A5087636613- Acute Myeloid Leukemia Research
- Advanced Biosensing Techniques and Applications
- Polymer Surface Interaction Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nanofabrication and Lithography Techniques
- RNA modifications and cancer
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Contact Dermatitis and Allergies
- Immunotherapy and Immune Responses
- Biosensors and Analytical Detection
- Multiple Myeloma Research and Treatments
- Blood disorders and treatments
- Ferroptosis and cancer prognosis
- Microfluidic and Bio-sensing Technologies
- Cancer Immunotherapy and Biomarkers
- Molecular Junctions and Nanostructures
- Advanced biosensing and bioanalysis techniques
- Drug-Induced Adverse Reactions
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Forensic Entomology and Diptera Studies
- Lymphoma Diagnosis and Treatment
Yale University
2024-2025
Rush University Medical Center
2024
University of Michigan
2018-2023
Duke University
2017-2019
Pratt Institute
2017-2019
Michigan Center for Translational Pathology
2018
The ELISA is the mainstay for sensitive and quantitative detection of protein analytes. Despite its utility, time-consuming, resource-intensive, infrastructure-dependent, limiting availability in resource-limited regions. Here, we describe a self-contained immunoassay platform (the "D4 assay") that converts sandwich into point-of-care test (POCT). D4 assay fabricated by inkjet printing reagents as microarrays on nanoscale polymer brushes glass chips, so all are "on-chip," these chips show...
Poly(ethylene glycol) (PEG), a linear polymer known for its "stealth" properties, is commonly used to passivate the surface of biomedical implants and devices, it conjugated biologic drugs improve their pharmacokinetics. However, antigenicity growing concern. Here, PEG investigated when assembled in poly(oligoethylene methacrylate (POEGMA) "bottlebrush" configuration on planar surface. Using ethylene glycol (EG) repeat lengths POEGMA sidechains as tunable parameter optimization, brushes with...
Core-binding factor acute myeloid leukemia (CBF-AML) is characterized by the presence of inv(16)/t(16;16) or t(8;21) and classified as a favorable risk 2022 European LeukemiaNet (ELN) guidelines. The CD33-targeting antibody-drug conjugate, gemtuzumab ozogamicin (GO), commonly added to intensive chemotherapy (IC) in CBF-AML. We sought compare outcomes patients treated with IC without GO included 200 CBF-AML across seven academic centers. Induction treatment regimens were categorized alone,...
Advances in electronics and life sciences have generated interest "lab-on-a-chip" systems utilizing complementary metal oxide semiconductor (CMOS) circuitry for low-power, portable, cost-effective biosensing platforms. Here, we present a simple reliable approach coating "high-κ" dielectric materials with "non-fouling" (protein- cell-resistant) poly(oligo(ethylene glycol) methyl ether methacrylate (POEGMA) polymer brushes as biointerfacial coatings to improve their relevance applications...
The Michigan Portal for the Analysis of NGS data portal (http://mipanda.org) is an open-access online resource that provides scientific community with access to results a large-scale computational analysis thousands high-throughput RNA sequencing (RNA-seq) samples. gene expression profiles, enabling users interrogate genes across myriad normal and cancer tissues cell lines. From these data, tissue- cancer-specific patterns can be identified. Gene-gene coexpression profiles also interrogated....
Motivated by the lack of adventitious protein adsorption on zwitterionic polymer brushes that promise low noise and hence high analytical sensitivity for surface-based immunoassays, we explored their use as a substrate immunoassay fabrication inkjet printing antibodies. We observed poly(sulfobetaine)methacrylate brush glass is far too hydrophilic to enable noncovalent immobilization antibodies printing. To circumvent this limitation, developed series hybrid zwitterionic–cationic surface...