Stephen J Leslie
A5047624828- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Mobile Health and mHealth Applications
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Complementary and Alternative Medicine Studies
- Digital Mental Health Interventions
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and Mental Health
- Healthcare professionals’ stress and burnout
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- EEG and Brain-Computer Interfaces
- Cardiac, Anesthesia and Surgical Outcomes
- Health Literacy and Information Accessibility
- Medication Adherence and Compliance
Raigmore Hospital
2016-2025
NHS Highland
2016-2025
The University of Melbourne
1998-2025
Melbourne Genomics Health Alliance
2025
Walter and Eliza Hall Institute of Medical Research
2024
University of Colorado Anschutz Medical Campus
2024
RELX Group (United States)
2024
University of the Highlands and Islands
2015-2023
Letterkenny University Hospital
2023
University of Edinburgh
2001-2022
High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis myocardial infarction, but whether this improves clinical outcomes is unknown. We aimed to determine introduction a high-sensitivity I (hs-cTnI) assay with sex-specific 99th centile diagnostic threshold would reduce subsequent infarction or cardiovascular death in patients suspected acute coronary syndrome.In stepped-wedge, cluster-randomised controlled trial across ten secondary tertiary care hospitals...
Background: The introduction of more sensitive cardiac troponin assays has led to increased recognition myocardial injury in acute illnesses other than coronary syndrome. Universal Definition Myocardial Infarction recommends high-sensitivity testing and classification patients with based on pathogenesis, but the clinical implications implementing this guideline are not well understood. Methods: In a stepped-wedge cluster randomized, controlled trial, we implemented assay recommendations 48...
High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the safety and efficacy of this approach is uncertain. We investigated whether an early rule-out pathway safe effective for patients with suspected acute coronary syndrome.
OBJECTIVE: To determine the relation of hamstring and quadriceps muscle strength imbalance to injury using a prospective observational cohort study METHOD: A total 102 senior male Australian Rules footballers aged 22.2 (3.6) years were tested at start football season. Maximum voluntary concentric eccentric torque muscles both legs was assessed Kin-Com isokinetic dynamometer angular velocities 60 180 degrees/second. Twelve (11.8%) players sustained clinically diagnosed strains which caused...
The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, identification of true predisposing gene(s) has been handicapped by strong linkage disequilibrium across region. Furthermore, most studies to date have limited examination a subset HLA and non-HLA genes with marker density sample size insufficient mapping all independent association signals. We genotyped panel 1,472 SNPs capture common genomic variation 3.44 megabase (Mb) classic region in 10,576...
Major disparities between women and men in the diagnosis, management, outcomes of acute coronary syndrome are well recognized.The aim this study was to evaluate impact implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial infarction suspected syndrome.Consecutive patients were enrolled stepped-wedge, cluster-randomized controlled trial across 10 hospitals. Myocardial injury defined as concentration >99th centile 16 ng/l 34 men. The...
The epidemiology of peripartum cardiomyopathy (PPCM) in Europe is poorly understood and data on long-term outcomes are lacking. A retrospective, observational, population-level study validated cases PPCM Scotland from 1998 to 2017 was conducted.Women hospitalized with presumed de novo left ventricular systolic dysfunction around the time pregnancy no clear alternative cause were included. Each case matched 10 controls. Incidence risk factors identified. Morbidity mortality examined mothers...
Takotsubo syndrome is an increasingly common cardiac emergency with no known evidence-based treatment. The purpose of this study was to investigate cardiovascular mortality and medication use after takotsubo syndrome. In a case-control study, all patients in Scotland between 2010 2017 (n = 620) were age, sex, geographically matched individuals the general population (1:4, n 2,480) contemporaneous acute myocardial infarction (1:1, 620). Electronic health record data linkage outcomes drug...
ABSTRACT Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart cases globally, and this incidence is increasing due to extended lifespans accumulating comorbidities. Emerging evidence suggests that Wnt signaling plays a role in cardiomyocyte hypertrophy cardiac fibrosis, which are key features HFpEF. Furthermore, Porcupine (PORCN) inhibitors, negatively regulate signaling, have shown promising results improving function reducing and/or fibrosis. This...
Abstract Background Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease angina. Despite this important service provision, continues to be under-diagnosed many are left untreated at risk. Recent advances in imaging technology now led widespread use noninvasive computed tomography, which can used measure artery calcium scores perform angiography one examination. However, has not been robustly evaluated its application...