A5029696043- Stress Responses and Cortisol
- Physiological and biochemical adaptations
- Spaceflight effects on biology
- Treatment of Major Depression
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Cardiac Arrest and Resuscitation
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Cerebrospinal fluid and hydrocephalus
- Neurogenesis and neuroplasticity mechanisms
- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Fetal and Pediatric Neurological Disorders
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Axon Guidance and Neuronal Signaling
- Dietary Effects on Health
- Selenium in Biological Systems
- Circadian rhythm and melatonin
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
Stanford University
2020-2025
University of California, Irvine
2017-2021
Subanesthetic ketamine is increasingly used for the treatment of varied psychiatric conditions, both on- and off-label. While it commonly classified as an N-methyl D-aspartate receptor (NMDAR) antagonist, our picture ketamine's mechanistic underpinnings incomplete. Recent clinical evidence has indicated, controversially, that a component efficacy subanesthetic may be opioid dependent. Using pharmacological functional ultrasound imaging in rats, we found blocking receptors suppressed...
Injectable 3D cell scaffolds possessing both electrical conductivity and native tissue-level softness would provide a platform to leverage electric fields manipulate stem behavior. Granular hydrogels, which combine jamming-induced elasticity with repeatable injectability, are versatile materials easily encapsulate cells form injectable niches. In this work, we demonstrate that electrically conductive granular hydrogels can be fabricated via simple method involving fragmentation of bulk...
Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are promising stroke therapeutic, but creating ideal conditions treatment essential. Here we developed conductive polymer system stem cell delivery and electrical modulation in animals. Using this system, human transplants improve functional rodents. Increased endogenous production corresponds with improved function. Transcriptome analysis identified stanniocalcin 2...
Cardiac arrest (CA) affects >550,000 people annually in the United States whereas 80-90% of survivors suffer from a comatose state. Arousal coma is critical for recovery, but mechanisms arousal are undefined. Orexin-A, hypothalamic excitatory neuropeptide, has been linked to deficits various brain injuries. We investigated orexinergic system's role recovery CA-related neurological impairments, including deficits. Using an asphyxial CA and resuscitation model rats, we examine...
Background: Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiological stress response triggered an obesogenic diet. Furthermore, this directly determined combined impact short-term diet adolescence on critical behavioral molecular substrates...
While interest toward caloric restriction (CR) in various models of brain injury has increased recent decades, studies have predominantly focused on the benefits chronic or intermittent CR. The effects ultra-short, including overnight, CR acute ischemic are not well studied. Here, we show that overnight (75% over 14 h) prior to asphyxial cardiac arrest and resuscitation (CA) improves survival neurological recovery as measured by, behavioral testing deficit scores, faster quantitative...
Abstract Ultrasound-activatable drug-loaded nanocarriers enable noninvasive and spatiotemporally-precise on-demand drug delivery throughout the body. However, most systems for ultrasonic uncaging utilize cavitation or heating as release mechanism often incorporate relatively exotic excipients into formulation that together limit drug-loading potential, stability, clinical translatability applicability of these systems. Here we describe an alternate strategy design such in which acoustic...
ABSTRACT Background Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiological stress response triggered an obesogenic diet. Furthermore, this directly determined combined impact short-term diet adolescence on critical behavioral molecular...
Stanniocalcin-2 (STC-2) is a glycoprotein implicated in multiple physiological pathways, including calcium and phosphate homeostasis, cell proliferation, anti-inflammatory responses. The molecular mechanisms by which STC-2 functions the brain its specific roles various neurological processes are not well-defined. We have previously shown that intraventricular administration of post-stroke increases endogenous stem production improves functional recovery an adult rodent model distal middle...
Introduction (Abstract) Impaired clearance of the byproducts aging and neurologic disease from brain exacerbates progression severity. We have developed a noninvasive, low intensity transcranial focused ultrasound protocol that facilitates removal pathogenic substances cerebrospinal fluid (CSF) interstitium. This clears neurofilament light chain (NfL) – an byproduct in aged mice red blood cells (RBCs) central nervous system two mouse models hemorrhagic injury. Cleared RBCs accumulate...
Abstract While interest toward caloric restriction (CR) in various models of brain injury has increased recent decades, studies have predominantly focused on the benefits chronic or intermittent CR. The effects ultra-short, including overnight, CR acute ischemic injury, however, are not well studied. Here, we show that overnight (75% over 14 h) prior to asphyxial cardiac arrest and resuscitation (CA) improves survival neurological recovery, complete prevention neurodegeneration multiple...
Abstract Subanesthetic ketamine rapidly and robustly reduces depressive symptoms in patients with treatment-resistant depression. While it is commonly classified as an N -methyl D-aspartate receptor (NMDAR) antagonist, our picture of ketamine’s mechanistic underpinnings incomplete. Recent clinical evidence has indicated, controversially, that a component the efficacy depression may be opioid dependent. Using pharmacological functional ultrasound imaging rats, we found blocking receptors...
Effective stroke recovery therapeutics remain limited. Stem cell therapies have yielded promising results, but the harsh ischemic environment of post-stroke brain reduces their therapeutic potential. Previously, we developed a conductive polymer scaffold system that enabled stem delivery with simultaneous electrical modulation cells and surrounding neural environment. This wired proved efficacious in optimizing ideal conditions for mediated motor improvements rodent model stroke. To further...
Introduction: During cardiac arrest (CA), a major goal of responders is to ascertain the likelihood successful cardiopulmonary resuscitation (CPR) and optimize efforts accordingly achieve return spontaneous circulation (ROSC). Pulseless electrical activity (PEA), common form CA in inpatient settings, often allows monitoring heart rate (HR) immediately preceding (CPR). We were interested assessing role HR during PEA outcome CPR. To evaluate this controlled setting, we used rodent model...
Introduction: Caloric restriction (CR) has been widely shown to have both cardioprotective and neuroprotective properties. However, nearly all studies investigated chronic CR with mechanisms linked the upregulation of SIRT-1 BDNF. Minimal no focus placed on potential benefits transient in models brain injury, including stroke. Furthermore, effects cardiac arrest-induced global cerebral ischemia not evaluated. We overnight (~14-hour) survival neurological outcome a rodent model arrest (CA)....
Enhancing an endogenous stem cell response is a promising approach to improve stroke recovery. We have previously shown that conductive polymer cannula system for human delivery and electrical stimulation of the post-stroke environment increases production improves functional recovery in rodent model distal middle cerebral artery occlusion (dMCAO). Transcriptomic analyses coupled with lentiviral manipulation identified stanniocalcin 2 (STC-2) as one key mediator this improvement. To further...