A5056983761- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Vagus Nerve Stimulation Research
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Muscle activation and electromyography studies
- Patient Satisfaction in Healthcare
- Primary Care and Health Outcomes
- Receptor Mechanisms and Signaling
University Medical Center
2014-2025
University of Göttingen
2014-2024
German Centre for Cardiovascular Research
2014-2024
Universitätsmedizin Göttingen
2015-2024
Nephrologisches Zentrum Goettingen
2008-2018
Heidelberg University
2017
University Hospital Heidelberg
2017
University Medical Center Utrecht
2017
Schwarzwald-Baar Klinikum
2010
Medizinische Hochschule Hannover
2010
In chronic heart failure (CHF), reduced vagal activity correlates with increased mortality and acute decompensation. Experimentally, vagus nerve stimulation (VNS) improved left ventricular (LV) function survival; clinically, it is used for the treatment of drug-refractory epilepsy. We assessed safety tolerability VNS in symptomatic CHF patients, using a novel implantable system. The secondary goal was to obtain preliminary data on clinical efficacy. This multi-centre, open-label phase II,...
This study tested the correlation of QT and JT dispersion other potentially useful electrocardiographic (ECG) indexes with repolarization recovery time. Dispersion ventricular is currently being assessed noninvasively from surface ECG by means dispersion, although their as measured directly myocardium not well established. Multiple monophasic action potentials were recorded simultaneously a 12-lead isolated Langendorff-perfused rabbit hearts. The was compared potential duration at 90%...
Background —Risk stratification by means of analysis QT dispersion (QTD) in the 12-lead surface ECG is under intense investigation various patient populations. The aim present prospective study was to evaluate prognostic value QTD and other variables reflecting ventricular repolarization comparison with established risk stratifiers during long-term follow-up a large cohort post–myocardial infarction patients treated according contemporary therapeutic guidelines. Methods Results —In 280...
The stratification of post-myocardial infarction (MI) patients at risk sudden cardiac death remains important. aim the present study was to assess prognostic value novel T-wave morphology descriptors derived from resting 12-lead ECGs.In 280 consecutive post-MI patients, a ECG recorded before discharge, optically scanned, and digitized. For study, 5 were automatically calculated after singular decomposition signal. total cosine R-to-T (TCRT [describes global angle between repolarization...
Objectives:It is now well recognized that myocardial stretch can cause arrhythmias due to stretch-induced depolarizations. The effects of transient applied during the various phases cardiac action potential have not been investigated. This study (1) examined short pulses and sustained on monophasic (MAP) repolarization time course diastolic potential, (2) arrhythmic response differently timed pulses, (3) tested by comparison with computer simulations whether these are compatible...
T Wave Alternans for Risk Stratification. Introduction : The current standard arrhythmic risk stratification is electrophysiologic (EP) testing, which, due to its invasive nature, limited patients already known be at high risk. A number of noninvasive tests, such as determination left ventricular ejection fraction (LVEF) or heart rate variability, have been evaluated additional stratifiers. Microvolt wave alternans (TWA) a promising new marker. Prospective evaluation markers in low‐...
Defibrillator lead malfunction is a potential long-term complication in patients with an implantable cardioverter-defibrillator (ICD). The aim of this study was to determine the incidence and causes necessitating surgical revision evaluate 2 approaches treat malfunction.We included 1317 consecutive ICD implanted at 3 European centers between 1993 2004. types were recorded. If integrity high-voltage part could be ascertained, additional pace/sense implanted. Otherwise, received new lead. Of...
The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed assess current clinical effectiveness primary prevention ICD therapy.We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated (DCM) guideline indications for prophylactic implantation. endpoint all-cause...
Heart rate variability (HRV) has now been investigated for a number of decades. Different investigations linked HRV to the autonomic nervous system (ANS). Among these links, two clearly distinct facets need be distinguished. Ongoing debate relates used as measure tone. Nevertheless, this is very different from present discussion which deals with an indicator responsiveness, i.e. usefulness assessing whether ANS responds provocations and can detect changes in influence. control sinus node...
T Wave Alternans in Humans. Introduction: Evidence is accumulating that microvolt wave alternans (TWA) a marker of increased risk for ventricular tachyarrhythmias. Initially, atrial pacing was used to elevate heart rate and elicit TWA. More recently, noninvasive approach has been developed elevates using exercise. Methods Results: In 30 consecutive patients with history tachyarrhythmias, the spectral method detect TWA during both submaximal exercise testing. The concordance presence or...
Background — The aim of the present study was to assess prognostic value novel repolarization descriptors from 12-lead ECG in a large cohort US veterans. Methods and Results Male veterans (n=813) with cardiovascular disease had digital ECGs recorded at VA Medical Center, Washington, DC, between 1984 1991. patient series retrospectively compiled 1991; follow-up prospectively assessed until 2000. Novel variables characterizing T-wave loop were automatically analyzed. Of 772 patients...
BACKGROUND Thrombolysis has become the standard therapeutic approach in patients with acute myocardial infarction. To identify who may benefit from early invasive procedures, reliable noninvasive assessment of success or failure thrombolytic therapy is mandatory. METHODS AND RESULTS In a prospective study 63 consecutive undergoing thrombolysis for their first infarction, serial measurements creatine kinase (CK), its isoenzyme CK-MB, myoglobin, and troponin T were done to determine value...
BACKGROUND Successful reperfusion of the infarct-related artery in patients with acute myocardial infarction has been shown to reduce in-hospital as well 1-year mortality. Besides thrombolysis-induced salvage, there is increasing evidence that an open results increased electrical stability heart and this effect at least part responsible for favorable long-term outcome these patients. The exact incidence arrhythmic events during first year after predictive value different risk factors...
Therapy with an implantable cardioverter defibrillator (ICD) is established for the prevention of sudden cardiac death (SCD) in high risk patients. We aimed to determine effectiveness primary ICD therapy by analysing registry data from 14 centres 11 European countries compiled between 2002 and 2014, emphasis on outcomes women who have been underrepresented all trials.Retrospective local registries implantations 2014 were a central database. Predefined outcome measures overall mortality first...
AimsWith the expanding indications for implantable cardioverter defibrillator (ICD) and reports of unexpected ICD failures, home monitoring (HM) was proposed to decrease follow-up workload increase patient safety. Home defibrillators offer wireless, everyday transfer status therapy data a central HM Service Center, which notifies attending physician relevant events. We evaluated functionality safety ICDs.