A5002033439- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Alcoholism and Thiamine Deficiency
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Viral Infections and Immunology Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- Biochemical Acid Research Studies
- Mechanical Circulatory Support Devices
- Advanced X-ray and CT Imaging
- Biochemical and Molecular Research
- Amino Acid Enzymes and Metabolism
- Prion Diseases and Protein Misfolding
- Advanced Neural Network Applications
- Vitamin K Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Additive Manufacturing Materials and Processes
- Synthesis of Indole Derivatives
- Bone fractures and treatments
- Neurological and metabolic disorders
Semmelweis University
2017-2024
United Heart and Vascular Clinic
2022
Yale University
1962-1983
Kyoto University
1983
A diagnostic test for urinary inhibition of thiamine pyrophosphate-adenosine triphosphate phosphoryl transferase uncovered five definite and three probable cases subacute necrotizing encephalomyelopathy in a period one year, suggesting that the disease is not as rare originally believed. In addition, distribution phosphates sample brain from another patient who died was examined. As previous study, present brain, contrast to four control samples. This result substantiates our contention...
High-power short-duration (HPSD) radiofrequency ablation has been proposed to produce rapid and effective lesions for pulmonary vein isolation (PVI). We aimed evaluate the procedural characteristics first-pass (FPI) rate of HPSD very high-power (vHPSD) compared low-power long-duration (LPLD) technique. One hundred fifty-six patients with atrial fibrillation (AF) were enrolled assigned LPLD, HPSD, or vHPSD PVI. The energy setting was 30, 50, 90 W in groups, respectively. In group, W/4 s...
An enzyme system catalyzing the synthesis of thiamin triphosphate consists an (protein-bound diphosphate:ATP phosphoryltransferase), diphosphate bound to a macromolecule as substrate, ATP, Mg2+, and low molecular weight cofactor.This was established by combining purified essentially pure, macromoleculebound substrate prepared from rat livers.This found be protein, transphosphorylation with ATP shown occur on this which binds diphosphate.Free thiamin, monophosphate, diphosphate, have no...
In an attempt to evaluate the diagnostic potential of urine test for phosphoryltransferase inhibition in subacute necrotizing encephalomyelopathy (Leigh9s disease), has been performed on 511 individuals. Of these, 137 are known not have disease. The rate false positives controls 6.4 percent. More than a third 39 parents affected children had positive (inhibitory) urines (p < 0.001). All 16 patients with proved Leigh9s disease whose was tested within two weeks collection 0.0001). These...
Introduction Our pilot study aimed to evaluate the role of local impedance drop in lesion formation during pulmonary vein isolation with a novel contact force sensing ablation catheter that records as well and find cut-off value predicts successful formation. Materials methods After completing point-by-point radiofrequency isolation, success applications was evaluated by pacing along line at 10 mA, 2 ms pulse width. Lesions were considered if loss capture achieved. Results Out 645...
Nowadays, a novel contact-force guided ablation technique is used for enclosing pulmonary veins in patients with atrial fibrillation (AF). We sought to determine whether left (LA) wall thickness (LAWT) and vein (PV) dimensions, as assessed by cardiac CT, could influence the success rate of first-pass isolation (PVI). In single-center, prospective study, we enrolled consecutive symptomatic, drug-refractory AF who underwent initial radiofrequency catheter using modified CLOSE protocol....
Introduction Pulmonary vein isolation is the cornerstone of rhythm-control therapy for atrial fibrillation (AF). The very high-power, short-duration (vHPSD) radiofrequency (RF) ablation a novel technology that favors resistive heating while decreasing role conductive heating. Our study aimed to evaluate correlations between contact force (CF), power, impedance drop (ID), and temperature; assess their in lesion formation with vHPSD technique. Methods Consecutive patients who underwent initial...
Purpose Our purpose was to compare the procedural characteristics, success rate, and complication rate of conventional fluoroscopic (CF) zero-fluoroscopic (ZF) approach in patients undergoing catheter ablation AVNRT or typical atrial flutter (Aflu). Methods 186 consecutive with an indication for Aflu were enrolled. Based on operator's preference, assigned either CF ZF group. In group EnSite NavX, Carto3, Rhythmia EAMS used guidance. Results The median age 56 (IQR = 42−68) years, 144 had...
Aims We aimed to establish sex-specific predictors for 1-year VT recurrence and all-cause mortality in patients with structural heart disease undergoing catheter ablation. Methods analyzed data of 299 recorded our structured registry. These included medical history, echocardiography parameters, laboratory results, properties, procedural data. Results Out the patients, 34 (11%) were female. No significant difference was found between women men terms ( p = 0.74) or 0.07). In females, severe...
Background: Safety, efficacy, and patient comfort are the expectations during pulmonary vein isolation (PVI). We aimed to validate combined advantages of pre- periprocedural anticoagulation with non-vitamin K anticoagulants (NOACs) rigorous left atrial appendage thrombus (LAAT) exclusion computed tomography (CT). Methods: This study included a population consecutive patients, between March 2018 June 2020, who underwent cardiac CT within 24 h before PVI guide ablation rule out LAAT. NOAC was...
Abstract Background Ventricular tachycardia (VT) in ischemic heart disease (IHD) is the leading cause of sudden cardiac death (SCD). Despite well-defined recommendations, tailoring therapies individually often a challenge owing to great heterogeneity this population. We hypothesized that unsupervised machine learning can uncover hidden patterns identify patient subgroups with similar characteristics. Aims To use methods on database patients VT, discover characteristics and compare survival...
The predictive role of local impedance (LI) drop in lesion formation using a novel contact force sensing ablation catheter was recently described. purpose our current study to assess the temporal characteristics LI during and its correlation with acute efficacy.
Ventricular tachycardia (VT) recurrence after catheter ablation remains a concern, emphasizing the need for precise risk assessment. We aimed to use machine learning (ML) predict 1-month and 1-year VT following ablation.For 337 patients undergoing ablation, we collected 31 parameters including medical history, echocardiography, procedural data. 17 relevant features were included in ML-based feature selection, which yielded six five optimal recurrence, respectively. trained several supervised...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): -Project no. NVKP_16-1–2016-0017 (’National Heart Program’) has been implemented with the support provided by Ministry Innovation and Technology Hungary from Research, Development Fund Hungary, financed under NVKP_16 scheme. MEC_R-141548 Fund, MEC_R_21 Background Catheter ablation constitutes an established therapeutic option in patients monomorphic ventricular tachycardia (VT)....
Abstract Introduction High-power short-duration (HPSD) radiofrequency ablation has been proposed as a method for producing rapid and effective lesions pulmonary vein isolation (PVI). We aimed to evaluate the procedural characteristics first-pass (FPI) rate of HPSD very high-power (vHPSD) compared low-power long-duration (LPLD) technique. Methods 156 patients with atrial fibrillation (AF) were enrolled assigned LPLD, HPSD, or vHPSD PVI. The energy setting was 30W, 50W, 90W in groups,...
Több klinikai vizsgálat is bizonyította a technika biztonságosságát és hatásosságát.is created by resistive and conductive heating of the tissue.The ablation catheters generators have undergone technique.
Abstract Purpose: Safety, efficacy, and patient comfort are the primary expectations during pulmonary vein isolation (PVI). We aimed to validate combined advantages of pre-and periprocedural anticoagulation with non-vitamin K anticoagulants (NOACs) rigorous left atrial appendage thrombus (LAAT) exclusion computed tomography (CT). Moreover, we assessed effect workups catheter ablation on patients' quality life. Methods : Consecutive population was collected between March 2018 June 2020, who...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Project no. NVKP_16-1–2016-0017 (’National Heart Program’) - Research, Development and Innovation Fund Hungary Thematic Excellence Programme (2020-4.1.1.-TKP2020) the Ministry for Technology in Background Ventricular tachycardia (VT) is a life-threatening condition. Catheter ablation treatment often successful, however post procedural VT recurrence still remains an issue....
Abstract Funding Acknowledgements Type of funding sources: None. Background Atrial fibrillation (AF) and heart failure (HF) often coexist leading to worse outcomes compared AF or HF alone. According the current guidelines, PVI as first-line therapy should be considered, however, optimal timing procedure is still unknown. Purpose We aimed investigate effect early on all-cause mortality recurrence in patients with HFrEF. Methods analyzed data 162 symptomatic paroxysmal persistent LVEF &lt;...
Bevezetés: Elektrofi ziológiai vizsgálat és katéterabláció során a fl uoroszkóp használata katéterek valós időben való ábrázolásához szükséges lehet.Az ionizáló sugárzás sztochasztikus módon is okozhat egészségkárosodást, ilyenkor