A5072935126- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Spine and Intervertebral Disc Pathology
- Moyamoya disease diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Trigeminal Neuralgia and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Spinal Fractures and Fixation Techniques
- Adenosine and Purinergic Signaling
- Musculoskeletal pain and rehabilitation
- Meningioma and schwannoma management
- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Facial Nerve Paralysis Treatment and Research
- EEG and Brain-Computer Interfaces
- Trauma Management and Diagnosis
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Opioid Use Disorder Treatment
Stanford University
2016-2025
Stanford Medicine
2014-2025
Vanderbilt University
2023
Stanford Health Care
2019
Lucile Packard Children's Hospital
2019
University of Calgary
2019
VA Palo Alto Health Care System
2018
<h3>Importance</h3> Deep learning has the potential to augment clinician performance in medical imaging interpretation and reduce time diagnosis through automated segmentation. Few studies date have explored this topic. <h3>Objective</h3> To develop apply a neural network segmentation model (the HeadXNet model) capable of generating precise voxel-by-voxel predictions intracranial aneurysms on head computed tomographic angiography (CTA) clinicians' aneurysm diagnostic performance. <h3>Design,...
Low back pain (LBP) with or without lower extremity (LEP) is one of the most common reasons for seeking medical care. Previous studies investigating costs in this population targeted patients receiving surgery. Little known about health care utilization among who do not undergo surgery.To assess use resources LBP and LEP management analyze associated costs.This cohort study used a retrospective analysis commercial database containing inpatient outpatient data more than 75 million...
<h3>BACKGROUND AND PURPOSE:</h3> Posterior fossa tumors are the most common pediatric brain tumors. MR imaging is key to tumor detection, diagnosis, and therapy guidance. We sought develop an imaging–based deep learning model for posterior detection pathology classification. <h3>MATERIALS METHODS:</h3> The study cohort comprised 617 children (median age, 92 months; 56% males) from 5 institutions with tumors: diffuse midline glioma of pons (<i>n</i> = 122), medulloblastoma 272), pilocytic...
Abstract Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and high recurrence rates. The complex immune microenvironment of GBM infiltrated by tumor-associated microglia macrophages (TAM). TAMs are known to be heterogeneous in their functional metabolic states can transmit either protumoral or antitumoral signals glioma cells. Here, we performed bulk RNA sequencing single-cell on samples from patients GBM, which revealed increased ATP synthase expression oxidative...
BACKGROUND Gangliogliomas are low-grade gliomas typically found in the temporal lobes with a low rate of malignant transformation. In rare cases, they may be spinal axis. OBSERVATIONS An 8-year-old boy presented 2 months neck pain and upper extremity incoordination was to have cervicomedullary lesion. occipital craniectomy C1 laminectomy C2–5 laminoplasty were performed for biopsy partial resection. The pathological diagnosis consistent ganglioglioma, patient followed serial MRI. He 1.5...
OBJECTIVE Geniculate neuralgia (GN) is a rare facial pain syndrome characterized by severe stabbing in the ear canal. The exact cause of GN remains unclear; however, it thought that nervus intermedius (NI) primary implicated structure. When medical management fails, surgical interventions are offered to treat pain. This study aimed present consecutive series patients with who underwent craniotomy NI sectioning, offer insights into safety and efficacy approach. METHODS A retrospective review...
INTRODUCTION: Clinical trials involving immune checkpoint blockade such as anti-PD-1 fail to improve survival compared standard of care in glioblastoma (GBM). Despite the advent new immunotherapies STING agonists and anti-CSF-1R, combination these strategies is limited by necessitation intracranial delivery (STING) or off-target side effects with systemic exposure (anti-CSF-1R + anti-PD-1). We have previously shown that tumor draining lymph nodes via hydrogels decreases results improved...
INTRODUCTION: Despite promising preclinical studies, BRAF/MEK inhibition with vemurafenib in melanoma brain metastases (MBM) has suboptimal durable response humans. Thrombospondin 1 (THBS1), a matricellular protein, is upregulated vemurafenib-resistant metastatic melanoma, and its reverses BRAF inhibitor chemoresistance. However, the characteristics of THBS1-mediated signaling pathways as well methods require further exploration context MBM. METHODS: We analyzed human parenchymal MBM samples...
INTRODUCTION: Despite ongoing efforts to promote greater diversity, equity, and inclusion (DEI) in neurosurgery, significant disparities persist within the neurosurgical community for those who identify as female and/or an underrepresented minority. This is part attributed a lack of early exposure field neurosurgery. METHODS: 102 students were enrolled weekly seminar course that was offered 1 unit undergraduate credit. Course structure involved case studies, Socratic group discussions on...
Imaging evaluation of the cerebral ventricles is important for clinical decision-making in pediatric hydrocephalus. Although quantitative measurements ventricular size, over time, can facilitate objective comparison, automated tools calculating volume are not structured use. The authors aimed to develop a fully deep learning (DL) model ventricle segmentation and calculation widespread implementation across multiple hospitals.
OBJECTIVE Completion corpus callosotomy can offer further remission from disabling seizures when a prior partial has failed and residual callosal tissue is identified on imaging. Traditional microsurgical approaches to section fibers carry risks associated with multiple craniotomies the proximity medially oriented motor cortices. Laser interstitial thermal therapy (LITT) represents minimally invasive approach for ablation of following callosotomy. Here, authors report clinical outcomes 6...
Repressive KRAB domain-containing zinc-finger proteins (KRAB-ZFPs) are abundant in mammalian genomes and contribute both to the silencing of transposable elements (TEs) regulation developmental stage- cell type-specific gene expression. Here we describe studies zinc finger protein 92 (Zfp92), an X-linked KRAB-ZFP that is highly expressed pancreatic islets adult mice, by analyzing global Zfp92 knockout (KO) mice. Physiological, transcriptomic genome-wide chromatin binding indicate principal...
Transnasal endoscopic transsphenoidal approaches constitute an essential technique for the resection of skull base tumors in adults. However, pediatric population, sellar and suprasellar lesions have historically been treated by craniotomy. are less invasive thus may be preferable to craniotomy, especially children. In this case series, authors present their institutional experience with transnasal tumors.
Moyamoya disease is a dynamic cerebrovascular condition that often requires vascular surveillance. Arterial spin labeling (ASL) an MR perfusion method increasingly used for stroke and other various neurovascular pathologies. Unlike perfusion-weighted MRI, ASL uses endogenous water molecules signal therefore obviates gadolinium use; provides direct, not relative, quantitative cerebral blood flow (CBF) measures. Presently, the potential role of evaluating postoperative pediatric moyamoya...