A5019383272- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
University of California, San Diego
2014-2019
Head and neck squamous cell carcinoma persists as one of the most common deadly malignancies, with early detection effective treatment still posing formidable challenges. To expand our currently sparse knowledge noncoding alterations involved in disease identify potential biomarkers therapeutic targets, we globally profiled dysregulation small nucleolar long RNAs head tumors. Using next-generation RNA-sequencing data from 40 pairs tumor matched normal tissues, found 2808 RNA (lncRNA)...
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease marked by frequent recurrence metastasis stagnant survival rates. To enhance molecular knowledge of HNSCC define a non-coding RNA (ncRNA) landscape the disease, we profiled transcriptome-wide dysregulation long (lncRNA), microRNA (miRNA), PIWI-interacting (piRNA) using RNA-sequencing data from 422 patients in The Cancer Genome Atlas (TCGA). 307 transcripts differentially expressed were significantly correlated with...
It is clear that alcohol consumption a major risk factor in the pathogenesis of head and neck squamous cell carcinoma (HNSCC); however, molecular mechanism underlying alcohol-associated HNSCC remains poorly understood. The aim present study was to identify characterize P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) PIWI proteins dysregulated elucidate their function development this cancer. Using next generation RNA-sequencing (RNA-seq) data obtained from 40 patients, piRNA...
Abstract Though alcohol consumption has been implicated in the pathogenesis of oropharyngeal cancer, molecular mechanism for alcohol-related cancer is poorly understood. In our study, we sought to identify key microRNAs (miRNA), piwi-interacting RNAs (piRNA), and long non-coding (lncRNA) dysregulated by ethanol, as well its known carcinogenic metabolite acetaldehyde, determine role these (ncRNA) play progression cancer. Using next generation sequencing analysis, analyzed RNA head neck...
Abstract Aberrant expression of microRNAs and piwi-interacting RNAs, two distinct classes non-coding RNA (ncRNA) important regulators gene expression, is known to be implicated in human diseases including cancer. The exact roles RNAs the pathogenesis head neck squamous cell carcinoma (HNSCC), however, remain poorly understood. Utilizing next generation sequencing analysis raw data obtained from Cancer Genome Atlas, we discovered significant dysregulation (fold change ≥ 2) 231 60 between...