A5029137381- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Spine and Intervertebral Disc Pathology
- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- EEG and Brain-Computer Interfaces
- Sarcoma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Optical Imaging and Spectroscopy Techniques
- Spinal Fractures and Fixation Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Fungal Infections and Studies
- Functional Brain Connectivity Studies
- Bone health and treatments
- Nerve injury and regeneration
- Acute Ischemic Stroke Management
Stanford University
2013-2024
Palo Alto University
2022
Stanford Medicine
1997-2021
Neurological Surgery
1997-2021
Stanford Cancer Institute
2021
University of California, Davis
2021
Lucile Packard Children's Hospital
2015
Santa Clara Valley Medical Center
1997
University of Michigan–Ann Arbor
1977
Significance The brain comprises an immense number of cells and cellular connections. We describe the first, to our knowledge, single cell whole transcriptome analysis human adult cortical samples. have established experimental analytical framework with which complexity can be dissected on level. Using this approach, we were able identify all major types characterize subtypes neuronal cells. observed changes in neurons from early developmental late differentiated stages adult. found a subset...
Heavy-charged-particle radiation has several advantages over protons and photons for the treatment of intracranial lesions; it an improved physical distribution dose deep in tissue, a small angle lateral scattering, sharp distal falloff dose.
OBJECTIVE The ability to assess the risk of adverse events based on known patient factors and comorbidities would provide more effective preoperative stratification. Present assessment in spine surgery is limited. An event prediction tool was developed predict complications after tested a prospective cohort. METHODS spinal Risk Assessment Tool (RAT), novel instrument for patients undergoing that an administrative claims database, prospectively applied 246 257 procedures over 3-month period....
Hyperglycemia has been reported to worsen the tolerance of brain ischemia, and it therefore recommended that patients undergoing neurosurgical procedures not receive glucose-containing solutions. However, whereas most animal studies have used global ischemia models, are associated with risks focal rather than ischemia. We studied effects glucose administration in an model cerebral anesthetized 20 cats halothane (0.85% end tidal oxygen), a ischemic lesion was produced by clip ligation left...
In clinical medicine, cerebral ischemia is frequently due to a focal, rather than global, insult. The effect of hyperglycemia in focal not well defined. We studied the on neuropathologic changes rabbit model ischemia. Rabbits were randomized receive saline (n = 12) or glucose infusions. left anterior and internal carotid arteries clipped after infusion began. After 6 hours occlusion, area severe ischemic neuronal damage neocortex striatum two standard sections brain was calculated expressed...
✓ Malignant astroglial neoplasms of the cerebellum are rare and clinical behavior these tumors is unpredictable. The authors describe histological characteristics outcome in 10 patients; eight had malignant cerebellar astrocytomas, one each an astroblastoma a true polar spongioblastoma. glial involving usually behave very aggressively. Cerebellar astroblastomas spongioblastomas too to predict their natural history. Some hypotheses proposed concerning evolution interrelationship cerebellum.
Risk factors for poor outcome in the treatment of very large (≥20-24 mm) and giant (≥25 intracranial aneurysms remain incompletely defined.To present an aggregate clinical series detailing a 24-year experience with to identify assess relative importance various patient, aneurysm, treatment-specific characteristics associated angiographic outcomes.The authors retrospectively identified 184 measuring 20 mm or larger (85 large, 99 giant) treated at Stanford University Medical Center between...
Abstract OBJECTIVE: To compare endovascular versus surface methods for the induction and reversal of hypothermia during neurosurgery in a multicenter, prospective, randomized study. METHODS: Patients undergoing elective open craniotomy repair an unruptured cerebral aneurysm (n = 153) were randomly assigned (2:1) to undergo whole-body 33°C, either with cooling device placed inferior vena cava via femoral vein 92) or convective air blanket 61). Active rewarming was accomplished using same...
Intraoperative ultrasound (US) was compared to computed tomography (CT) in 41 intracranial and 6 spinal cord tumors. The studies correlated closely except for primary gliomas. Eight of the 22 gliomas (37%), including 1 low-grade 7 anaplastic tumors, were larger more extensive on US than CT. Margins non-enhanced astrocytomas shown by but not Four tumors (19%) exhibited echogenicity extending beyond enhanced area. In 4 patients an lesion contained a lucent center which proved be echogenic....
Demonstrating the value of spine care requires adequate outcomes assessment. Long-term are best measured as overall improvement in quality life (QOL) after surgical intervention. Present registries often require parallel data entry, introducing inefficiencies and limiting compliance. The authors detail methodology constructing an integrated electronic health record (EHR) system to collect QOL metrics demonstrate effect collection on routine clinical workflow. A streamlined approach...
We report two cases of central neurocytoma; one located in the right lateral ventricle and associated with a distinctly separate primitive neuroectodermal tumor (PNET)/medulloblastoma fourth ventricle, other admixed fat cells arising from left third ventricles extension into corpus callosum. discuss that concurrent occurrences PNET adipose tissue are not fortuitous events, but an evidence neurocytomas PNETs originate residual germinal pool common progenitor cell rests recapitulating features...
CSF pulsations within nonneoplastic spinal cord cystsDR Enzmann, J O'Donohue, JB Rubin, L Shuer, P Cogen and G SilverbergAudio Available | Share
Abstract Angiographically occult vascular malformations of the optic nerve and chiasm are extremely rare. Before advent magnetic resonance imaging (MRI), it was difficult to diagnose these lesions preoperatively. We report MRI scan findings cavernous angiomas in two patients with chiasmal syndrome. useful localizing malformation delineating its characteristics, especially chronic hemorrhage. One patient underwent biopsy lesion. The other complete microsurgical resection carbon dioxide laser...
Abstract Objective Intracranial electrographic localization of the seizure onset zone (SOZ) can guide surgical approaches for medically refractory epilepsy patients, especially when presurgical workup is discordant or functional cortical mapping required. Minimally invasive stereotactic placement depth electrodes, stereoelectroencephalography (SEEG), has garnered increasing use, but limited data exist to evaluate its postoperative outcomes in context contemporaneous availability both SEEG...
Abstract In the rat, a few long descending motor tracts capable of carrying an impulse and causing propagated in ipsilateral sciatic nerve will regenerate after complete spinal cord transection. this experiment such regeneration was found both treated control animals. Orthograde axonal transport tritiated proline injected into cortex labels only corticospinal rat cord. Scintillation counts measured lengths can be used as measure number labeled axons. Comparison radioactivity per unit length...
The present study was designed to validate our noninvasive ultrasonic technique (pulse phase locked loop: PPLL) for measuring intracranial pressure (ICP) waveforms. is based upon detecting skull movements which are known occur in conjunction with altered pressure. In bench model studies, PPLL output highly correlated changes the distance between a transducer and reflecting target (R2 = 0.977). cadaver transcranial measured while pulsations of ICP (amplitudes zero 10mm Hg) were generated by...
89 patients with angiographically documented arteriovenous malformations were treated helium ion Bragg peak radiation. The rate of complete angiographic obliteration 2 years after radiation was 94% in those lesions smaller than 4 cm3 (2.0 cm diameter), 75% for 4–25 and 39% larger 25 (3.7 diameter); at 3 radiation, the corresponding rates 100, 95 70%. Major clinical complications occurred 10 (8 permanent, transient) between 21 months after. treatment; all initial stage protocol (higher...
Background. Primary neoplasms of the pineal gland are uncommon. Two patients with unusual primary tumors that had similar distinctive histologic features reported. Methods. The surgically resected neoplastic tissue from these were examined by light microscopy, immunohistochemistry, and electron microscopy correlated patients' clinical course. Results. These consisted a mixture spindle-shaped cells fibrillated cell processes many large lipidized and/or granular pleomorphic cells, some which...