A5037792935- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Aortic aneurysm repair treatments
- Education, Psychology, and Social Research
- Ion channel regulation and function
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Renal and Vascular Pathologies
- Vascular Procedures and Complications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Aortic Disease and Treatment Approaches
- Central Venous Catheters and Hemodialysis
- Wireless Sensor Networks for Data Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Genomics and Rare Diseases
- Peripheral Artery Disease Management
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
Masaryk University
2015-2024
University Hospital Brno
2012-2024
St. Anne's University Hospital Brno
2010-2024
Ocní klinika
1998-2021
Central European Institute of Technology – Masaryk University
2019
Národný Onkologický Ústav
2019
Medical University of Lodz
2019
RECETOX
2017
Brno University of Technology
2015
Czech Technical University in Prague
2007
The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed assess current clinical effectiveness primary prevention ICD therapy.We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated (DCM) guideline indications for prophylactic implantation. endpoint all-cause...
The time lag of the QT interval adaptation to heart rate changes (QT/RR hysteresis) was studied in 40 healthy subjects (18 females; mean age, 30.4+/-8.1 yr) with 3 separate daytime (>13 h) 12-lead electrocardiograms (ECG) each subject. In recording, 330 individual 10-s ECG segments were measured, including 100 preceded by 2 min varying greater than +/-2 beats/min. Other a stable rate. variable rate, QT/RR hysteresis characterized lambda parameters exponential decay models. intrasubject SDs...
Abstract Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability intervals reduces the utility monitoring strategies. Since this partly related to QT heart rate correction, 10 corrections (Bazett, Fridericia, Dmitrienko, Framingham, Schlamowitz, Hodges, Ashman, Rautaharju, Sarma, and Rabkin) were applied 452,440 ECG measurements made 539 healthy volunteers (259 females, mean age 33.3 ± 8.4 years). For each correction formula, short...
Background Molecular genetic testing is recommended for diagnosis of inherited cardiac disease, to guide prognosis and treatment, but access often limited by cost availability. Recently introduced high-throughput bench-top DNA sequencing platforms have the potential overcome these limitations. Methodology/Principal Findings We evaluated two next-generation (NGS) molecular diagnostics. The protein-coding regions six genes associated with arrhythmia syndromes were amplified from 15 human...
Abstract The Novel Foods Risk Assessment Data Modelling and Extraction (NORA) project, commissioned by the European Food Safety Authority (EFSA) implemented EcoMole s.r.o., aimed to develop a structured database support risk assessment process for novel foods (NF). project encompassed three key objectives: (1) designing comprehensive data model NF opinions, leveraging extending existing frameworks like OpenFoodTox 2.0; (2) extracting integrating from published opinions into database; (3)...
Sex differences are known in several facets of cardiac electrophysiology, mostly concerning myocardial repolarisation. In this study, heart rate and variability (HRV) responses to postural provocations were compared 175 176 healthy females males, respectively (aged 33.1 ± 9.1 years). Two different provocative tests with position changes supine→sitting→standing→supine supine→standing→sitting→supine (15-min standing, 10-min other positions) performed up 4 times each subject. Heart spectral...
Abstract Aims Fragmented QRS complex with visible notching on standard 12-lead electrocardiogram (ECG) is understood to represent depolarization abnormalities and signify risk of cardiac events. Depolarization similar prognostic implications likely exist beyond visual recognition but no technology presently suitable for quantification such invisible ECG abnormalities. We present a technology. Methods results A signal processing method projects all leads the into optimized three perpendicular...
Abstract On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, dynamics a clear candidate for non-invasive assessment atrial abnormalities including risk fibrillation. We studied in 599 healthy subjects (aged 33.5 ± 9.3 years, 288 females) whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 samples selected (1256 244 per subject) measure...
Increased spatial angle between QRS complex and T wave loop orientations has repeatedly been shown to predict cardiac risk. However, there is no consensus on the methods for calculation of angle. This study compared reproducibility predictive power three most common ways QRS-T assessment. Electrocardiograms 352 healthy subjects, 941 survivors acute myocardial infarction (MI), 605 patients recorded prior implantation automatic defibrillator [implantable cardioverter (ICD)] were used obtain...
BACKGROUND: Subtle, prognostically important ECG features may not be apparent to physicians. In the course of supervised machine learning, thousands are identified. These limited conventional parameters and morphology. We aimed investigate whether neural network–derived could used predict future cardiovascular disease mortality have phenotypic genotypic associations. METHODS: extracted 5120 from an artificial intelligence–enabled model trained for 6 simple diagnoses applied unsupervised...
Abstract Background Bazett formula is frequently used in paediatric screening for the long QT syndrome (LQTS) and proposals exist that using standing rather than supine electrocardiograms (ECG) improves sensitivity of LQTS diagnosis. Nevertheless, compared to adults, children have higher heart rates (especially during postural provocations) correction also known lead artificially prolonged QTc values at increased rates. This study assessed incidence erroneously normal without abnormalities....
Accurate evaluation of the appearance QTc sex differences during childhood and adolescence is intricate. Inter-subject individual QT/RR patterns make generic heart rate corrections inaccurate because fast resting rates in children. The study investigated 527 healthy children adolescents aged 4 to 19 years (268 females, 50.9%). All underwent continuous ECG 12-lead monitoring while performing postural changes a 70-minute investigative protocol obtain QT interval measurements at different...
Abstract Aims The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. EUropean Comparative Effectiveness Research to Assess the Use Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims assess its current value. Methods and results EU‐CERT‐ICD a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries....