A5045122246- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Breast Lesions and Carcinomas
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Colorectal and Anal Carcinomas
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Management of metastatic bone disease
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
University of Iowa Hospitals and Clinics
2021-2024
The University of Texas Southwestern Medical Center
2024
Southwestern Medical Center
2024
Stanford University
2011-2022
Stanford Cancer Institute
2015-2022
Cancer Institute (WIA)
2015-2021
Cancer Prevention Institute of California
2020
Stanford Medicine
2010-2019
Digital China Health (China)
2019
Digital Health Cooperative Research Centre
2019
Abstract BACKGROUND: This study was undertaken to determine outcomes of stereotactic body radiotherapy for colorectal liver metastases in a pooled patient cohort. METHODS: Patients with from 3 institutions were included if they had 1 4 lesions, received 6 fractions radiotherapy, and radiologic imaging ≥3 months post‐treatment. Sixty‐five patients 102 lesions treated August 2003 May 2009 retrospectively analyzed. A tumor control probability (TCP) model used estimate the 3‐fraction dose...
Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers available to inform patient outcomes.To evaluate the alterations of 4 main driver genes in and outcomes after cancer resection.This study analyzed protein expression DNA KRAS, CDKN2A, SMAD4, TP53 by immunohistochemistry next-generation sequencing formalin-fixed, paraffin-embedded tumors 356 who were treated Dana-Farber/Brigham Women's Cancer Center (October 26, 2002, May 21,...
Although abundant myeloid cell populations in the pancreatic ductal adenocarcinoma (PDAC) microenvironment have been postulated to suppress antitumor immunity, composition of these populations, their spatial locations, and how they relate patient outcomes are poorly understood.
Abstract Purpose: Neoadjuvant chemotherapy is increasingly administered to patients with resectable or borderline pancreatic ductal adenocarcinoma (PDAC), yet its impact on the tumor immune microenvironment incompletely understood. Experimental Design: We employed quantitative, spatially resolved multiplex immunofluorescence and digital image analysis identify T-cell subpopulations, macrophage polarization states, myeloid cell subpopulations in a multi-institution cohort of up-front resected...
Few studies have simultaneously assessed the prognostic value of multiple classification systems for lymph node (LN) metastases in resected pancreatic ductal adenocarcinoma (PDAC).In 600 patients with PDAC, we examined association LN parameters (AJCC 7th and 8th editions, ratio (LNR), log odds metastatic (LODDS)) pattern recurrence patient survival using logistic regression Cox proportional hazards regression, respectively. Regression models adjusted age, sex, margin status, tumour grade,...
To determine if pretreatment nutritional status and inflammatory markers correlate with survival in patients locally advanced pancreatic adenocarcinoma treated stereotactic body radiotherapy (SBRT).We retrospectively reviewed 208 newly diagnosed, SBRT at our institution from 2002 to 2014. Laboratory values were collected before SBRT, including hemoglobin, platelets, albumin, red blood cell, white neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, tumor CA 19-9 CEA. Patients...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic and deadly cancers. Despite clinical significance spread, our understanding molecular mechanisms that drive PDAC ability remains limited. By generating a genetically engineered mouse model human PDAC, we uncover transient subpopulation cancer cells with exceptionally high ability. Global gene expression profiling functional analyses uncovered transcription factor BLIMP1 as driver metastasis. The highly enriched...
The aim of this study was to investigate the impact statin and metformin therapy on disease outcome for patients with pancreatic ductal adenocarcinoma (PDAC).This retrospective included 171 PDAC who underwent surgical resection at Stanford Cancer Institute between 1998 2013. No received neoadjuvant therapy. Statin use defined as during initial consult continuing upon discharge from hospital after surgery. Dose each medication recorded, type taken.The median follow-up all 11.23 months (range,...
Objectives: The prognostic value of several hematologic parameters, including platelet, lymphocyte, and neutrophil counts, has been studied in a variety solid tumors. In this study, we examined the significance inflammatory markers their implications patients with colorectal cancer (CRC). Materials Methods: Patients stage I-III CRC who underwent surgical resection at Stanford Cancer Institute between 2005 2009 were included. excluded if they did not have preoperative complete blood counts...
Aims To determine whether expression of Smad4, a tumour suppressor found to be absent in 10% colorectal cancer (CRC), is associated with outcomes patients CRC. Methods Tumour samples from 241 consecutive CRC who underwent upfront colon resection between 2005 and 2009 were obtained. Triplicate tissue cores resected primary tumours matched normal controls used construct the microarrays (TMAs). We examined Smad4 using immunohistochemistry. Clinicopathological records obtained for all patients....
Expression of the chromatin-associated protein HMGA2 correlates with progression, metastasis and therapy resistance in pancreatic ductal adenocarcinoma (PDAC). Hmga2 has also been identified as a marker transient subpopulation PDAC cells that increased metastatic ability. Here, we characterize requirement for during growth, dissemination, vivo using conditional inactivation well-established autochthonous mouse models PDAC. Overall survival, primary tumour burden, presence disseminated...
The special AT-rich sequence binding protein (SATB2) has been reported to be a specific immunohistochemical marker for colorectal carcinoma; however, correlation of SATB2 expression with molecular alterations commonly assessed in carcinoma not performed. We examined the 586 adenocarcinomas gastrointestinal (GI) tract and pancreas assess its utility diagnosis analyze clinicopathologic characteristics stratified by expression. CDX2 were evaluated 266 lower GI origin (246 20 appendiceal...
Abstract Using a luciferase reporter–based high-throughput chemical library screen and topological data analysis, we identified N-acridine-9-yl-N',N'-dimethylpropane-1,3-diamine (DAPA) as an inhibitor of the inositol requiring kinase 1α (IRE1α)–X-box binding protein-1 (XBP1) pathway unfolded protein response. We designed collection analogues based on structure DAPA to explore structure–activity relationships N9-(3-(dimethylamino)propyl)-N3,N3,N6,N6-tetramethylacridine-3,6,9-triamine...
To review our institutional experience of treating cholangiocarcinoma using stereotactic body radiation therapy (SBRT).A total 40 patients with intrahepatic (n = 25) or perihilar 15) treated SBRT were retrospectively reviewed. was delivered in 1 to 5 fractions median dose Gy. Competing risk analysis used estimate cumulative incidence local in-field, out-of-field, regional, and distant failure. Kaplan-Meier log-rank tests calculate overall survival (OS). Toxicity scored Common Terminology...
Objectives To evaluate the significance of increasing depth invasion (DOI) as sole risk factor for recurrence in patients with low‐risk early‐stage oral cavity squamous cell carcinoma (OCSCC). Methods We retrospectively reviewed 560 OCSCC treated at our institution between 2003 and 2013. Patients were included if they had surgical resection ± neck dissection no adjuvant therapy. Low was defined absence positive or close margins, lymphovascular invasion, perineural lymph nodes. tumor (T)3‐T4...