A5086463124- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Retinal Development and Disorders
- Advanced Drug Delivery Systems
- HIV/AIDS Research and Interventions
- Meningioma and schwannoma management
- Photochromic and Fluorescence Chemistry
- Neurofibromatosis and Schwannoma Cases
- Photonic Crystal and Fiber Optics
- Connective Tissue Growth Factor Research
- S100 Proteins and Annexins
- Photodynamic Therapy Research Studies
Stanford University
2017-2024
Palo Alto University
2019
University of Missouri–Kansas City
2013-2017
Abstract On April 10, 2020, the FDA approved selumetinib (KOSELUGO, AstraZeneca) for treatment of pediatric patients 2 years age and older with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas. Approval was based on demonstration a durable overall response rate per Response Evaluation in Neurofibromatosis Schwannomatosis criteria supported by observed clinical improvements neurofibroma–related symptoms functional impairments 50 neurofibromas single-arm,...
Abstract The application of induced pluripotent stem cells (iPSCs) in disease modeling and regenerative medicine can be limited by the prolonged times required for functional human neuronal differentiation traditional 2D culture techniques. Here, a conductive graphene scaffold (CGS) to modulate mechanical electrical signals promote iPSC‐derived neurons is presented. soft CGS with cortex‐like stiffness (≈3 kPa) stimulation (±800 mV/100 Hz 1 h) incurs fivefold improvement rate (14d) generating...
Nanofiber was explored as a stent surface coating substance for the treatment of coronary artery diseases (CAD). Nanofibers loaded with nanoparticles containing β-estradiol were developed and exploited to prevent stent-induced restenosis through regulation reactive oxygen species (ROS). Eudragit S-100 (ES), versatile polymer, used nanoparticle (NP) base, mixtures hexafluoro-2-propanol (HFIP), PLGA PLA at varying ratios nanofiber base. β-Estradiol primary compound alleviate ROS activity...
Human induced pluripotent stem cell-derived neural progenitor cells (hNPCs) are a promising cell source for transplantation to treat neurological diseases such as stroke and peripheral nerve injuries. However, there have been limited studies investigating how the dimensionality of physical electrical microenvironment affects hNPC function. In this study, we report fabrication two- three-dimensional (2D 3D respectively) constructs composed conductive polymer compare effect stimulation...
Extracellular matrix (ECM) properties affect multiple cellular processes such as cell survival, proliferation, and protein synthesis. Thus, a polymeric-cell delivery system with the ability to manipulate extracellular environment can act fundamental regulator of function. Given promise stem therapeutics, method uniformly enhance function, in particular trophic factor release, prove transformative improving efficacy increasing feasibility by reducing total number cells required. Herein,...
Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are promising stroke therapeutic, but creating ideal conditions treatment essential. Here we developed conductive polymer system stem cell delivery and electrical modulation in animals. Using this system, human transplants improve functional rodents. Increased endogenous production corresponds with improved function. Transcriptome analysis identified stanniocalcin 2...
Electrical gradients are fundamental to physiological processes including cell migration, tissue formation, organ development, and response injury regeneration. Current electrical modulation of cells is primarily studied under a uniform field. Here we demonstrate the fabrication conductive gradient hydrogels (CGGs) that display mechanical properties varying local mimicking conditions. The electrically-stimulated CGGs enhanced human mesenchymal stem (hMSC) viability attachment. Cells on...
This study was aimed to develop and evaluate a smart nanosystem that targeted photothermal ablation of inflammatory macrophages in atherosclerotic plaque. Mannosylated-reduced graphene oxide (Man-rGO) synthesized using three step procedures: (1) preparation ox-GOs, (2) microwave-assisted synthesis PEI-rGOs, (3) mannosylation PEI-rGO reductive amination reaction (Man-rGOs). The ζ-potential Man-rGO signifies electrophoretic mobility the charged surface examined Zetasizer Nano ZS. effects on...
Stem cell therapy has emerged as an exciting stroke therapeutic, but the optimal delivery method remains unclear. While technique of microinjection been used for decades to deliver stem cells in models, this is limited by lack ability manipulate prior injection. This paper details a using electrically conductive polymer scaffold delivery. Electrical stimulation alters cell's genes involved survival, inflammatory response, and synaptic remodeling. After electrical preconditioning, on are...
Stem cell therapy has emerged as an exciting stroke therapeutic, but the optimal delivery method remains unclear. While technique of microinjection been used for decades to deliver stem cells in models, this is limited by lack ability manipulate prior injection. This paper details a using electrically conductive polymer scaffold delivery. Electrical stimulation alters cell's genes involved survival, inflammatory response, and synaptic remodeling. After electrical preconditioning, on are...
Effective stroke recovery therapeutics remain limited. Stem cell therapies have yielded promising results, but the harsh ischemic environment of post-stroke brain reduces their therapeutic potential. Previously, we developed a conductive polymer scaffold system that enabled stem delivery with simultaneous electrical modulation cells and surrounding neural environment. This wired proved efficacious in optimizing ideal conditions for mediated motor improvements rodent model stroke. To further...
Introduction: Brain stimulation techniques to enhance stroke recovery are a promising area of research; however, in vivo electrical combined with neural progenitor cell (NPC) transplantation has not been fully investigated. We propose the use conductive polymer scaffold optimize stem therapy and determine mechanisms driving recovery. Methods: The system consisting polypyrrole was seeded NPCs (Aruna Biomedical) implanted along reference electrode ( Fig. 1a ). Immunocompromised rats underwent...