A5050634053- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Tea Polyphenols and Effects
- Cancer, Hypoxia, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Food composition and properties
- Healthcare Regulation
- Inflammatory Biomarkers in Disease Prognosis
- Histone Deacetylase Inhibitors Research
- Polysaccharides Composition and Applications
- Reproductive Biology and Fertility
- Dietary Effects on Health
- Menopause: Health Impacts and Treatments
- Preterm Birth and Chorioamnionitis
- Fatty Acid Research and Health
- Healthcare during COVID-19 Pandemic
- Stress Responses and Cortisol
- Ovarian cancer diagnosis and treatment
Universidade do Porto
2024
Universidade Federal de São Paulo
2014-2023
Federal Institute of São Paulo
2018
Albert Einstein College of Medicine
2016
Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) one the key characteristics cachexia. WAT wasting paralleled by microarchitectural remodeling in cachectic cancer patients. Fibrosis results from uncontrolled ECM synthesis, process which, transforming growth factor-beta (TGFβ) plays pivotal role. So far, mechanisms involved (AT) re-arrangement, and role TGFβ inducing AT weight-losing patients are poorly understood. This...
Abstract Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well fibrosis. aim of the present study was characterise inflammatory circulating factors profile, potentially contributing fibrosis in cachectic cancer patients. Methods 74 patients (weight stable n = 31; 43) diagnosed colorectal were recruited, biopsies collected during surgery. Multiplex assay performed...
Background: Hypertrophic Cardiomyopathy (HCM) is a genetic disorder marked by left ventricular hypertrophy (LVH) without secondary causes. Diagnosis made through imaging techniques like echocardiography or MRI, with wall thickness ≥15 mm in adults indicating HCM. Thickness of 13-14 can suggest HCM individuals family history sudden cardiac death (SCD), which predict positive tests. However, routine testing not recommended for phenotype-negative relatives unless guided cardiovascular genetics...
O presente estudo revisou a cirurgia metabólica em pacientes com obesidade grau I e diabetes tipo 2, utilizando uma abordagem de revisão integrativa. objetivo foi analisar efetividade segurança da como alternativa terapêutica para indivíduos 2. A metodologia consistiu integrativa realizada nas bases dados Scientific Electronic Library Online (SCIELO), Cochrane Medline, descritores ciências saúde relacionados ao tema, “Bariatric Surgery”, “Obesity” “Diabetes Mellitus, Type 2”. Os resultados...
Abstract Background Cancer cachexia (CC) is a multifactorial syndrome, often irreversible, that affects patients with cancer influenced, in part, by the inflammatory condition. Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, growth factors; given possible crosstalk between peritumoural tumour, these may play an important role biology carcinogenesis. Methods The aim of this study was to evaluate factors produced cohort 16 colorectal either weight‐stable (WSC; n = 7)...
The rapid increase in the number of individuals with obesity, over past four decades, is triggered by a complex interactions among factors. Despite plethora treatments available, side effects are commonly observed and, this context, herbal medicines have been employed as an alternative form therapy. Ginkgo biloba extract (GbE) has described promising new pharmacological approach to treat obesity. In order better comprehend mechanisms involved potential effect, present study evaluated GbE...
Abstract This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic behavioral parameters, explore connection obesity depression after menopause. Wistar rats were either ovariectomized sham-operated fed with standard chow lard-enriched diet for twelve weeks. Sub-groups received replacement. Depressive-like behaviors assessed by forced swim test locomotor activity was elevated plus maze test. Ovariectomy alone increased...
Abstract Background Cachexia is a wasting syndrome associated with systemic inflammation and metabolic disruption. Detection of the early signs disease may contribute to effective attenuation symptoms. Despite playing central role in control metabolism inflammation, liver has received little attention cachexia. We previously described relevant disruption pathways organ an animal model cachexia, herein, we adopt same investigate temporal onset liver. The aim was thus study rodent...
Introduction Green tea extract has anti-inflammatory and antioxidant effects which improve dyslipidemia decrease adipose tissue depots associated with hyperlipidic diet consumption. Objective To evaluate the effect of green consumption by rats during pregnancy lactation on metabolism their offspring that received control or high-fat water 10 weeks after weaning. Methods Wistar (W) diluted in (G) (400 mg/kg body weight/day), (10 animals W G groups) lactation. After weaning, a (CW) (HW), for...
Obesity is mainly caused by intake of a high-fat diet and sedentarism, considered public health issue worldwide. Increased intestinal permeability may favour endotoxaemia generated lipopolysaccharides, substance present in the cell membrane Gram-negative bacteria, and, consequently, an increase systemic inflammation metabolic diseases. In contrast (On other hand), consumption healthy can help prevention treatment syndrome. this way, chia seeds (Salvia hispanica L.), rich polyunsaturated...
Obesity is a multifactorial disease with genesis including the ingestion of hypercaloric diet rich in fat, ultra-processed food, poor micronutrients and fiber. Some food bioactive compounds are studies to prove their capacity decrease deleterious metabolic effect promoted by refined sugar fat rich-diet. The goal this study was evaluate Juçara (Euterpe edulis Mart.) supplementation, fruit fiber compounds, mostly anthocyanin, on systemic inflammation obese mice. Swiss mice were treated...
The objective was to investigate the effects of maternal consumption green tea extract during pregnancy and lactation on mothers offspring metabolism. female Wistar rats, first day until end lactation, divided into groups: MC- received water ME- (400 mg/kg body weight/day), both ingested control diet. After at 28th post-partum, pups from each mother were euthanized composed FC- pup FE- extract. ME group increased IL-10/TNF-α ratio IL-1β content in mesenteric retroperitoneal adipose tissues,...
Contradictory results are reported for the role of angiopoietin-like 4 (ANGPTL-4) in development cancer-cachexia and inflammation, given its importance angiogenesis inflammatory signaling. Our aim was to analyze levels ANGPTL-4 colorectal cancer patients with a stable weight those cachexia order establish relationship between process.Plasma tumor were higher CC comparison other groups. A positive association verified plasmatic NFκB from CC. In WSC, we identified an ANGPTL-4, IL-15, IL-10...
Four‐week‐old female Wistar rats were divided into two groups and fed a control diet (C) or hyperlipidic (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) sham surgery (SHAM). They received C H the next four The body weight gain (BW), food efficiency (FE), carcass lipid content higher in OVX than SHAM H. exhibited serum leptin level other groups. IL‐6, TNF‐ α , IL‐10 of mesenteric (MES) adipose tissue was lower C. retroperitoneal (RET) showed decreased TG relative to Similar...
Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim this study was investigate the effects chitosan coacervate whey protein on proinflammatory processes mice fed high-fat diet.Mice were divided into two groups receiving either normolipidic or diet; animals each diet given supplement (gavage, 36 mg protein/kg body weight) tap water for four weeks [groups: plus (C); and (CC); (H); (HC)].The promoted...
Abstract Background Sex chromosome abnormalities associated with disorders of sexual development (DSD) are rarely described in cats, mainly due to the lack chromossome studies that precisely reveal condition. Genetic approaches therefore required order detect sex chromossomes as variations number and structure chromosomes, or presence a second cell line mosaicim chimerism. Case presentation A male Shorthair cryptorchid cat was presented clinical signs anorexia, tenesmus hyperthermia....
Chia seed (Salvia hispanica L.) contains high amounts of n-3 α-linolenic acid (ALA) and has been associated with many health benefits. The aim the present study was to evaluate AIN-93 diet supplemented by chia flour on cancer-cachexia development tissues inflammatory response. Wistar rats at 30 days old were treated control or for eight weeks. After this period, half animals in each group inoculated Walker 256 tumor cells. On 14th day after inoculation, euthanized white adipose tissue...
Lifestyle changes regarding diet composition and exercise training have been widely used as a non-pharmacological clinical strategy in the treatment of obesity, complex difficult-to-control disease. Taking potential browning process increasing thermogenesis into account, aim this paper was to evaluate effect resistance, aerobic, combination on markers white adipose tissue from rats with obesity who were switched balanced normal calorie intake. Different types groups promote reduction delta...
Objective The aim of this study was to evaluate the effect adding xanthan gum diet rats on production cytokines and pro-inflammatory factors tumor development in inoculated with Walker 256 cells. Methods Fifty-six were divided into 4 groups: control (C), (TC), (XG), (TXG). Results ingestion promotes changes cytokine content: increasing IL-6 TNF-α IL-10 retroperitoneal adipose tissue compared group; mesenteric C TXG groups. On contrary, addition did not affect tumors rats. Conclusion...
To assess if universal screening for cervical length (CL) had an impact on timing of antenatal corticosteroids (ACS). Retrospective cohort study from October 2012– August 2015 all non-anomalous singleton gestations with short CL identified routine anatomic ultrasound subsequent preterm birth (PTB) between 24–34 weeks gestational age (GA). Matched controls were spontaneous PTB at within the same delivery window who not as having a screening. ACS was based most recent course and optimal < =7...
OBJETIVO: Analisar os impactos da suplementação imunomoduladora em pacientes oncológicos eleitos à cirurgia do trato gastrointestinal por meio de uma revisão literatura.MÉTODOS: Revisão literatura, utilizando a base dados PUBMED e Biblioteca Virtual Saúde (BVS), com descritores: nutritional therapy, immunomodulation, surgery, neoplasms. A pergunta pesquisa foi: o que as publicações existentes apontam sobre efeitos nos gastrointestinal? Foram incluídos: artigos originais inglês, português ou...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)