A5105180992- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Sports Performance and Training
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Developmental Biology and Gene Regulation
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Metabolism and Genetic Disorders
- Telomeres, Telomerase, and Senescence
- TGF-β signaling in diseases
- Physical Education and Sports Studies
- Kruppel-like factors research
Leidos (United States)
2024
Frederick National Laboratory for Cancer Research
2024
Leidos Biomedical Research Inc. (United States)
2024
Universidade de São Paulo
2009-2023
Johns Hopkins Medicine
2018-2021
Johns Hopkins University
2018-2021
Hospital Universitário da Universidade de São Paulo
2016
Institute of Biomedical Science
2016
Universidade de Mogi das Cruzes
2012
Universidade Brasil
2008
Abstract Background Cancer is considered the second leading cause of death in world, and for treatment this disease, pharmacological intervention strategies are frequently based on chemotherapy. Doxorubicin (DOX) one most widely used chemotherapeutic agents clinical practice treating a number solid tumours. The with DOX mimics some effects cancer cachexia, such as anorexia, asthenia, decreases fat skeletal muscle mass fatigue. We observed that increased systemic insulin resistance caused...
Abstract This study compared four different intensities of a bench press exercise for muscle soreness, creatine kinase activity, interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2) concentrations in the blood. Thirty-five male Brazilian Army soldiers were randomly assigned to one five groups: 50% one-repetition maximum (1-RM), 75% 1-RM, 90% 110% control group that did not perform exercise. The total volume (sets × repetitions load) was matched among...
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and RET/PTC rearrangements represent key genetic events frequently associated to this cancer, enhancing proliferation dedifferentiation by activation of RET/PTC-RAS-BRAF-mitogen-activated protein kinase (MAPK) pathway. Recently, let-7 microRNA was found reduce RAS levels in lung acting as a tumor suppressor gene. Here, we report that RET/PTC3 oncogenic PCCL3 rat cells markedly reduces let-7f expression. Moreover,...
The effects of chronic aerobic exercise upon lipid profile has been previously demonstrated, but few studies showed this effect under resistance conditions.The aim study was to examine the different loads on blood lipids.Thirty healthy, untrained male volunteers were allocated randomly into four groups based at percentages one repetition maximum (1 RM); 50%-1 RM, 75%-1 90%-1 and 110%-1 RM. total volume (sets x reps load) equalized. (Triglycerides [TG], HDL-cholesterol [HDL-c],...
Mutually exclusive genetic alterations in the RET, RAS, or BRAF genes, which result constitutively active mitogen-activated protein kinase (MAPK) signaling, are present about 70% of papillary thyroid carcinomas (PTCs). However, effect MAPK activation on other signaling pathways involved oncogenic transformation, such as Notch, remains unclear. In this study, we tested hypothesis that pathway regulates Notch and plays a role PTC cell proliferation. Conditional induction oncogenes RET/PTC3...
Cancer cachexia induces loss of fat mass that accounts for a large part the dramatic weight observed both in humans and animal models; however, literature does not provide consistent information regarding set point how different visceral adipose tissue depots contribute to this symptom. To evaluate that, 8-week-old male Wistar rats were subcutaneously inoculated with 1 ml (2×10 7 ) tumour cells (Walker 256). Samples white (WAT) collected at days 0, 4, 14 stored −80 °C (seven ten animals/each...
Abstract Skeletal muscle is the source of pro‐ and anti‐inflammatory cytokines, recently, it has been recognized as an important interleukin‐6 (IL‐6). Acute physical exercise known to induce a pro‐inflammatory cytokine profile in plasma. However, effect chronic production cytokines by skeletal never examined. We assessed IL‐6, TNF‐α, IL‐1β IL‐10 levels rats submitted endurance training. Animals were randomly assigned either sedentary group (S, n = 7) or trained (T, 8). Trained ran on...
Isocitrate deyhydrogenase (IDH) mutant glioma comprises the majority of grades II-III gliomas and nearly all secondary glioblastomas. These progressive arise from mutations in IDH1 or IDH2 that pathologically produce D-2-hydroxyglutarate (2HG), which interferes with cell reactions using alpha ketoglutarate, leading to a hypermethylated genome epigenetic dysregulation gene expression initiating tumorigenesis.Human wild type (wt) R132H lines patient-derived xenografts (PDXs) were used evaluate...
Background Cachexia is a systemic syndrome leading to body wasting, inflammation, and metabolic chaos. It progressive condition, little known about its dynamics. Detection of the early signs disease may lead attenuation associated symptoms. The white adipose tissue an organ with endocrine functions, capable synthesising secreting plethora proteins, including cytokines, chemokines, adipokines. well established that different depots demonstrate heterogeneous responses physiological...
Abstract The syndrome of cancer cachexia is accompanied by several alterations in lipid metabolism, and the liver markedly affected. Previous studies showed that moderate exercise training may prevent fat accumulation through diminished delivery lipids to liver, increased hepatic oxidation incorporation triacylglycerol (TAG) into very low density lipoprotein (VLDL). Our aim was examine influence intensity (8 weeks) upon TAG content, VLDL assembly secretion, apolipoprotein B (apoB) microsomal...
Mechanistic target of rapamycin complex (mTORC)1 activity is increased in adipose tissue obese insulin-resistant mice, but its role the regulation inflammation unknown. Herein, we investigated effects adipocyte mTORC1 deficiency on and glucose homeostasis. For this, mice with raptor deletion controls fed a chow or high-fat diet were evaluated for body mass, adiposity, homeostasis, inflammation. Despite reducing promoted hepatic steatosis, insulin resistance, (increased infiltration...
We tested the effects of a cancer cachexia-anorexia sydrome upon balance anti and pro-inflammatory cytokines in hypothalamus sedentary or trained tumour-bearing (Walker-256 carcinosarcoma) rats.Animals were randomly assigned to control (SC), (ST), pair-fed (SPF) groups or, exercised (EC), (ET) (EPF) groups. Trained rats ran on treadmill (60%VO2max) for 60 min/d, 5 days/wk, 8 wks. evaluated food intake, leptin cytokine (TNF-α, IL1β) levels hypothalamus.The cumulative intake serum...
Papillary thyroid cancer (PTC) is the most incident histotype of cancer. A certain fraction PTC cases (5%) are irresponsive to conventional treatment, and refractory radioiodine therapy. The current prognostic factors for aggressiveness mainly based on tumor size, presence lymph node metastasis, extrathyroidal invasion and, more recently, BRAFT1799A mutation. MicroRNAs (miRNAs) have been described as promising molecular markers their deregulation observed in a wide range tumors. Recent...
The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat (HFD). After 15 weeks, HFD randomly assigned to following groups: submitted HFD, which sedentary (sedentary n = 8) trained (trained 8); energy-restriction (ER), ER, 8). Trained ran a treadmill at 55% VO2max for 60 min/day, 5...