Péter Perge
A5081624230- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Gout, Hyperuricemia, Uric Acid
- Advanced Neural Network Applications
- Cardiovascular Health and Risk Factors
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Laser-induced spectroscopy and plasma
- Urticaria and Related Conditions
- Coronary Interventions and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Law, logistics, and international trade
- Heart Rate Variability and Autonomic Control
Semmelweis University
2016-2025
United Heart and Vascular Clinic
2022
The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed assess current clinical effectiveness primary prevention ICD therapy.We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated (DCM) guideline indications for prophylactic implantation. endpoint all-cause...
Our aim was to develop a machine learning (ML)-based risk stratification system predict 1-, 2-, 3-, 4-, and 5-year all-cause mortality from pre-implant parameters of patients undergoing cardiac resynchronization therapy (CRT).
BACKGROUND: High-power short-duration ablation has shown impressive efficacy and safety for pulmonary vein isolation (PVI); however, initial results with very high power were discouraging. This study compared the long-term durability of PVI performed a 90- versus 50-W setting. METHODS: Patients randomized 1:1 to undergo QDOT catheter using setting 90 or 50 W. Three months after index procedure, patients underwent repeat electrophysiology identify reconnections. followed 12 detect AF...
Introduction Our pilot study aimed to evaluate the role of local impedance drop in lesion formation during pulmonary vein isolation with a novel contact force sensing ablation catheter that records as well and find cut-off value predicts successful formation. Materials methods After completing point-by-point radiofrequency isolation, success applications was evaluated by pacing along line at 10 mA, 2 ms pulse width. Lesions were considered if loss capture achieved. Results Out 645...
High-power short-duration (HPSD) radiofrequency ablation has been proposed to produce rapid and effective lesions for pulmonary vein isolation (PVI). We aimed evaluate the procedural characteristics first-pass (FPI) rate of HPSD very high-power (vHPSD) compared low-power long-duration (LPLD) technique. One hundred fifty-six patients with atrial fibrillation (AF) were enrolled assigned LPLD, HPSD, or vHPSD PVI. The energy setting was 30, 50, 90 W in groups, respectively. In group, W/4 s...
Abstract Aims Cerebral thrombo-embolism is a dreaded complication of pulmonary vein isolation (PVI) for atrial fibrillation; its surrogate, silent cerebral embolism (SCE) can be detected by diffusion-weighted brain magnetic resonance imaging (bMRI). Initial investigations have raised concern that very high-power, short-duration (vHPSD; 90 W/4 s) temperature-controlled PVI with the QDOT Micro catheter may associated higher incidence SCE compared low-power long-duration ablation. We aimed to...
According to current guidelines, pulmonary vein isolation as first-line therapy should be considered for patients with atrial fibrillation (AF), however, optimal timing of the procedure is still unknown in heart failure (HF). We aimed evaluate effect early catheter ablation (CA) HF and left ventricular ejection fraction (LVEF) below 50%.
AimsThe low lymphocyte counts and high neutrophil leucocyte fractions have been associated with poor prognosis in chronic heart failure. We hypothesized that the baseline ratio of leucocytes to lymphocytes (NL ratio) would predict outcome failure patients undergoing cardiac resynchronization therapy (CRT).
Rationale The beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response cellular insults. To this end, increased protein O-GlcNAcylation improves short-term survival cardiomyocytes subjected acute injury. This observation has been repeated by multiple groups and in models; however, whether plays beneficial role more chronic settings remains an open question. Objective Here, we queried increasing levels cardiac would be during infarct-induced heart failure....
Nowadays, a novel contact-force guided ablation technique is used for enclosing pulmonary veins in patients with atrial fibrillation (AF). We sought to determine whether left (LA) wall thickness (LAWT) and vein (PV) dimensions, as assessed by cardiac CT, could influence the success rate of first-pass isolation (PVI). In single-center, prospective study, we enrolled consecutive symptomatic, drug-refractory AF who underwent initial radiofrequency catheter using modified CLOSE protocol....
Introduction Pulmonary vein isolation is the cornerstone of rhythm-control therapy for atrial fibrillation (AF). The very high-power, short-duration (vHPSD) radiofrequency (RF) ablation a novel technology that favors resistive heating while decreasing role conductive heating. Our study aimed to evaluate correlations between contact force (CF), power, impedance drop (ID), and temperature; assess their in lesion formation with vHPSD technique. Methods Consecutive patients who underwent initial...
OBJECTIVE Diabetes increases the risk of all-cause mortality and sudden cardiac death (SCD). The exact mechanisms leading to in diabetes are not well known. We compared incidence appropriate shocks patients with versus without a prophylactic implantable cardioverter defibrillator (ICD) included retrospective EU-CERT-ICD registry. RESEARCH DESIGN AND METHODS RESULTS A total 3,535 from 12 European centers mean age 63.7 ± 11.2 years (82% males) at time ICD implantation were analysis. 995 (28%)...
Background: Atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) is predominantly attributed to reconnection (PVR). Predictors of AF have been widely studied; however, data are scarce on procedural parameters that predict chronic PVR. We aimed study PVR rates and predictors Methods: retrospectively included 100 patients who underwent repeated ablation due initial PVI with the CARTO system. was determined during procedure by electrophysiological evaluation, characteristics...
Background and Aims . Resynchronization therapy (CRT) improves mortality induces reverse remodeling in heart failure (HF) patients with reduced ejection fraction wide QRS. Nonetheless, some do not improve despite the optimal medical right indications for device implantation. Therefore, finding biomarkers suitable identification of those is crucial. Vitamin D plays a classic hormonal role regulation bone metabolism also has physiological functions range nonskeletal tissues. Based on recent...
Objectives . Increases in red blood cell distribution width (RDW) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) predict the mortality of chronic heart failure patients undergoing cardiac resynchronization therapy (CRT). It was hypothesized that RDW is independent possibly even superior to from aspect long-term prediction. Design The counts serum levels 134 CRT were measured. Multivariable Cox regression models applied reclassification analyses performed. Results After separate...
There are previous studies on quality of life (QoL) in cardiac resynchronization therapy (CRT) patients; however, there no data with the short EuroQol-five dimensions (EQ-5D) questionnaire predicting outcomes.We aimed to assess predictive role baseline QoL and change at 6 months after CRT EQ-5D 5-year mortality response.........
Abstract Aim The association of standard 12-lead electrocardiogram (ECG) markers with benefits the primary prophylactic implantable cardioverter-defibrillator (ICD) has not been determined in contemporary era. We analysed traditional and novel ECG variables a large prospective, controlled ICD population to assess predictive value terms benefit. Methods results Electrocardiograms from 1477 patients 700 control (EU-CERT-ICD; non-randomized, controlled, prospective multicentre study;...
Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time a consequence of CRT. The aim this prospective study was overview these possible changes.A total 20 routine laboratory parameters were measured...
Purpose Our purpose was to compare the procedural characteristics, success rate, and complication rate of conventional fluoroscopic (CF) zero-fluoroscopic (ZF) approach in patients undergoing catheter ablation AVNRT or typical atrial flutter (Aflu). Methods 186 consecutive with an indication for Aflu were enrolled. Based on operator's preference, assigned either CF ZF group. In group EnSite NavX, Carto3, Rhythmia EAMS used guidance. Results The median age 56 (IQR = 42−68) years, 144 had...