A5069286069- Aortic aneurysm repair treatments
- Intracranial Aneurysms: Treatment and Complications
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Elasticity and Material Modeling
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Infectious Aortic and Vascular Conditions
- Hemodynamic Monitoring and Therapy
- Medical Imaging Techniques and Applications
- Connective tissue disorders research
- Lung Cancer Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Medical Image Segmentation Techniques
- Mechanical Circulatory Support Devices
- Abdominal Surgery and Complications
- Cardiovascular Function and Risk Factors
- Intracerebral and Subarachnoid Hemorrhage Research
- Automotive and Human Injury Biomechanics
- Computer Graphics and Visualization Techniques
- Antibiotics Pharmacokinetics and Efficacy
University of Iowa
2016-2025
Engineering Arts (United States)
2014-2022
Mayo Clinic
2017
Rush University Medical Center
2017
Mount Sinai Medical Center
2017
Wake Forest University
2017
University of Pittsburgh
1996-2006
Weatherford College
2005
Dartmouth–Hitchcock Medical Center
2002
Pittsburg State University
1995
Object. The authors investigated whether quantified shape or size indices could better discriminate between ruptured and unruptured aneurysms. Methods. Several custom algorithms were created to quantifiy the of intracranial aneurysms by using three-dimensional computerized tomography angiography models brain vasculature. Data from 27 patients with evaluated in a blinded fashion determine aneurysm discriminated groups. Five eight calculated for each aneurysm. Two-tailed independent Student...
There are conflicting data between natural history studies suggesting a very low risk of rupture for small, unruptured intracranial aneurysms and retrospective that have identified much higher frequency ruptured than expected.To use the prospective International Study Unruptured Intracranial Aneurysms cohort to identify morphological characteristics predictive aneurysm rupture.A case-control design was used analyze associated with in database. Fifty-seven patients during follow-up were...
Background It is unclear what morphological features of brain aneurysms are better at predicting risk rupture. We conducted a meta‐analysis to analyze the best determinants rupture status. Methods The Nested Knowledge platform was used perform search articles reporting on aneurysm size, aspect ratio (AR), size (SR), ellipticity index, nonsphericity and undulation index. mean differences between ruptured unruptured were calculate effect sizes. Results A total 63 studies with 13 025 included:...
Abstract Interlobar sliding has long been suspected to help the lungs adapt changes in thoracic cavity shape by reducing parenchymal distortion. Our previous controlled computational experiment tested hypothesis that lung lobar reduces distortion during breathing, but only left was studied. The goal of this study extend analysis right which three lobes and two fissures compared lung?s single fissure. Finite elastic contact mechanics models were used perform paired subject-specific...
Abstract The paper presents a computational method for predicting the initial geometry of finitely deforming anisotropic elastic body from given deformed state. is imperative class problem in stress analysis, particularly biomechanical applications. While basic idea has been established elsewhere Comput. Methods Appl. Mech. Eng. 1996; 136 :47–57; Int. J. Numer. Meth. Engng 1998; 43 : 821–838), implementation general solids not trivial exercise, but comes after systematic development Eulerian...
Coil compaction is thought to be the main mechanism for recurrence in cerebral aneurysms with previously successful coil embolization. We hypothesize that sac growth may equally or more important. The objective was study relative roles of and as explanations aneurysm requiring retreatment a population using quantitative 3D image processing methods.From July 2009 December 2010, 175 were coiled at University Iowa hospitals clinics. Eight had major (4.4-12.1 months between procedures; mean: 7.2...
The development of intimal hyperplasia is the major cause failure both autologous saphenous vein and synthetic coronary artery bypass grafts. This partially due to graft-host vessel compliance mismatch. Cellulose chitosan (CELL:CHIT) are biocompatible, nontoxic, naturally occurring biopolymers that have been used extensively for biomedical applications. Elastic properties membranes made CELL:CHIT blends with different ratios between each polymer were determined using uniaxial tests ratio...
OBJECT The goal of this prospective longitudinal study was to test whether image-derived metrics can differentiate unruptured aneurysms that will become unstable (grow and/or rupture) from those remain stable. METHODS One hundred seventy-eight patients harboring 198 cerebral for whom clinical observation and follow-up with imaging surveillance recommended at 4 centers were prospectively recruited into study. Imaging data (predominantly CT angiography) initial presentation recorded....
Sentinel headaches (SHs) associated with cerebral aneurysms (CAs) could be due to microbleeds, which are considered a sign that an aneurysm is unstable. Despite the prognostic importance of these they remain difficult detect using routine imaging studies. The objective this pilot study microbleeds SH magnetic resonance (MRI) quantitative susceptibility mapping (QSM) sequence and then evaluate morphological characteristics unstable microbleeds.
Background Intracranial fusiform aneurysms are complex and poorly characterized vascular lesions. High-resolution magnetic resonance imaging (HR-MRI) computational morphological analysis may be used to characterize cerebral aneurysms. Objective To use advanced understand the unique pathophysiology, determine possible underlying mechanisms of instability Methods Patients with unruptured intracranial prospectively underwent 3T HR-MRI at diagnosis. Aneurysmal wall enhancement was objectively...
Abstract Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified in 3D imaging using semi-automated method. Thirty patients with 33 unruptured aneurysms prospectively underwent high-resolution 7T-MRI. The signal intensity (SI) aneurysm was mapped and normalized to pituitary stalk (PS) corpus callosum (CC). CC proved be more...