A5017124369- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Electrochemical Analysis and Applications
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
University Medical Center Utrecht
2016-2025
Utrecht University
2023
University Hospital of Basel
2020
University of Basel
2020
Population Health Research Institute
2020
McMaster University
2020
University Hospital Heidelberg
2019
Heidelberg University
2019
St. Antonius Ziekenhuis
2014
The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed assess current clinical effectiveness primary prevention ICD therapy.We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated (DCM) guideline indications for prophylactic implantation. endpoint all-cause...
Abstract Background Implantable cardioverter-defibrillators (ICDs) have been proven to reduce the risk of sudden cardiac death from ventricular tachyarrhythmias. However, ICDs can sometimes induce malignant arrhythmias. We describe a case fibrillation triggered by an automatic atrial threshold search. Case presentation A 72-year-old man presented after syncopal episode. His medical history included moderate aortic regurgitation and symptomatic second-degree AV block, for which he received...
Abstract Aims Fragmented QRS complex with visible notching on standard 12-lead electrocardiogram (ECG) is understood to represent depolarization abnormalities and signify risk of cardiac events. Depolarization similar prognostic implications likely exist beyond visual recognition but no technology presently suitable for quantification such invisible ECG abnormalities. We present a technology. Methods results A signal processing method projects all leads the into optimized three perpendicular...
Background and objectiveWe prospectively investigated combinations of risk stratifiers including multiple EP diagnostics in a cohort study ICD patients.MethodsFor 672 enrolled patients, we collected history, LVEF, T-wave alternans testing, 24-h Holter, NT-proBNP, the eGFR. All-cause mortality first appropriate shock were predefined endpoints.ResultsThe 635 patients included final analyses 63 ± 13 years old, 81% male, LVEF averaged 40 14%, 20% inducible at study, 63% had primary prophylactic...
Kv 11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 a negative allosteric modulator/activator channels that inhibits early afterdepolarizations in vitro. We tested for antiarrhythmic efficacy potential proarrhythmia dog model.LUF7244 was vitro (a) increasing human IKv11.1 canine IKr (b) decreasing dofetilide-induced action lengthening cardiomyocytes derived from induced pluripotent stem cells isolated...
Background Short-term variability of the QT interval (STVQT) has been proposed as a novel electrophysiological marker for prediction imminent ventricular arrhythmias in animal models. Our aim is to study whether STVQT can predict patients. Methods and Results In 2331 patients with primary prophylactic implantable cardioverter defibrillators, 24-hour ECG Holter recordings were obtained part EU-CERT-ICD (European Comparative Effectiveness Research Assess Use Primary Prophylactic Implantable...
Post-extrasystolic potentiation (PESP) describes the phenomenon of increased contractility beat following an extrasystole and has been attributed to changes in Ca 2+ homeostasis. While this effect long regarded be a normal physiological phenomenon, number reports describe enhanced post-extrasystolic heart failure patients. The exact mechanism PESP is unknown, but disruption handling may underlying cause. use as prognostic marker or therapeutic intervention have recently regained new...
Introduction In the chronic AV-block (CAVB) dog model, structural, contractile and electrical remodeling occur, which predispose heart to dofetilide-induced Torsade de Pointes (TdP) arrhythmias. Previous studies found a relation between inducibility of TdP, while structural is not prerequisite for arrhythmogenesis. this study, we prospectively assessed in vivo markers TdP inducibility. Methods 18 anesthetized dogs, maximal first derivative left ventricular pressure (LV dP/dtmax) was at acute...
Objective Short-term variability of the QT-interval (STV-QT) was shown to be associated with an increased risk ventricular arrhythmias. We aimed at investigating (a) whether STV-QT exhibits circadian pattern, and (b) such pattern differs between patients high low arrhythmia risk. Methods As part ongoing EU-CERT-ICD study, 24h resolution digital ambulatory 12-lead Holter recordings are collected prior ICD implantation for primary prophylactic indication. Presently available were categorized...
In addition to beat-to-beat fluctuations, action potential duration (APD) oscillates at (1) a respiratory frequency and (2) low (LF) (<0.1 Hz), probably caused by bursts of sympathetic nervous system discharge. This study investigates whether ventricular remodeling in the chronic AV block (CAVB) dog alters these oscillations APD this has consequences for arrhythmogenesis. We performed retrospective analysis 39 experiments sinus rhythm (SR), acute (AAVB), after 2 weeks block. Spectral left...
Objective To test the hypothesis that in recipients of primary prophylactic implantable cardioverter-defibrillators (ICDs), non-planarity ECG vector loops predicts (a) deaths despite ICD protection and (b) appropriate shocks. Methods Digital pre-implant ECGs were collected 1948 recipients: 21.4% females, median age 65 years, 61.5% ischaemic heart disease (IHD). QRS T wave three-dimensional constructed using singular value decomposition allowed to measure loop planarity. The non-planarity,...
Abstract Background Third-degree atrioventricular (AV) block can result in sudden cardiac death if no reliable escape rhythm is present. Here, we report a case of an 86-year-old female patient who developed third-degree AV leading to arrest. Surprisingly, sinus returned after 4 min asystole, and she showed complete neurological recovery. Case summary Emergency services were contacted by the husband woman was found unconscious. Ambulance personnel diagnosed without transcutaneous pacing...
Background: Short-term variability (STV) of repolarization the monophasic action potential duration (MAPD) or activation recovery interval (ARI) on intracardiac electrogram (EGM) increases abruptly prior to occurrence ventricular arrhythmias in chronic AV-block (CAVB) dog model. Therefore, this parameter might be suitable for continuous monitoring imminent using EGM stored an implanted device. However, 24/7 would require automatic STVARI measurement by Objective: To evaluate a newly...
This data article features supplementary figures and tables related to the "Differential Multivariable risk prediction of appropriate shock vs. competing mortality – a prospective cohort study estimate benefits from implantable cardioverter defibrillator therapy" (Bergau et al., 2018) [1]. The show clinical CONSORT graph (data that number patients not-analyzable as well distribution by outcomes) correlation scatter plot for scores calculated score values two plotted against each other)....
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): European Community’s 7th Framework Programme (HEALTH-F2-2009-602299) Ministry Health, Czech Republic Background Three-dimensional (e.g., vectorcardiography) loops normal physiologic QRS complex and T wave are known to be planar. Non-planarity these electrocardiogram (ECG) was described in cardiac patients, mainly relation ischemic heart disease, but predictive values the extent...
Introduction: Short-term variability of repolarization (STV) increases prior to ventricular arrhythmias (VA) both in humans and animal models VA, is therefore a promising tool for real-time monitoring arrhythmic risk. To integrate this concept cardiac devices, method automatically determine STV on intracardiac electrograms (EGM) was developed. This algorithm demonstrated high efficacy predicting life-threatening VA studies, but still needs be evaluated human signals. Objective: assess the...
the chronic AV-block dog model
Methods: In our single centre study 109 consecutive patients were retrospectively analysed.Quality of life has been assessed by a standardized questionnaire (EQ-5D-3L, modified).Additionally, clinical baseline and follow up data recorded arrhythmic episodes evaluated.Results: Mean WCD therapy time was 56.2 (6 42.4) days, with daily wear 19.7 5) hours.A total 3441 arrhythmia detected.Of these, 27 (1%) adequate, but did not require shock therapy.Likewise, no inadequate occurred.WCD negatively...