A5021685899- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Eicosanoids and Hypertension Pharmacology
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Natural Antidiabetic Agents Studies
- Ethics in Clinical Research
- Inflammatory mediators and NSAID effects
- Health and Medical Research Impacts
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Kruppel-like factors research
- Bone health and treatments
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Artificial Intelligence in Healthcare and Education
- Bone Metabolism and Diseases
- Advanced Glycation End Products research
- Genomics and Rare Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
Johns Hopkins Medicine
2022-2023
Johns Hopkins University
2022-2023
University of Hong Kong
2007-2022
Queen Mary Hospital
2007-2015
Elevated fibroblast growth factor 21 (FGF21) levels have been suggested, from cross-sectional studies, as an indicator of subclinical diabetic nephropathy. We investigated whether serum FGF21 was predictive the development nephropathy.Baseline were measured in 1136 Chinese type 2 subjects recruited Hong Kong West Diabetes Registry. The role predicting decline estimated glomerular filtration rate (eGFR) over a median follow-up 4 years analyzed using Cox regression analysis.At baseline,...
APPL1 is an adaptor protein that binds to both AKT and adiponectin receptors hypothesised mediate the effects of in activating downstream effectors such as AMP-activated kinase (AMPK). We aimed establish whether plays a physiological role mediating glycogen accumulation insulin sensitivity muscle signalling pathways involved. In vivo electrotransfer cDNA- shRNA-expressing constructs was used over-express or silence for 1 week single tibialis cranialis muscles rats. Resulting changes glucose...
Obstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise A-FABP upregulated OSA. A total 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited underwent polysomnography. Serum levels showed significant positive correlations duration oxygen...
Abstract Background Circulating thrombospondin-2 (TSP2) levels were associated with the development of heart failure (HF) in recent studies. However, these studies included only a minority patients type 2 diabetes, which is an increased HF risk. As hyperglycemia induces TSP2 expression and its tissue increases we investigated prospective association circulating incident hospitalization (HHF), associations longitudinal changes echocardiographic parameters diabetes. Methods Baseline serum...
Abstract Aim To study whether plasma fibroblast growth factor 21 independently predicts the risk of end‐stage renal disease in Asian people with Type 2 diabetes. Methods In this prospective cohort study, 1700 diabetes were followed for a mean 6.3 years regional hospital Singapore. Incident was identified by linkage national registry. The association baseline levels progression to studied using survival analyses. Results Participants aged 60 ± 10 years, an average duration 12 years. Their...
Background Kidney biopsies are procedures commonly performed in clinical nephrology and increasingly used research. In this study, we aimed to evaluate the experiences of participants who underwent research kidney Precision Medicine Project (KPMP). Methods KPMP with AKI or CKD were enrolled at nine recruitment sites United States between September 2019 January 2023. At 28 days postbiopsy, invited complete a survey share their experiences, including motivation participate research,...