A5004599737- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- Pharmaceutical Economics and Policy
- Lung Cancer Treatments and Mutations
- Healthcare Policy and Management
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Pharmaceutical industry and healthcare
- Kidney Stones and Urolithiasis Treatments
- Palliative Care and End-of-Life Issues
- Primary Care and Health Outcomes
- Healthcare cost, quality, practices
- Colorectal Cancer Surgical Treatments
- Ureteral procedures and complications
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Medication Adherence and Compliance
- Frailty in Older Adults
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- Sepsis Diagnosis and Treatment
University of Baltimore
2024
Universitätsklinik Marien Hospital Herne
2018-2024
Ruhr University Bochum
2018-2024
Consorci Sanitari Garraf
2023
Memorial Sloan Kettering Cancer Center
2013-2022
Cancer Research And Biostatistics
2020
ETH Zurich
2020
Danish Cancer Society
2020
Arnold Ventures
2018
Kaiser Permanente
2010-2018
The Surveillance, Epidemiology and End Results (SEER)-Medicare-linked database combines clinical information from population-based cancer registries with claims the Medicare program. use of this to study screening, treatment, outcomes, costs has grown in recent years.This paper provides an overview SEER-Medicare files for investigators interested using these data epidemiologic health services research. includes a description linkage SEER included as part SEER-Medicare. also describes types...
If discovered at an early stage, non–small-cell lung cancer is potentially curable by surgical resection. However, two disparities have been noted between black patients and white with this disease. Blacks are less likely to receive treatment than whites, they die sooner whites. We undertook a population-based study estimate the disparity in rates of evaluate extent which associated differences overall survival.
In the United States, black patients generally receive lower-quality health care than white patients. Black may their from a subgroup of physicians whose qualifications or resources are inferior to those who treat
Recent studies of surgery for cancer have demonstrated variations in outcomes among hospitals and surgeons. We sought to examine morbidity after radical prostatectomy prostate cancer.We used the Surveillance, Epidemiology, End Results-Medicare linked data base evaluate health-related prostatectomy. The rates postoperative complications, late urinary complications (strictures or fistulas 31 365 days procedure), long-term incontinence (more than 1 year procedure) were inferred from Medicare...
Background: Despite its benefits in body image, self-esteem, sexuality, and quality of life, historically fewer than 25 percent patients undergo immediate breast reconstruction. After passage the Women Health Cancer Rights Act, studies failed to demonstrate changes reconstructive rates. A recent single-year report suggests significant shifts U.S. reconstruction patterns. The authors' goal was assess long-term trends rates types Methods: serial cross-sectional study performed using Nationwide...
Background. The Surveillance, Epidemiology and End Results (SEER)-Medicare–linked database combines clinical information from population-based cancer registries with claims the Medicare program. use of this to study screening, treatment, outcomes, costs has grown in recent years. Research Design. This paper provides an overview SEER-Medicare files for investigators interested using these data epidemiologic health services research. includes a description linkage SEER included as part...
Among patients who have undergone high-risk operations for cancer, postoperative mortality rates are often lower at hospitals where more of these procedures performed. We undertook a population-based study to estimate the extent which number performed hospital (hospital volume) is associated with survival after resection lung cancer.
Although there is no proven benefit associated with screening for lung cancer, programs are attracting many individuals who perceive themselves to be at high risk due smoking. We sought determine whether the of cancer varies predictably among smokers.We used data on 18 172 subjects enrolled in Carotene and Retinol Efficacy Trial (CARET)-a large, randomized trial prevention-to derive a prediction model. Model inputs included subject's age, sex, asbestos exposure history, smoking history....
ContextCurrent and former smokers are currently being screened for lung cancer with computed tomography (CT), although there limited data on the effect screening has outcomes. Randomized controlled trials assessing CT under way.ObjectiveTo assess whether may increase frequency of diagnosis resection or reduce risk a advanced death from cancer.Design, Setting, ParticipantsLongitudinal analysis 3246 asymptomatic current beginning in 1998 either at 1 2 academic medical centers United States an...
Two assumptions underpin the implementation of pay for performance in Medicare: that with use claims data, patients can be assigned to a physician or practice will have primary responsibility their care, and meaningful fraction care physicians deliver is whom they responsibility.
Background: Randomized trials have established that 5-fluorouracil-based adjuvant chemotherapy following resection of stage III colon cancer reduces subsequent mortality by as much 30%. However, the extent to which therapy is used outside clinical trial setting, particularly among elderly, unknown. Methods: A retrospective cohort study utilizing Surveillance, Epidemiology, and End Results/Medicare-linked database identified 6262 patients aged 65 years older with resected cancer. The primary...
Oral chemotherapy is emerging as a new option for well-selected patients who can manage potentially complex oral regimens and self-monitor potential complications. If choice between parenteral therapy available, may opt because it more convenient to administer, allows them avoid multiple office visits, gives sense of control over their own cancer care. Whether these advantages are maintained in that combine drugs less clear. The use chemotherapeutic agents profoundly affects all aspects...
In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab—brand name Yervoy—at $120,000 for a course therapy. The was associated with an incremental increase in life expectancy four months. Drugs like ipilimumab have fueled perception that launch prices new anticancer drugs and other so-called “specialty” pharmaceutical market been increasing over time increases are unrelated to magnitude expected health benefits. this paper, we discuss unique features assess...
During the past decade, price of cancer drugs and spending for treatments by Medicare have increased dramatically. The author outlines usual tools uses to control its on discusses policies that make a special case prohibit regulation their prices utilization.
Compelling public interest is propelling national efforts to advance the evidence base for cancer treatment and control measures transform way in which aggregated applied. Substantial investments health information technology, comparative effectiveness research, care quality value, personalized medicine support these have resulted considerable progress date. An emerging initiative, one that integrates converging approaches improving care, "rapid-learning care." In this framework, routinely...
Lung cancer screening via annual low-dose computed tomography has poor adoption. We conducted a prospective case-control study among 958 individuals eligible for lung to develop blood-based detection test that when positive is followed by tomography. Changes in genome-wide cell-free DNA fragmentation profiles (fragmentomes) peripheral blood reflected genomic and chromatin characteristics of cancer. applied machine learning fragmentome features identify who were more or less likely have...
Objective To compare surgeon and hospital procedure volume as predictors of outcomes for patients with rectal cancer. Summary Background Data Although a "volume–outcome" relationship exists several major cancer operations, the impact on following surgery remains uncertain, it has not been determined whether or is more important predictor outcomes. Methods A retrospective population-based cohort study utilizing Surveillance, Epidemiology End Results (SEER)-Medicare linked database identified...
Background: A large body of literature documents associations between the volume cases a hospital or surgeon treats and clinical outcomes. Most these studies have used conventional statistical methods that do not recognize fact hospitals surgeons with similar volumes may very different outcomes because systematic differences in processes care, phenomenon exaggerates true significance effect on outcome. Objective: To describe to assess degree this clustering explore impact available...