A5044442450- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Advances in Oncology and Radiotherapy
- Economic and Financial Impacts of Cancer
- Advanced Radiotherapy Techniques
- Virus-based gene therapy research
- Effects of Radiation Exposure
- Endometrial and Cervical Cancer Treatments
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Reconstructive Surgery and Microvascular Techniques
- Ear and Head Tumors
- Health Systems, Economic Evaluations, Quality of Life
- MRI in cancer diagnosis
- Lung Cancer Research Studies
- Cannabis and Cannabinoid Research
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Breast Implant and Reconstruction
- Management of metastatic bone disease
- Ovarian cancer diagnosis and treatment
- Transplantation: Methods and Outcomes
University of Michigan
2005-2025
Brighton Hospital
2019-2024
University of Alabama at Birmingham
2010-2012
University of Alabama
2009-2011
Henry Ford Health System
2007
Abstract Specific viral targeting into intrahepatic tumors remains critical for adenovirus gene therapy in liver cancer. We previously showed that ionizing radiation increases uptake and transgene expression cells colon cancer xenografts. Here, we tested whether induces through virus-cell membrane interaction. found (8 Gy) induced adenoviral transfer rat hepatocytes (WB) human carcinoma (LoVo). This induction (24.4- 6.5-fold, respectively) were significantly diminished by preincubation with...
Abstract Purpose: Liver damage by radiation limits its efficacy in cancer treatment. As can generate apoptotic signals, we wished to examine the potential protect liver inhibiting apoptosis through two key mediators, FAS and tumor necrosis factor receptor 1 (TNFR1). Experimental Design: Radiation-induced was assessed serum aspartate aminotransferase alanine aminotransferase, hepatocyte micronucleus formation, assays (terminal nucleotidyl transferase–mediated nick end labeling caspase-3...
Purpose: FDG-PET adds to clinical factors, such tumor stage and p16 status, in predicting local (LF), regional (RF), distant failure (DF) poor prognosis locally advanced head neck cancer (HNC) treated with chemoradiation. We hypothesized that MRI-based quantitative imaging (QI) metrics could add predictors of treatment more significantly than metrics. Materials methods: Fifty four patients HNCs who were enrolled an IRB approved prospective adaptive chemoradiotherapy trial analyzed....
Abstract Background Evolving epidemiology and improvements in locoregional therapy necessitate reassessment of the relationship between failure distant metastasis squamous cell carcinoma head neck (SCCHN). Methods Retrospective assessments factors associated with metastasis‐free survival were made for 560 patients SCCHN who received definitive radiotherapy (RT) +/− concurrent systemic at our institution 1995 2007. Results Fifty‐six (10.0%) developed metastasis. Three‐year actuarial control...
Locoregionally advanced HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has excellent cure rates, although current treatment regimens are accompanied by acute and long-term toxicities. We designed a phase II deescalation trial for patients with OPSCC to evaluate the feasibility of an upfront neck dissection individualize definitive selection improve quality life without compromising survival.
Abstract Background Single cycle induction chemotherapy (IC) with platinum and 5‐flurouracil (PF) treatment based on clinical response predicts organ preservation in laryngeal cancer. Other agents offer intriguing alternatives potentially increased ease of administration, reduced risk for severe toxicities, sensitivity. Methods We report the results a phase II bioselection trial advanced resectable cancer utilizing an IC regimen two cycles plus docetaxel (TP) Bcl‐2 inhibitor. The primary...
Abstract Background Altered fractionated radiotherapy (RT) has been shown to improve locoregional control (LRC) and overall survival (OS) in squamous cell cancer of the head neck (SCCHN). We investigated patient outcomes using a new parameter: average weekly dose (AWD). Methods The medical records 601 patients who received definitive RT for SCCHN were reviewed. AWD was calculated by dividing total Gray (Gy) treatment time weeks, assessed predictive value. Results Various standard...
Abstract The hypothesis that the human sodium–iodide symporter, NIS, can be used to detect NIS expression using standard radiological techniques was tested adenoviral transduced in tumor xenografts grown mice and a naive dog prostate. Nonradioactive iodide administered systemically animals 1–3 days previously had received local injection of replication‐competent adenovirus expressing under control CMV promoter. distribution radiopacity assessed mouse tumors micro‐CT clinical X‐ray machine...
<div>AbstractPurpose:<p>Locoregionally advanced HPV<sup>+</sup> oropharyngeal squamous cell carcinoma (OPSCC) has excellent cure rates, although current treatment regimens are accompanied by acute and long-term toxicities. We designed a phase II deescalation trial for patients with OPSCC to evaluate the feasibility of an upfront neck dissection individualize definitive selection improve quality life without compromising survival.</p>Patients...
<div>AbstractPurpose:<p>Locoregionally advanced HPV<sup>+</sup> oropharyngeal squamous cell carcinoma (OPSCC) has excellent cure rates, although current treatment regimens are accompanied by acute and long-term toxicities. We designed a phase II deescalation trial for patients with OPSCC to evaluate the feasibility of an upfront neck dissection individualize definitive selection improve quality life without compromising survival.</p>Patients...