, are a novel target for dose-intensified chemoradiation (chemoRT) recently implemented in phase II clinical trial. As secondary aim, we hypothesized that chemoRT would induce greater mid-treatment response hypercellular/hyperperfused tumor vs standard chemoradiation, early improve overall survival (OS). Methods Forty-nine patients with newly diagnosed GBM...
The intake of dietary antioxidants and glycolipid metabolism are closely related to chronic kidney disease (CKD), particularly among individuals with abdominal obesity. Nevertheless, the cumulative effect multiple comorbid risk factors on progression complications CKD remains inadequately characterized. This study analyzed data from National Health Nutrition Examination Survey (NHANES) dat abase (2005–2018), examine potential CKD, including metabolism, antioxidant intake, pertinent medical...
Conventional dose finding designs in oncology drug development target on the identification of maximum tolerated (MTD), with assumption that MTD has most potential clinical activity among those identified tolerable levels. However, immuno-oncology (I-O) and cell therapy area, may lack dose-efficacy monotonicity, posing significant challenges statistical for trials. A desirable design should empower trial to identify right level toxicity acceptable efficacy. Such is called as optimal...
Optimal surveillance paradigms for survivors of early stage human papillomavirus (HPV)-related oropharyngeal cancer are not well defined. This study aimed to characterize patient interest in and factors associated with an altered paradigm.We surveyed patients Stage I or II HPV-related treated at a tertiary care institution from 2016 2019. Primary outcomes were descriptive assessment knowledge, surveillance, burdens in-person appointments, priorities visits. Ordinal regression was used...
Migraine is a major cause of disability worldwide, particularly in young adults and middle-aged women. Xiongshao Zhitong Recipe (XZR) traditional Chinese medicine prescription used for treating migraine, but its bioactive components therapeutic mechanisms remain unclear. We aimed to confirm the effect XZR on migraine determine possible mechanism XZR. Here, sensitive UHPLC-LTQ-Orbitrap MS assay was carried out analyze ingredients XZR, total 62 were identified, including coumarins, phenolic...
It is clear that alcohol consumption a major risk factor in the pathogenesis of head and neck squamous cell carcinoma (HNSCC); however, molecular mechanism underlying alcohol-associated HNSCC remains poorly understood. The aim present study was to identify characterize P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) PIWI proteins dysregulated elucidate their function development this cancer. Using next generation RNA-sequencing (RNA-seq) data obtained from 40 patients, piRNA...
To evaluate whether response assessment of newly diagnosed glioblastoma at 3 months using 11C-methionine-positron emission tomography (MET-PET) is better associated with patient outcome compared baseline MET-PET or anatomic magnetic resonance imaging alone.Patients included were participants in a phase I/II trial dose-escalated chemoradiation based on imaging. Automated segmentation metabolic tumor volume (MTV) was performed threshold 1.5 times mean cerebellar uptake. Progression-free (PFS)...
To evaluate functional outcomes of robot-assisted ureteroplasty with labial mucosa grafting for long proximal ureteral stenosis (LPUS) in children and adolescents.
African American individuals are disproportionately affected by lung cancer in terms of incidence and mortality. In oncogene-driven non-small-cell (NSCLC), emerging evidence indicates that underlying molecular heterogeneity, which can be ancestry, contributes to variable drug sensitivity therapeutic responses. The purpose this study was evaluate race-associated differences reported treatment decisions, outcomes, features KRAS- EGFR-mutant NSCLC.This is a retrospective using real-world...
Carbon nanomaterials are widely produced and used in industry, medicine scientific research. To examine the impact of exposure to nanoparticles on human health, airway epithelial cell line, Calu-3, was evaluate changes cellular proteome that could account for alterations function epithelia after 24 hexposure 10 μg/mL 100 ng/mL two common carbon nanoparticles, single- multi-wall nanotubes (SWCNT, MWCNT). After label-free quantitative mass spectrometry (LFQMS) study differential protein...
Previous studies have shown that children of alcohol use disorder (AUD) parents are more likely to develop problems as well antisocial and other behavior problems. The purpose this study was examine gender discordance in the effect early maternal paternal influences on behaviors boys girls, environmental factors moderate parental effects. Specifically, we examined effects childhood adulthood offspring young adults. We also whether mothers’ fathers’ drinking when were (6–8 years) affected...
Abstract In many settings, including oncology, increasing the dose of treatment results in both increased efficacy and toxicity. With availability validated biomarkers prediction models, there is potential for individualized dosing based on patient specific factors. We consider setting where an existing dataset patients treated with heterogenous doses binary toxicity outcomes factors such as clinical features biomarkers. The goal to analyze data estimate optimal each (future) their propose...
Abstract Background Alternative therapeutic strategies are needed for localized oropharyngeal carcinoma. Cetuximab represents a potential option those ineligible cisplatin or, until recently, an agent de‐escalation in low risk HPV+ carcinoma (OPSCC). Our objective was to define the toxicity and efficacy of cetuximab‐radiotherapy. Methods We conducted paired phase II trials evaluating cetuximab‐radiotherapy two cohorts (a) OPSCC (b) ineligible. The mean follow‐up 48 months. Results Forty‐two...