A5074429642- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Genetics and Physical Performance
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and biosynthesis
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Heart Rate Variability and Autonomic Control
- Physical Education and Pedagogy
- Children's Physical and Motor Development
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Immune cells in cancer
- Cerebral Palsy and Movement Disorders
Universidade Estadual de Londrina
2009-2025
Universidade de São Paulo
2013-2017
Universidade Cidade de São Paulo
2013
Universidade Estadual de Maringá
2012
Victoria University
2010
Universidade Católica de Brasília
2010
Unidad Ejecutora Lillo
2008
Numerous studies address the physiology of adipose tissue (AT). The interest surrounding AT is primarily result epidemic outburst obesity in various contemporary societies. Briefly, two primary metabolic activities white include lipogenesis and lipolysis. Throughout last decades, a new model has emerged. Although was considered to be an abundant energy source, it currently prolific producer biologically active substances, and, consequently, now recognized as endocrine organ. In addition...
Palmitoleic acid was previously shown to improve glucose homeostasis by reducing hepatic production and enhancing insulin-stimulated uptake in skeletal muscle. Herein we tested the hypothesis that palmitoleic positively modulates metabolism adipocytes.For this, both differentiated 3 T3-L1 cells treated with either (16:1n7, 200 μM) or palmitic (16:0, for 24 h primary adipocytes from mice 16:1n7 (300 mg/kg/day) oleic (18:1n9, 300 gavage 10 days were evaluated uptake, oxidation, conversion...
We investigated whether palmitoleic acid, a fatty acid that enhances whole body glucose disposal and suppresses hepatic steatosis, modulates triacylglycerol (TAG) metabolism in adipocytes. For this, both differentiated 3T3-L1 cells treated with either (16:1n7, 200 μM) or palmitic (16:0, for 24 h primary adipocytes from wild-type PPARα-deficient mice 16:1n7 (300 mg·kg(-1)·day(-1)) oleic (18:1n9, 300 by gavage 10 days were evaluated lipolysis, TAG, glycerol 3-phosphate synthesis gene protein...
Abstract In response to cold, brown adipose tissue (BAT) increases its metabolic rate and expands mass produce heat required for survival, a process known as BAT recruitment. The mechanistic target of rapamycin complex 1 (mTORC1) controls metabolism, cell growth proliferation, but role in regulating recruitment chronic cold stimulation is unknown. Here, we show that activates mTORC1 BAT, an effect depends on the sympathetic nervous system. Adipocyte-specific loss mice completely blocks...
Melatonin, the main hormone produced by pineal gland, is secreted in a circadian manner (24-hr period), and its oscillation influences several biological rhythms, such as regulation of clock genes expression (chronobiotic effect) modulation endocrine functions peripheral tissues. Assuming that synchronization can play role energy metabolism it influenced melatonin, our study was designed to assess possible alterations consequence melatonin absence on epididymal adipose tissue male Wistar...
Scope We tested herein the hypothesis that peroxisome proliferator activated receptor γ (PPARγ) is a major mediator of omega‐3 ( n ‐3) protective actions against high‐fat diet (HFD) induced obesity, glucose intolerance, and adipose tissue inflammation. Methods results C57BL6 wild‐type fat‐1 transgenic ) mice were fed low‐fat (LFD) or HFD, treated not with PPARγ antagonist, evaluated for energy balance, adiposity, tolerance, Fat‐1 protected from fasting hyperglycemia, inhibition completely...
Glucocorticoid (GC) in excess promotes the redistribution of adipose tissue from peripheral to central sites body. In this study, we characterized an experimental condition prolonged GC and investigated its effect on lipogenic metabolism white tissue.Twenty male Wistar rats were divided into control (CON) dexamethasone-treated (DEX) groups. DEX group received dexamethasone (0.25 mg kg(-1) day(-1) ) during 4 weeks, while CON saline. Animals killed subcutaneous (SC), retroperitoneal (RP)...
Mechanistic target of rapamycin complex (mTORC)1 activity is increased in adipose tissue obese insulin-resistant mice, but its role the regulation inflammation unknown. Herein, we investigated effects adipocyte mTORC1 deficiency on and glucose homeostasis. For this, mice with raptor deletion controls fed a chow or high-fat diet were evaluated for body mass, adiposity, homeostasis, inflammation. Despite reducing promoted hepatic steatosis, insulin resistance, (increased infiltration...
While chemotherapy treatment can be lifesaving, it also has adverse effects that negatively impact the quality of life. To investigate doxorubicin on body weight loss, strength and muscle mass physical function impairments, all key markers cachexia, sarcopenia, frailty. Seventeen C57/BL/6 mice were allocated into groups. 1) Control (n = 7): exposed to intraperitoneal (i.p.) injections saline solution. 2) Dox 10): cycles (total dose 18 mg/kg divided over 15 days). The loss decreased food...
Creatine has demosntrated protective effects against muscle dysfunction, but its potential protection doxorubicin-induced cardio and skeletal toxicity remains poorly understood. We aimed to investigate the of creatine supplementation myotoxicity. This study analyzed twenty male C57BL/6J mice, divided into three groups: Control (C; n = 6), Dox (n 7) which received weekly doxorubicin injections (16 mg/kg i.p. in 20 days) DoxCr with both (4%). Doxorubicin administration induced atrophy extensor...
mTOR inhibition with rapamycin induces a diabetes-like syndrome characterized by severe glucose intolerance, hyperinsulinemia, and hypertriglyceridemia, which is due to increased hepatic production as well reduced skeletal muscle uptake adipose tissue PPARγ activity. Herein, we tested the hypothesis that pharmacological activation attenuates associated chronic inhibition. Rats treated inhibitor (2 mg·kg −1 ·day ) in combination or not ligand rosiglitazone (15 for 15 days were evaluated...
BAT and iWAT mTORC2 is inhibited by cold acclimation, but its residual activity required for cold-induced increases in total UCP-1 content thermogenic capacity, not glucose uptake mTORC1 activity. The impaired capacity induced adipocyte deficiency are compensated activation of muscle shivering cold-acclimated mice.
Diabetes mellitus (DM) is a great public health problem, which attacks part of the world population, being characterized by an imbalance in body glucose homeostasis. Physical exercise pointed as protective agent and also recommended to people with DM. As pancreatic islets present important role homeostasis, we aim study physical (chronic adaptations acute responses) functionality Wistar male rats. First, animals were divided into two groups: sedentary (S) aerobic trained (T). At end 8 weeks,...
Abstract The aim of this study was to investigate the effects walking training with and without blood flow restriction (BFR) on heart rate (HR) variability (HRV) kinetics HRV recovery. Twenty-one men (53.5±3.2 years; 82.4±13.5 kg; 168.5±7.2 cm) were randomly assigned two groups: walk group (BFR-W; n=11) (NOR-W; n=10) BFR. Before after training, all subjects underwent body composition evaluation, incremental test, one constant load test. Walking performed 3 times/week, during 6 weeks. Each...
This study aimed to determine the role of mammalian target rapamycin (mTORC1) activation and catabolic markers in resistance training's (RT) antiatrophy effect during cachexia-induced muscle loss.Myofiber atrophy was induced by injecting Walker 256 tumor cells into rats exposed or not RT protocol ladder climbing. The RT-induced anabolic stimulation investigated tumor-bearing with mTORC1 inhibitor rapamycin, cross-sectional areas skeletal were evaluated identify hypertrophy. Components...
Nakamura, FY, Pereira, G, Chimin, P, Siqueira-Pereira, TA, Simões, HG, and Bishop, DJ. Estimating the perceived exertion threshold using OMNI scale. J Strength Cond Res 24(6): 1602-1608, 2010-This study aimed to determine if scale with cycle ergometer pictorial format can be used estimate (PETOMNI) nonexhaustive PET (PETOMNI5-8) compare correlate these estimates PETBorg, PETBorg14-17, critical power (CP). During different days, 13 men performed 4 high-intensity constant-loads work bouts...
The study aimed to verify the pattern of critical load (CL) and anaerobic swim capacity (ASC) during a twelve-week continuous program, after 3 9 days detraining, in short-term retraining swimming rats.Animals were distributed into four groups: control (CG), trained (TG), detrained (D3G) (D9G).They submitted CL test exercise.TG group continuously 12 weeks.D3G D9G groups for five weeks, stopped three nine days, respectively, came back complete training period.ANOVA two-way repeated measures...