A5017730093- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Fatty Acid Research and Health
- Birth, Development, and Health
- Exercise and Physiological Responses
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Antioxidant Activity and Oxidative Stress
- Nutritional Studies and Diet
- Eating Disorders and Behaviors
- Tea Polyphenols and Effects
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Health and Lifestyle Studies
- Ginkgo biloba and Cashew Applications
- Stress Responses and Cortisol
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Infant Nutrition and Health
Universidade Federal de São Paulo
2015-2024
University of Cambridge
2022-2024
Medical Research Council
2024
Wellcome/MRC Institute of Metabolic Science
2022-2024
Wellcome Trust
2022
Universidade Paulista
2021
Universidade São Francisco
2016
Universidade de São Paulo
2011-2016
Universidade Estadual de Campinas (UNICAMP)
2016
Universidade Federal de Minas Gerais
2015
The ingestion of excessive amounts saturated fatty acids (SFAs) and transfatty (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, obesity. focus this paper was elucidate the influence dietary SFA TFA intake on promotion lipotoxicity liver cardiovascular, endothelial, gut microbiota systems, as well resistance endoplasmic reticulum stress. favor proinflammatory state leading resistance. These can involved in several inflammatory pathways,...
Stroke is the most common cause of motor disabilities and a major mortality worldwide. Adult stem cells have been shown to be effective against neuronal degeneration through mechanisms that include both recovery neurotransmitter activity decrease in apoptosis oxidative stress. We chose lineage stroke-prone spontaneously hypertensive rat (SHRSP) as model for cell therapy. SHRSP rats can develop such severe hypertension they generally suffer stroke at approximately 1 year age. The aim this...
Supplementation with epigallocatechin-3-gallate has been determined to aid in the prevention of obesity. Decaffeinated green tea extract appears restore a normal hepatic metabolic profile and attenuate high-fat diet (HFD)-induced effects, thereby preventing non-alcoholic fatty liver disease mice. Mice were maintained on either control (CD) or HFD for 16 weeks supplemented water (50 mg/kg/day). The body mass increase, serum adiponectin level, lipid measured over course treatment. Furthermore,...
A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to development stimulating secretion inflammatory factors. study aimed examine plasma markers endotoxin levels in individuals with and/or highly trained subjects at rest. Methods: Fourteen male (sedentary n = 7; 7) were recruited. Blood samples...
To compare the effects of aerobic training (AT) with plus resistance (AT+RT) in nonalcoholic fatty liver disease (NAFLD) obese adolescents.Long-term interdisciplinary weight-loss therapy (1 year clinical, nutritional, psychological, and exercise-related intervention).Fifty-eight postpubertal adolescents were randomized to AT or AT+RT according NAFLD diagnosis. Adipokine neuropeptide concentrations measured by enzyme-linked immunosorbent assay, visceral fat ultrasound, body composition...
It is well known that high fat diets (HFDs) induce obesity and an increase in proinflammatory adipokines. Interleukin-6 (IL-6) considered the major inflammatory mediator obesity. Obesity associated with a vitamin deficiency, especially of vitamins E D3. We examined effects D3 supplementation on levels IL-6 IL-10 (as marker anti-inflammatory cytokines since, balance between pro- maintained) protein expression adipose tissue mice provided HFD. Additionally, we measured treatment LPS-stimulated...
Adiponectin and interleukin 10 (IL-10) are adipokines that predominantly secreted by differentiated adipocytes involved in energy homeostasis, insulin sensitivity, the anti-inflammatory response. These two reduced obese subjects, which favors increased activation of nuclear factor kappa B (NF-κB) leads to elevation pro-inflammatory adipokines. However, effects adiponectin IL-10 on NF-κB DNA binding activity (NF-κBp50 NF-κBp65) proteins with toll-like receptor (TLR-2 TLR-4) pathway, such as...
The aim of this study was to evaluate the effects green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue diet-induced obese mice. Animals were randomized into four groups: CW (chow diet water); CG water + extract); HW (high-fat HG extract). mice fed ad libitum with chow or high-fat concomitantly supplemented (oral gavage) 400 mg/kg body weight/day (CG HG, resp.). treatments performed for eight weeks. UPLC showed that 10 mg/mL extract,...
Abstract Background Adiponectin is the most abundant plasma protein synthesized for part in adipose tissue, and it an insulin-sensitive hormone, playing a central role glucose lipid metabolism. In addition, increases fatty acid oxidation muscle potentiates insulin inhibition of hepatic gluconeogenesis. Two adiponectin receptors have been identified: AdipoR1 major receptor expressed skeletal muscle, whereas AdipoR2 mainly liver. Consumption high levels dietary fat thought to be factor...
It has been suggested that access to high caloric food attenuates stress response. The present paper investigates whether commercial chow enriched with glucose and fat, here referred as comfort alters behavioral, metabolic, hormonal parameters of rats submitted three daily sessions foot-shock stress. Food intake, anxiety-like behaviors, serum levels insulin, leptin, corticosterone, triglycerides were determined. decreased the intake chow, but kept unaltered food. During elevated plus maze...
Abstract Background The simultaneous rise in the prevalence of asthma and obesity world, have demonstrated importance development treatment strategies. purpose this study was to evaluate short‐ long‐term results interdisciplinary therapy on inflammatory biomarkers lung function asthmatics obese adolescents. Methods Seventy‐six post‐pubertal adolescents were recruited, including 50 non‐asthmatics [body mass index (BMI), 36 ± 5 kg/m 2 ) 26 (BMI, 39 4 ). Body composition measured by...
Abstract Aging and physical inactivity are two factors that favors the development of cardiovascular disease, metabolic syndrome, obesity, diabetes, sleep dysfunction. In contrast, adoption a habitual moderate exercise may present non-pharmacological treatment alternative for disorders. We aimed to assess effects training on quality profile elderly people with sedentary lifestyle. Fourteen male sedentary, healthy, volunteers performed 60 minutes/day, 3 days/week 24 wk at work rate equivalent...
Obesity is a chronic disease defined by an excess amount of adipose tissue and presents low-grade inflammatory state, increasing cardiovascular risk.To assess the effect weight loss magnitude on profile carotid intima-media thickness (cIMT) in obese adolescents engaged interdisciplinary therapy.Seventy-seven postpubertal with BMI greater than 95th percentile (37·18 ± 5·14), both genders between ages 14 19 years (16·74 1·59) were subjected to 1-year period intervention (nutrition, psychology,...
The prevention of obesity and health concerns related to body fat is a major challenge worldwide. aim this study was investigate the role medically supervised, multidisciplinary approach, on reduction in prevalence comorbidities, inflammatory profile, neuroendocrine regulation energy balance sample obese adolescents. A total 97 postpuberty adolescents were enrolled study. Body composition, neuropeptides, adipokines analysed. metabolic syndrome defined by International Diabetes Federation...
Ginkgo biloba extract (GbE) has been indicated as an efficient medicine for the treatment of diabetes mellitus type 2. It remains unclear if its effects are due to improvement insulin signaling cascade, especially in obese subjects. The aim present study was evaluate effect GbE on tolerance, food intake, body adiposity, lipid profile, fasting insulin, and muscle levels receptor substrate 1 (IRS-1), protein tyrosine phosphatase 1B (PTP-1B), kinase B (Akt), well Akt phosphorylation,...