A5041222881- Gallbladder and Bile Duct Disorders
- Nutrition and Health in Aging
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Kidney Stones and Urolithiasis Treatments
- Esophageal and GI Pathology
- Pediatric Urology and Nephrology Studies
- Gastrointestinal disorders and treatments
- Airway Management and Intubation Techniques
- Surgical Simulation and Training
- Gastric Cancer Management and Outcomes
- Pleural and Pulmonary Diseases
- Pancreatitis Pathology and Treatment
- Tracheal and airway disorders
- Aortic aneurysm repair treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and Vascular Pathologies
- Intestinal Malrotation and Obstruction Disorders
- Anatomy and Medical Technology
- Gut microbiota and health
- Biliary and Gastrointestinal Fistulas
- Adipose Tissue and Metabolism
- Pneumothorax, Barotrauma, Emphysema
- Diet and metabolism studies
Universidade de São Paulo
2016-2025
Hospital Universitário da Universidade de São Paulo
2015-2025
Universidade Brasil
2009-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2025
Natura (Brazil)
2024-2025
Sociedade Brasileira de Cirurgia Plástica
2023
National Cancer Institute
2023
Center for Cancer Research
2023
Hospital Sírio-Libanês
2016-2020
Santa Casa Hospital
2017
Multidrug resistant microorganisms are a growing challenge and new substances that can be useful to treat infections due these needed. Silver nanoparticle may future option for treatment of infections, however, the methods described in vitro evaluate inhibitory effect controversial. This study evaluated activity silver nanoparticles against 36 susceptible 54 multidrug Gram-positive Gram-negative bacteria from clinical sources. The were oxacilin-resistant Staphylococcus aureus,...
Background: Endoscopic retrograde cholangiopancreatography may fail because of malignant involvement the second portion duodenum and major papilla. Alternatives include percutaneous transhepatic biliary drainage (PTBD) or surgical bypass. ultrasonography-guided choledochoduodenostomy (EUS-CD) has been reported as an alternative. Objective: To prospectively compare EUS-CD PTBD in patients with unresectable obstruction. Design: Prospective randomized study. Setting: Tertiary center. Main...
OBJECTIVE The authors sought to construct, implement, and evaluate an interactive stereoscopic resource for teaching neuroanatomy, accessible from personal computers. METHODS Forty fresh brains (80 hemispheres) were dissected. Images of areas interest captured using a manual turntable processed stored in 5337-image database. Pedagogic evaluation was performed 84 graduate medical students, divided into 3 groups: 1 (conventional method), 2 (interactive nonstereoscopic), stereoscopic). method...
Cachexia, a paraneoplastic syndrome markedly associated with worsened prognosis in cancer patients, provokes profound wasting of both lean and adipose mass an association state metabolic "chaos". The white tissue responds to cachexia marked local inflammation may be thus relevant contributor systemic inflammation. To address this hypothesis we examined the correlation between expression adipokines plasma concentration cachectic stable weight patients or without cancer. Adiponectin...
Background and aims Cachexia is a syndrome characterized by marked involuntary loss of body weight. Recently, adipose tissue (AT) wasting has been shown to occur before the appearance other classical cachexia markers. We investigated composition rearrangement extracellular matrix, adipocyte morphology inflammation in subcutaneous AT (scAT) pad gastrointestinal cancer patients. Methods Surgical biopsies for scAT were obtained from patients, who signed up into following groups: (CC, n = 11),...
Cachexia affects about 80 percent of gastrointestinal cancer patients. This multifactorial syndrome resulting in involuntary and continuous weight loss is accompanied by systemic inflammation immune cell infiltration various tissues. Understanding the interactions between tumor, cells peripheral tissues could help attenuating inflammation. Therefore, we investigated subcutaneous adipose tissue stable cachectic patients with same diagnosis, order to establish correlations tumor...
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which related with poor prognosis compromised quality life. Dysfunctional mitochondria are associated lower strength atrophy in cancer patients, yet poorly described human cachexia. We herein investigated mitochondrial morphology, autophagy apoptosis patients gastrointestinal cancer-associated cachexia (CC), as compared weight-stable group...
Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) one the key characteristics cachexia. WAT wasting paralleled by microarchitectural remodeling in cachectic cancer patients. Fibrosis results from uncontrolled ECM synthesis, process which, transforming growth factor-beta (TGFβ) plays pivotal role. So far, mechanisms involved (AT) re-arrangement, and role TGFβ inducing AT weight-losing patients are poorly understood. This...
It is known that obesity has a multifactorial etiology involves genetic and environmental factors. The WHO estimates the worldwide prevalence of 1.9 billion overweight adults more than 650 million people with obesity. These alarming data highlight high growing represent risk factor for development aggravation other chronic diseases, such as nonalcoholic fatty liver disease (NAFLD) frequently considered hepatic outcome type 2 diabetes. use non-pharmacological therapies food supplements,...
Abstract Overweight and obesity are closely linked to gut dysbiosis/dysmetabolism disrupted De‐Ritis ratio [aspartate aminotransferase (AST)/alanine (ALT) ratio], which may contribute chronic noncommunicable diseases onset. Concurrently, extensive research explores nutraceuticals, health‐enhancing supplements, for disease prevention or treatment. Thus, sedentary overweight volunteers were double‐blind randomized into two groups: Novel Nutraceutical_(S) (without silymarin) Nutraceutical (with...
Abstract Background Cachexia is a multifactorial and multiorgan syndrome associated with cancer other chronic diseases characterized by severe involuntary body weight loss, disrupted metabolism, inflammation, anorexia, fatigue, diminished quality of life. This affects around 50% patients colon directly responsible for the death at least 20% all patients. Systemic inflammation has been recently proposed to underline most cachexia‐related symptoms. Nevertheless, exact mechanisms leading...
Cancer cachexia affects about 80% of advanced cancer patients, it is linked to poor prognosis and date, there no efficient treatment or cure. The syndrome leads progressive involuntary loss muscle fat mass induced by systemic inflammatory processes. role the white adipose tissue (WAT) in onset manifestation gained importance during last decade. WAT wasting not only characterized increased lipolysis release free fatty acids (FFA), but addition, owing its high capacity produce a variety...
Abstract Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well fibrosis. aim of the present study was characterise inflammatory circulating factors profile, potentially contributing fibrosis in cachectic cancer patients. Methods 74 patients (weight stable n = 31; 43) diagnosed colorectal were recruited, biopsies collected during surgery. Multiplex assay performed...
Abstract Background Cancer cachexia (CCx) is a multifactorial energy‐wasting syndrome reducing the efficiency of anti‐cancer therapies, quality life, and survival cancer patients. In past years, most studies focused on identification tumour host‐derived proteins contributing to CCx. However, there still lack addressing changes in bioactive lipids. The aim this study was identify specific lipid species as hallmark CCx by performing broad range analysis plasma from well‐established mouse...
Abstract Nutraceutical interventions supporting microbiota and eliciting clinical improvements in metabolic diseases have grown significantly. Chronic stress, gut dysbiosis, metainflammation emerged as key factors intertwined with sleep disorders, consequently exacerbating the decline quality of life. This study aimed to assess effects two nutraceutical formulations containing prebiotics (fructooligosaccharides (FOS), galactooligosaccharides (GOS), yeast β-glucans), minerals (Mg, Se, Zn),...
Abstract Globally, 537 million people suffer from diabetes mellitus (DM), a condition often associated with sensory disturbances, wound development, and chronic pain, which significantly affects the quality of life imposes substantial economic burden. This study evaluated effects photobiomodulation (PBM) therapy on nociceptive changes in diabetic patients to understand pain manifestations explore PBM's molecular mechanisms healing. Twenty type 2 DM underwent clinical assessments, completed...