A5014879891- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Agricultural Economics and Practices
- Fisheries and Aquaculture Studies
- Innovation and Socioeconomic Development
- Microfinance and Financial Inclusion
- Colorectal Cancer Screening and Detection
- Oral and gingival health research
- Synthesis and biological activity
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Medical Imaging Techniques and Applications
- Signaling Pathways in Disease
- Water Quality Monitoring Technologies
- Topological and Geometric Data Analysis
- Machine Learning in Healthcare
- Trypanosoma species research and implications
- Social and Economic Development in India
- Bone fractures and treatments
- Gender, Education, and Development Issues
- Quinazolinone synthesis and applications
- Gallbladder and Bile Duct Disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer Diagnosis and Treatment
- Forensic Toxicology and Drug Analysis
Cleveland Clinic Florida
2020
Tamil Nadu Veterinary and Animal Sciences University
2020
Beth Israel Deaconess Medical Center
2017-2019
Harvard University
2018
Stanford University
2014-2016
Cancer Institute (WIA)
2016
Stanford Medicine
2016
Central Institute of Brackishwater Aquaculture
2008-2015
Chettinad Health City
2012-2014
Stanford Health Care
2014
This paper applies topological methods to study complex high dimensional data sets by extracting shapes (patterns) and obtaining insights about them. Our method combines the best features of existing standard methodologies such as principal component cluster analyses provide a geometric representation sets. Through this hybrid method, we often find subgroups in that traditional fail find. also permits analysis individual well relationships between related We illustrate use our applying it...
Determine how varying longitudinal historical training data can impact prediction of future clinical decisions. Estimate the "decay rate" source relevance.We trained a order recommender system, analogous to Netflix or Amazon's "Customers who bought A also B..." product recommenders, based on tertiary academic hospital's structured electronic health record data. We used this system predict (2013) admission orders different subsets (2009 through 2012), relative existing human-authored...
To determine if pretreatment nutritional status and inflammatory markers correlate with survival in patients locally advanced pancreatic adenocarcinoma treated stereotactic body radiotherapy (SBRT).We retrospectively reviewed 208 newly diagnosed, SBRT at our institution from 2002 to 2014. Laboratory values were collected before SBRT, including hemoglobin, platelets, albumin, red blood cell, white neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, tumor CA 19-9 CEA. Patients...
Background and study aims Early studies have shown that artificial intelligence (AI) has the potential to augment performance of gastroenterologists during endoscopy. Our aim was determine how view role AI in gastrointestinal Methods In this cross-sectional study, an online survey sent US gastroenterologists. The included questions about physician level training, experience, practice characteristics perception AI. Descriptive statistics were used summarize sentiment Univariate multivariate...
Abstract The benefits of radiotherapy for inoperable biliary tract cancer remain unclear due to the lack randomized data. We evaluated impact on survival in elderly patients using SEER ‐Medicare database. Patients database with tumors diagnosed between 1998 and 2011 were included. used multivariate logistic regression evaluate factors associated treatment selection, Cox propensity score matching selection relation subsequent survival. Of 2343 included, 451 (19%) received within 4 months...
Purpose. To compare 2 methods of fusion in the treatment lumbar spondylolisthesis: posterior interbody (PLIF) and intertransverse (ITF). Methods. 20 patients with spondylolisthesis were randomly allocated to one groups: decompression, instrumentation, PLIF (n=10) or ITF (n=10). The Oswestry low back pain disability questionnaire was used for clinical assessment. Radiography performed preoperatively postoperatively assess reduction slip. Results. In groups, 87.5% 100% had a satisfactory...
Abstract Activation of the IRE1α-XBP1 branch unfolded protein response (UPR) has been implicated in multiple types human cancers, including myeloma (MM). Through an silico drug discovery approach based on protein-compound virtual docking, we identified anthracycline antibiotic doxorubicin as vitro and vivo inhibitor XBP1 activation, a previously unknown activity for this widely utilized cancer chemotherapeutic drug. series mechanistic phenotypic studies, showed that novel was not due to...
Interlocking nailing is a widely accepted and performed treatment for tibial shaft fractures. The addition of percutaneously placed transfixation screws increases the stabilisation provided by intramedullary nailing; however, technical complexity associated with procedure has introduced new potential complications. We report pseudoaneurysm anterior artery caused proximal interlocking screw after surgery to repair fracture. patient experienced complete relief symptoms following removal nail...
Abstract Using a luciferase reporter–based high-throughput chemical library screen and topological data analysis, we identified N-acridine-9-yl-N',N'-dimethylpropane-1,3-diamine (DAPA) as an inhibitor of the inositol requiring kinase 1α (IRE1α)–X-box binding protein-1 (XBP1) pathway unfolded protein response. We designed collection analogues based on structure DAPA to explore structure–activity relationships N9-(3-(dimethylamino)propyl)-N3,N3,N6,N6-tetramethylacridine-3,6,9-triamine...
Abstract Purpose: Public-funded fisheries extension services have been blamed as poor and responsible for the slow pace of aquaculture development in India. The present investigation aimed to find concrete interventions streamline service by understanding research-extension-farmer linkage indirectly terms information sources aqua farmers fishery officers assessing existing organizational, manpower capabilities Departments Fisheries sample states. Design/methodology/approach: A random 1008...
Background: Little is known about the extent of alignment between hematopoietic stem cell transplant (HSCT) patients and their healthcare proxies with respect to advance care planning (ACP). Aim: To determine if a structured three-step process using letter directive (LAD) could (1) allow for differences in opinion patient–proxy dyads surface (2) help bridge preexisting discordance specific treatment choices. Design: Blinded each other, HSCT patient (LAD-1) proxy (LAD-2) completed LAD (step...
317 Background: To report updated outcomes and toxicity of stereotactic body radiotherapy (SBRT) for patients with unresectable pancreatic adenocarcinoma treated over the past 11 years from a single institution. Methods: One hundred ninety-nine primary, were SBRT at our institution 2002 to 2013. sixty-four had locally advanced disease, 12 borderline resectable 21 medically inoperable, 2 disease but refused surgery. Fifteen metastases time SBRT. Forty-six prior RT, 16 whom enrolled on...
Despite advances in reconstructive surgery, salvage of mangled extremities still requires long periods treatment with many operations that can be taxing both to the surgeon and patient. Attempts at reconstruction severely shattered limbs necessitate counselling regard protracted course associated morbidity as well problems which may require abandoning procedure secondary amputation. We report successful a comminuted open fracture tibia 32-year-old man.
Abstract Background and study aims During evaluation of pancreaticobiliary strictures, it is common practice to send biliary stents for cytologic analysis. However, in recent years, complementary tissue acquisition techniques ranging from cholangioscopy fine-needle biopsy have improved the ability acquire diagnose malignancy. Data are limited on current diagnostic yield cost effectiveness stent Patients methods We performed a retrospective all sent analysis tertiary care academic medical...
Shrimp is one of the most traded seafood commodities, and aquaculture shrimp considered to be success stories modern aquaculture. The paper analyses socio-economics selected nursery farms in coastal districts Tamilnadu. data were collected from owners for period 2019 analysed with appropriate tools. study revealed that 42.86 % farmers belonged old age group, 54.29 educated up higher secondary level had farming experience between 5-10 years. economic analysis indicated have realized gross...