A5011255175- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Bone health and osteoporosis research
- Retinal Diseases and Treatments
- Diabetes Management and Research
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Genetic Associations and Epidemiology
- Pituitary Gland Disorders and Treatments
- Bone health and treatments
Chinese University of Hong Kong
1998-2025
Queen Mary Hospital
2015-2025
University of Hong Kong
2016-2025
Astellas Pharma (United States)
2025
Hong Kong Baptist University
2025
Sunchon National University
2024
Chapman University
2024
State Key Laboratory of Pharmaceutical Biotechnology
2023
University of Missouri–Kansas City
2007-2022
Gachon University
2017-2021
In rodents, brown adipose tissue (BAT) regulates cold- and diet-induced thermogenesis (CIT; DIT). Whether BAT recruitment is reversible how it impacts on energy metabolism have not been investigated in humans. We examined the effects of temperature acclimation BAT, balance, substrate a prospective crossover study 4-month duration, consisting four consecutive blocks 1-month overnight (24 °C [month 1] → 19 2] 24 3] 27 4]) five healthy men temperature-controlled research facility. Sequential...
Abstract Objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related thyroiditis is increasingly recognized. The role of thyroid autoimmunity and SARS-CoV-2 viral load in SARS-CoV-2–related dysfunction unclear. We evaluated the function a cohort disease 2019 (COVID-19) patients, relation to their clinical features, biochemical, immunological, inflammatory markers. Methods Consecutive adult without known disorders, admitted Queen Mary Hospital for COVID-19 from July 21...
The contribution of brown adipose tissue (BAT) to the energy balance in humans exposed sustainable cold has not been completely established, partially because measurement limitations both BAT activity and expenditure (EE).The objective study was characterize role activation cold-induced thermogenesis (CIT).This a single-blind, randomized crossover intervention.The conducted at National Institutes Health Clinical Center.Thirty-one healthy volunteers participated study.The intervention...
Background The optimal reference range of homeostasis model assessment insulin resistance (HOMA-IR) in normal Chinese population has not been clearly defined. Here we address this issue using the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), a prospective population-based cohort study with long-term follow-up. Material & Methods In study, glucose tolerance (NGT), impaired fasting (IFG), (IGT) and type 2 diabetes mellitus (T2DM) were defined according to 1998 World Health...
Existing studies reported the potential prognostic role of non-thyroidal illness syndrome (NTIS), characterized by low triiodothyronine (T3) with normal/low thyroid-stimulating hormone (TSH), mainly in severe COVID-19. None considered significant impact SARS-CoV-2 viral load on adverse outcomes. We aimed to clarify NTIS among predominantly mild-to-moderate COVID-19 patients.A prospective study patients.Consecutive adults admitted Queen Mary Hospital for confirmed from July December 2020 were...
Background: Thyroiditis and Graves' disease have been reported after coronavirus 2019 (COVID-19) vaccination. We evaluated the risks of adverse events COVID-19 vaccination among patients treated for hypothyroidism. Methods: In this retrospective population-based cohort study Hong Kong Hospital Authority electronic health records with Department Health linkage, levothyroxine (LT4) users were categorized into unvaccinated, vaccinated BNT162b2 (mRNA vaccine), or CoronaVac (inactivated vaccine)...
Flash memory offers attractive features for storage of data, such as non-volatility, shock resistance, fast access speed, and low power consumption. However, it requires erasing before can be overwritten. The erase operations are slow consume comparatively a great deal power. Furthermore, flash only erased limited number times. To overcome hardware limitations, we use the non-in-place update mechanism that cleaner to reclaim space occupied by obsolete data. improve cleaning performance...
The purpose of this study is to investigate the risk factors for recurrence after successful percutaneous endoscopic lumbar discectomy (PELD). Recently, PELD has become most common surgical technique. However, there are only a few studies on causing reappearance symptoms. Between January 2002 and December 2004, 42 patients with recurrent disc herniation were classified as group who underwent satisfactory result randomly selected non-recurrent group. For all patients, we analyzed medical...
Recently, interspecies quorum quenching by bacterial cells has been reported as a novel approach to the biofouling control in membrane bioreactor (MBR) for wastewater treatment. In this study, (QQ) bacterium, Pseudomonas sp. 1A1, was isolated from lab-scale MBR and encapsulated microbial vessel made of hollow fiber microporous MBR. 1A1 most likely produce AHL-acylase degraded wide range N-acyl homoserine lactones (AHLs), although there large difference degradation rate each AHL. It an...
Elevated fibroblast growth factor 21 (FGF21) levels have been suggested, from cross-sectional studies, as an indicator of subclinical diabetic nephropathy. We investigated whether serum FGF21 was predictive the development nephropathy.Baseline were measured in 1136 Chinese type 2 subjects recruited Hong Kong West Diabetes Registry. The role predicting decline estimated glomerular filtration rate (eGFR) over a median follow-up 4 years analyzed using Cox regression analysis.At baseline,...
Tannic acid (TA), a naturally occurring polyphenol, is potent anti-oxidant with anti-proliferative effects on multiple cancers. However, its ability to modulate gene-specific expression of tumour suppressor genes and oncogenes has not been assessed. This work investigates the mechanism TA regulate canonical non-canonical STAT pathways impose induction G1-arrest apoptosis. Regardless p53 status membrane receptors, induced apoptosis in breast cancer cells. distinctly modulated both pathways,...