A5021539098- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Phagocytosis and Immune Regulation
- Synthesis of Tetrazole Derivatives
- Synthesis and biological activity
- Ferrocene Chemistry and Applications
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Moyamoya disease diagnosis and treatment
- Neuroblastoma Research and Treatments
- Genomics and Rare Diseases
- Cerebrovascular and genetic disorders
- Protein Degradation and Inhibitors
- Beetle Biology and Toxicology Studies
- Fluid Dynamics and Thin Films
- Photoreceptor and optogenetics research
- CAR-T cell therapy research
- Neurogenesis and neuroplasticity mechanisms
UCSF Benioff Children's Hospital
2018-2024
University of California, San Francisco
2018-2024
UCSF Helen Diller Family Comprehensive Cancer Center
2020
Alexion Pharma (Switzerland)
2013-2020
Stanford University
2002-2018
Stanford Medicine
2018
City College of San Francisco
2018
Institute of Behavioral Sciences
2014
University of California, Irvine
2002-2006
ExxonMobil (United States)
2005
Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially unchanged more than 30 years. characterized by widespread and recurrent somatic copy-number alterations (SCNA) structural rearrangements. In contrast, few point mutations in protein-coding genes have been identified, suggesting that within SCNAs are key oncogenic drivers this disease. rearrangements heterogeneous across osteosarcoma cases, the need genome-informed approach to targeted therapy. To identify...
Significance Stroke is the leading cause of disability in United States and has very limited treatment options. Brain stimulation techniques that promote recovery after stroke are a promising area research; however, current nonspecifically activate/inhibit target area, which not only leads to undesired side effects but also makes it difficult understand cell types mechanisms drive recovery. We used optogenetic technique specifically stimulate neurons demonstrate selective neuronal...
Neurogenesis persists in the olfactory bulb (OB) of adult mammalian brain. New interneurons are continually added to OB from subventricular zone (SVZ) via rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within OB, PK2 may also act detachment signal chain-migrating progenitors arriving RMS. deficiency mice leads marked reduction size, loss normal architecture, and accumulation These findings...
Circadian clocks drive daily rhythms in virtually all organisms. In mammals, the suprachiasmatic nucleus (SCN) is recognized as master clock that synchronizes central and peripheral oscillators to evoke circadian of diverse physiology behavior. How timing information transmitted from SCN generate overt essentially unknown. Prokineticin 2 ( PK2 ), a clock-controlled gene encodes secreted protein, has been indicated candidate output signal regulates locomotor rhythm. Here we report generation...
Coping with intermittent social stress is an essential aspect of living in complex environments. tends to counteract the deleterious effects and thought induce neuroadaptations corticolimbic brain systems. Here we test this hypothesis adult squirrel monkey males exposed separations new pair formations. These manipulations simulate conditions that typically occur male associations because competition for limited access residency mixed-sex groups. As evidence coping, previously confirmed...
Oxytocin is widely believed to be present and structurally identical in all placental mammals. Here, we report that multiple species of New World monkeys possess a novel form oxytocin, [P8] oxytocin. This mutation arises from substitution leucine proline amino acid position 8. Further analysis this Saimiri sciureus (squirrel monkey) indicates oxytocin transcribed translated properly. specific as the peptide sequence for arginine vasopressin, related nonapeptide, unaltered. These findings...
Background and Purpose: Stroke disrupts neuronal functions in both local remotely connected regions, leading to network-wide deficits that can hinder recovery. The thalamus is particularly affected, with progressive development of neurodegeneration accompanied by inflammatory responses. However, the complexity involved responses poorly understood. Herein we investigated spatiotemporal changes secondary degenerative after cortical stroke, using targeted transcriptome approach conjunction...
Stroke causes brain dysfunction and neuron death, the lack of effective therapies heightens need for new therapeutic targets. Here we identify prokineticin 2 (PK2) as a mediator cerebral ischemic injury. PK2 is bioactive peptide initially discovered regulator gastrointestinal motility. Multiple biological roles have been discovered, including circadian rhythms, angiogenesis, neurogenesis. However, role in neuropathology unknown. Using primary cortical cultures, found that mRNA up-regulated...
<h3>Importance</h3> Pediatric cancers are epigenetic diseases; therefore, considering tumor gene expression information is necessary for a complete understanding of the tumorigenic processes. <h3>Objective</h3> To evaluate feasibility and utility incorporating comparative into precision medicine framework difficult-to-treat pediatric young adult patients with cancer. <h3>Design, Setting, Participants</h3> This cohort study was conducted as consortium between University California, Santa Cruz...
Abstract KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities cancer, we performed RNAi screens primary spheroids derived from Kras mutant mouse cancer model and discovered an epigenetic regulator Ubiquitin-like containing PHD RING finger domains 1 (UHRF1). In human models UHRF1 knock-out selectively impaired growth induced apoptosis only cells. Genome-wide methylation gene expression analysis of UHRF1-depleted cells revealed global DNA hypomethylation leading...
Models to study metastatic disease in rare cancers are needed advance preclinical therapeutics and gain insight into biology. Osteosarcoma is a cancer with complex genomic landscape which outcomes for patients poor. As osteosarcoma genomes highly heterogeneous, multiple models fully elucidate key aspects of biology recapitulate clinically relevant phenotypes.
Abstract Juvenile myelomonocytic leukemia (JMML) is a hematologic malignancy of young children caused by mutations that increase Ras signaling output. Hematopoietic stem cell transplantation (HSCT) potentially curative treatment, but patients with relapsed or refractory (advanced) disease have dismal outcomes. This phase II trial evaluated the safety and efficacy trametinib, an oral MEK1/2 inhibitor, in advanced JMML. Ten infants were enrolled, objective response rate was 50%. Four proceeded...
Background and Purpose- Many restorative therapies have been used to study brain repair after stroke. These therapeutic-induced changes revealed important insights on recovery mechanisms; however, the intrinsic that occur in spontaneously stroke is less clear. The goal of this elucidate spontaneous stroke, by directly investigating transcriptome primary motor cortex mice naturally recovered Methods- Male C57BL/6J were subjected transient middle cerebral artery occlusion. Functional was...
Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central downstream effector pathways. Here we found microRNA (miRNA) cluster including miR181ab1 is a key modulator of oncogenesis. Ablation Mir181ab1 in genetically engineered mouse models Kras-driven lung and pancreatic cancer was deleterious tumor initiation progression. Expression both resident miRNAs cluster, miR181a1 miR181b1, necessary...
Abstract Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder that predominantly affects infants and young children. Hematopoietic stem cell transplantation (HSCT) standard of care, but post-HSCT relapse common, highlighting the need for innovative therapies. While adoptive immunotherapy with chimeric antigen receptor (CAR) T cells has improved outcomes patients advanced lymphoid malignancies, it not been comprehensively evaluated in JMML. In present study, we use bulk...
Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are promising stroke therapeutic, but creating ideal conditions treatment essential. Here we developed conductive polymer system stem cell delivery and electrical modulation in animals. Using this system, human transplants improve functional rodents. Increased endogenous production corresponds with improved function. Transcriptome analysis identified stanniocalcin 2...
Effective therapies for metastatic osteosarcoma (OS) remain a critical unmet need. Targeting mRNA translation in OS offers promising option, as selective drives the synthesis of cytoprotective proteins under harsh microenvironmental conditions to facilitate competence.
Many Veterans exposed to physical and psychological trauma experience symptoms of posttraumatic stress disorder (PTSD). As the etiology PTSD is complex, a better understanding underlying biological mechanisms may improve preventative care treatment for PTSD. Recent findings from fields neuroimaging epigenetics offer important insights into potential brain structures biochemical pathways modified gene expression associated with We combined epigenetic measures assess current by measuring...
Abstract Osteosarcoma (OS) is an aggressive bone cancer for which survival has not improved over three decades. While biomaterials have been widely used to engineer 3D soft‐tissue tumor models, the potential of engineering biomaterials‐based OS models comprehensive interrogation pathology and drug discovery remains untapped. Bone characterized by high mineral content, yet role in progression response unknown. Here, a microribbon‐based model with bone‐mimicking compositions developed...