A5065123417- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Vagus Nerve Stimulation Research
- Cardiac Imaging and Diagnostics
- Heart rate and cardiovascular health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Ion channel regulation and function
- Cardiac Valve Diseases and Treatments
- EEG and Brain-Computer Interfaces
- ECG Monitoring and Analysis
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Medication Adherence and Compliance
- Cardiac and Coronary Surgery Techniques
- Biomarkers in Disease Mechanisms
- Mechanical Circulatory Support Devices
- Cardiovascular and exercise physiology
University Medical Center Utrecht
2014-2025
Utrecht University
2022-2023
Heidelberg University
2015-2020
University Hospital Heidelberg
2015-2020
Netherlands Heart Institute
2018-2019
Tilburg University
2018
University Medical Center Groningen
1999-2006
University of Groningen
1998-2004
Leiden University
2002
AimThe neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-controlled trial designed to evaluate whether single dose of vagal nerve stimulation (VNS) would attenuate remodelling, improve function and increase exercise capacity in symptomatic patients with severe left ventricular (LV) systolic dysfunction despite guideline recommended medical therapy.
Background —Sustained shortening of the atrial effective refractory period (AERP), probably due to reduction in L-type calcium current, is a major factor initiation and maintenance fibrillation (AF). We investigated underlying molecular changes by studying relation between gene expression channel potassium channels AERP patients with AF. Methods Results —mRNA protein were determined left right appendages paroxysmal (n=13) or persistent (n=16) AF 13 controls sinus rhythm using reverse...
The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed assess current clinical effectiveness primary prevention ICD therapy.We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated (DCM) guideline indications for prophylactic implantation. endpoint all-cause...
To determine the impact of paroxysmal atrial fibrillation on quality life and to predictors life, particularly role symptomatology autonomic function.The study group comprised 73 patients with (mean age 54.1 years, 51 males). On average, had a 3-year history one paroxysm per week lasting 2 h. Quality was assessed using SF-36 (Medical Outcomes Study Short-Form Health Survey) compared age-matched controls. Autonomic function Holter monitoring analysis heart rate variability tests. Symptoms...
Therapy with an implantable cardioverter defibrillator (ICD) is established for the prevention of sudden cardiac death (SCD) in high risk patients. We aimed to determine effectiveness primary ICD therapy by analysing registry data from 14 centres 11 European countries compiled between 2002 and 2014, emphasis on outcomes women who have been underrepresented all trials.Retrospective local registries implantations 2014 were a central database. Predefined outcome measures overall mortality first...
Abstract Aims This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock mortality identify subgroups with insufficient benefit from ICD implantation. Methods results We recruited patients scheduled primary prevention implantation reduced left ventricular function. Bootstrapping-based Cox proportional hazards Fine Gray competing risk likely candidate predictors were developed all-cause shock, respectively....
Based on multiple large clinical trials conducted over the last decades guidelines for implantable cardioverter-defibrillator (ICD) implantations have been evolving. The increase in primary prophylactic ICD challenges us to be critical towards indications certain patient populations.We retrospectively collected characteristics and rates of appropriate inappropriate therapy, shock mortality all patients who received an University Medical Center Utrecht (UMCU) years 2006-2011.A total 1075 were...
Previous reports suggest that biventricular pacing (BiVp) fused with intrinsic conduction (BiVp-fusion, triple wavefront fusion) is associated improved resynchronization compared to pure-BiVp in cardiac therapy (CRT). This study aimed assess the association between acute hemodynamic benefit of CRT and signs BiVp-fusion by using a novel electrogram (EGM)-based method.In 17 patients undergoing implantation, 28 combinations atrioventricular (AV) interventricular (VV) delays were applied while...
Background and objectiveWe prospectively investigated combinations of risk stratifiers including multiple EP diagnostics in a cohort study ICD patients.MethodsFor 672 enrolled patients, we collected history, LVEF, T-wave alternans testing, 24-h Holter, NT-proBNP, the eGFR. All-cause mortality first appropriate shock were predefined endpoints.ResultsThe 635 patients included final analyses 63 ± 13 years old, 81% male, LVEF averaged 40 14%, 20% inducible at study, 63% had primary prophylactic...
Mini‐Maze and Mitral Valve Surgery. Introduction : After mitral valve (MV) surgery, preoperative atrial fibrillation (AF) often recurs while cardioversion therapy generally fails. Additional Cox maze surgery improves postoperative arrhythmia outcome, but the extensive nature of such an approach limits general appliance. We investigated clinical outcome a simplified, less procedure (“mini‐maze”) as adjunct to MV surgery. Methods Results Thirteen patients with disease AF were treated combined...
This study was performed to evaluate the feasibility of intra-procedural visualization optimal pacing sites and image-guided left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT). In fifteen patients (10 males, 68 ± 11 years, 7 with ischemic cardiomyopathy ejection fraction 26 5%), were identified pre-procedurally using imaging. Cardiac magnetic resonance (CMR) derived scar dyssynchrony maps created for all patients. six anatomy phrenic nerve (LPN) coronary sinus...
Background One third of primary prevention implantable cardioverter-defibrillator patients receive appropriate therapy, but all remain at risk defibrillator complications. Information on these complications in contemporary cohorts is limited. This study assessed and their factors after implantation a Dutch nationwide prospective registry cohort forecasts the potential reduction under distinct scenarios updated indication criteria. Methods Results Complications multicenter 1442 implant were...
The EUTrigTreat clinical study has been designed as a prospective multicentre observational and aims to (i) risk stratify patients with an implantable cardioverter defibrillator (ICD) for mortality shock using multiple novel established markers, (ii) explore link between repolarization biomarkers genetics of ion (Ca2+, Na+, K+) metabolism, (iii) compare the results invasive non-invasive electrophysiological (EP) testing, (iv) assess changes stratification tests over time, (v) associate...
Abstract Aims The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. EUropean Comparative Effectiveness Research to Assess the Use Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims assess its current value. Methods and results EU‐CERT‐ICD a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries....