A5044994112- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Molecular Biology Techniques and Applications
- Dysphagia Assessment and Management
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Voice and Speech Disorders
- Ultrasound and Hyperthermia Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
University of Michigan
2019-2024
Michigan Medicine
2020
University of Pennsylvania
2015-2019
Hospital of the University of Pennsylvania
2017-2018
California University of Pennsylvania
2018
Rutgers, The State University of New Jersey
2013-2015
Rutgers Cancer Institute of New Jersey
2013-2015
Radiation Oncology Associates
2012
Abstract Purpose: In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC), (i) to investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA) and association with progression after chemoradiation, (ii) compare the predictive value ctDNA imaging biomarkers MRI FDG-PET. Experimental Design: Serial blood samples were collected from patients AJCC8 stage III OPSCC (n = 34) enrolled on a randomized trial: pretreatment; during chemoradiation at weeks 2, 4, 7;...
To investigate whether the inhibition of autophagy by chloroquine (CQ) sensitizes rectal tumors to radiation therapy (RT) or concurrent chemoradiation (chemoRT).In vitro, HCT-116 and HT-29 colorectal cancer (CRC) cell lines were treated as following: (1) PBS; (2) CQ; (3) 5-fluorouracil (5-FU); (4) RT; (5) CQ (6) 5-FU (7) 5-FU; (8) RT. Each group was then exposed various doses (0-8 Gy) depending on experiment. Cell viability proliferative capacity measured...
Abstract Background: Assessing immunotherapy response presents unique challenges, driven by the heterogeneity of clinical responses that are inadequately captured conventional imaging. Early changes in circulating tumor DNA (ctDNA), mutation-based next generation sequencing (NGS), have been shown to serve as a reliable early predictor immune checkpoint inhibitors (ICI). Nevertheless, we may be reaching plateau utility liquid biopsy approaches, which could alleviated non-mutation based whole...
PURPOSE To use a hybrid method, combining statistical profiling, machine learning (ML), and clinical evaluation to predict emergency department (ED) visits among patients with head neck cancer undergoing radiotherapy. MATERIALS AND METHODS Patients treated radiation therapy from 2015 2019 were identified using electronic health record data. Records 60 days before 90 after treatment analyzed. Statistical profiling ML used create predictive model for ED during or therapy. A comprehensive set...
Abstract Purpose: We conducted a randomized phase II multicenter clinical trial to test the hypothesis that physiologic MRI-based radiotherapy (RT) dose escalation would improve outcome of patients with poor prognosis head and neck cancer. Patients Methods: MRI was acquired at baseline RT fraction 10 create low blood volume/apparent diffusion coefficient maps for boost subvolume definition in gross tumor volume. were receive 70 Gy (standard RT) or 80 (RT boost) concurrent weekly platinum....
Optimal surveillance paradigms for survivors of early stage human papillomavirus (HPV)-related oropharyngeal cancer are not well defined. This study aimed to characterize patient interest in and factors associated with an altered paradigm.We surveyed patients Stage I or II HPV-related treated at a tertiary care institution from 2016 2019. Primary outcomes were descriptive assessment knowledge, surveillance, burdens in-person appointments, priorities visits. Ordinal regression was used...
Abstract Background We sought to characterize early changes in CD8 + tumor‐infiltrating lymphocytes and tumor transcriptomes after induction cetuximab a cohort with p16‐positive oropharyngeal cancer on phase II clinical de‐escalation trial. Methods Tumor biopsies were obtained before 1 week single loading dose eight patients enrolled trial of radiotherapy. Changes assessed. Results One cetuximab, five (62.5%) had an increase cell infiltration median (range) fold change +5.8 (2.5–15.8). Three...
Abstract Background For patients with head and neck squamous cell carcinoma (SCC) undergoing surgery followed by postoperative radiotherapy (PORT), time from to completion of adjuvant therapy, “package time” impacts locoregional control (LRC). However, the significance package in HPV+ oropharyngeal SCC (OPSCC) is unknown. Methods We examined TORS resection PORT for OPSCC January 2010 December 2015 ≥18 months follow‐up (n = 267). A cutoff 15 weeks was used delineate into short long groups....
Grade 2 and higher radiation pneumonitis (RP2) is a potentially fatal toxicity that limits efficacy of therapy (RT). We wished to identify combined biomarker signature circulating miRNAs cytokines which, along with radiobiological clinical parameters, may better predict targetable RP2 pathway. In prospective trial response-adapted RT for patients (n = 39) locally advanced non-small cell lung cancer, we analyzed patients' plasma, collected pre- during RT, microRNAs (miRNAs) using array...
To assess patterns of failure and factors affecting recurrence in colorectal cancer patients treated with Y-labeled resin microspheres for metastatic liver disease.We retrospectively reviewed 30 Yttrium-90 radioembolization assessed follow-up computed tomography scans positron emission to determine disease outcomes. All were included survival analysis. Twenty-six hepatic metastases after treatment grouped into 3 patterns: (1) hepatic; (2) extrahepatic; (3) intrahepatic extrahepatic.The...
Dose to normal lung has commonly been linked with radiation-induced toxicity (RILT) risk, but incorporating functional metrics in treatment planning may help further optimize dose delivery and reduce RILT incidence. The purpose of this study was investigate the impact delivered regions by analyzing perfusion (Q), ventilation (V), combined V/Q single-photon-emission computed tomography (SPECT) dose-function regard risk patients non-small cell cancer (NSCLC) who received radiation therapy...
Objective Bioselection to assess tumor response after induction chemotherapy has been introduced as an alternative treatment strategy total laryngectomy for patients with advanced larynx squamous cell carcinoma (LSCC). Tumor‐infiltrating lymphocytes (TILs) have proven serve prognostic biomarkers in head and neck cancer but not evaluated a way select paradigms. The aim of this study is evaluate the role pretreatment TILs LSCC undergoing bioselection paradigm. Study Design Retrospective study....