A5078210137- Mycotoxins in Agriculture and Food
- Veterinary Oncology Research
- Veterinary medicine and infectious diseases
- Microbial infections and disease research
- Carcinogens and Genotoxicity Assessment
- Animal Nutrition and Physiology
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Bird parasitology and diseases
- Probiotics and Fermented Foods
- Meat and Animal Product Quality
- Wheat and Barley Genetics and Pathology
- Plant and fungal interactions
- Vector-borne infectious diseases
- T-cell and Retrovirus Studies
- Turtle Biology and Conservation
- Helicobacter pylori-related gastroenterology studies
- Parasite Biology and Host Interactions
- Infectious Diseases and Mycology
- Marine animal studies overview
- Fungal Infections and Studies
- Toxin Mechanisms and Immunotoxins
- Cardiovascular Conditions and Treatments
- Toxoplasma gondii Research Studies
- Nail Diseases and Treatments
Universidade Estadual de Londrina
2016-2025
Toxalim Research Centre in Food Toxicology
2017
Université de Toulouse
2012
Deoxynivalenol (DON) and fumonisins (FB) are mycotoxins produced by Fusarium species, which naturally co-occur in animal diets. The gastrointestinal tract represents the first barrier met exogenous food/feed compounds. purpose of present study was to investigate effects DON FB, alone combination, on some intestinal parameters, including morphology, histology, expression cytokines junction proteins. A total twenty-four 5-week-old piglets were randomly assigned four different groups, receiving...
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Abstract Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, deepoxy-deoxynivalenol (deepoxy-DON DOM-1) 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and molecular basis for reduced investigated. In human epithelial cells, deepoxy-DON 3-epi-DON were not cytotoxic, did change oxygen consumption impair barrier function. explants, exposure 4 hours 10 μM DON induced lesions seen in...
Mycotoxins are the most common contaminants of food and feed worldwide considered an important risk factor for human animal health. Oxidative stress occurs in cells when concentration reactive oxygen species exceeds cell’s antioxidant capacity. causes DNA damage, enhances lipid peroxidation, protein damage cell death. This review addresses toxicity major mycotoxins, especially aflatoxin B 1 , deoxynivalenol, nivalenol, T-2 toxin, fumonisin ochratoxin, patulin zearalenone, relation to...
ABSTRACT An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development colorectal cancers. Deoxynivalenol (DON) is most prevalent mycotoxin that contaminates staple food—especially cereal products—in Europe and North America. This study investigates effect food contaminant DON on genotoxicity E. colibactin. In vitro , intestinal epithelial cells were coexposed vivo...
Deoxynivalenol (DON), one of the most widespread mycotoxins in Europe, and cadmium (Cd), a environmental pollutant, are common food contaminants. They exert adverse effects on different organs including kidney, liver, intestine. The intestine is target DON Cd when they ingested. Most studies have focused their individual whereas combined toxicity has rarely been studied. aim this study was thus to evaluate intestinal barrier function vitro vivo. In vitro, Caco-2 cells were treated with...
The purpose of the present study was to investigate effects phytic acid (IP6) on morphological and immunohistochemical parameters oxidative stress response in intestinal explants pigs exposed fumonisin B1 (FB1) and/or deoxynivalenol (DON). jejunal were following treatments: vehicle, IP6 5 mM, DON 10 µM, FB1 70 µM + mM. decrease villus height goblet cell density more evident treatments. In addition, a significant increase apoptosis proliferation E-cadherin expression observed same groups....
The mycotoxins deoxynivalenol (DON) and nivalenol (NIV), worldwide cereal contaminants, raise concerns for animal human gut health, following contaminated food or feed ingestion. impact of DON NIV on intestinal mucosa was investigated after acute exposure, in vitro vivo. histological changes induced by were analyzed four-hour exposure pig jejunum explants loops, two alternative models. On explants, dose-dependent increases the NIV, with a two-fold increase lesion severity at 10 µM NIV. had...
Mycotoxin mitigation is of major interest as ingestion mycotoxins results in poor animal health, decreased productivity, well substantial economic losses. A feed additive (FA) consisting a combination bacteria (Eubacterium BBSH797) and enzyme (fumonisin esterase FumD) was tested pigs for its ability to neutralize the effects mono- co-contaminated diets with deoxynivalenol (DON) fumonisins (FB) on hematology, biochemistry, tissue morphology, immune response. Forty-eight animals, allocated...
Deoxynivalenol (DON) is a predisposing factor for necrotic enteritis. This study aimed to investigate the effects of DON and Clostridium perfringens (CP) challenge on intestinal morphology, morphometry, oxidative stress, immune response broilers. Additionally, we evaluated potential Lactobacillus spp. mixture as an approach mitigate damage induced by challenge. One-day-old broiler chickens (n = 252) were divided into seven treatment groups: Control, DON, CP, CP + VL (DON viable mixture), HIL...
Fusariotoxins such as fumonisin B1 (FB1) and deoxynivalenol (DON) cause deleterious effects on the intestine of pigs. The aim this study was to evaluate effect these mycotoxins, alone in combination, jejunal explants from piglets, using histological, immunohistochemical ultrastructural assays. Five 24-day old pigs were used for sampling explants. Forty-eight sampled each animal. Explants incubated 4 hours culture medium containing FB1 (100 µM), DON (10 µM) both mycotoxins µM plus 10 DON)....
Aflatoxin B₁ (AFB₁), a mycotoxin found in food and feed, exerts harmful effects on humans animals. The liver is the earliest target of AFB₁, its have been evaluated animal models exposed to acute or chronic doses. Considering possibility sporadic ingestion AFB₁-contaminated food, this study investigated impact single oral dose AFB₁ function/cytokines lymphoproliferative response mice. C57BL/6 mice were treated with (44, 442 663 μg AFB₁/kg body weight) first day. Liver function (ALT, γ-GT,...
Fumonisins (FBs) are mycotoxins produced by Fusarium species that can contaminate human food and animal feed. Due to the harmful effects of FBs on animals, European Union (EU) defined a recommendation maximum 5 mg (B1 + B2)/kg for complete feed swine 1 µg FBs/kg body weight per day as tolerable daily intake humans. The aim this study was evaluate toxicity dietary exposure low doses FBs, including dose below EU regulatory limits. Four groups 24 weaned castrated male piglets were exposed...
Ingestion of deoxynivalenol (DON), one the most common mycotoxin contaminants cereals, leads to adverse effects for animal and human health. Bacterial biotransformation is a strategy mitigate toxicity this mycotoxin. The present study aims evaluate two bacterial biotranformation products DON: 3-epi-deoxynivalenol (3-epi-DON) de-epoxy-deoxynivalenol (DOM-1) through zootechnical, hematological, histological immunological assays. Twenty-four 4-weeks-old piglets received control diet or...
While chemotherapy treatment can be lifesaving, it also has adverse effects that negatively impact the quality of life. To investigate doxorubicin on body weight loss, strength and muscle mass physical function impairments, all key markers cachexia, sarcopenia, frailty. Seventeen C57/BL/6 mice were allocated into groups. 1) Control (n = 7): exposed to intraperitoneal (i.p.) injections saline solution. 2) Dox 10): cycles (total dose 18 mg/kg divided over 15 days). The loss decreased food...
Creatine has demosntrated protective effects against muscle dysfunction, but its potential protection doxorubicin-induced cardio and skeletal toxicity remains poorly understood. We aimed to investigate the of creatine supplementation myotoxicity. This study analyzed twenty male C57BL/6J mice, divided into three groups: Control (C; n = 6), Dox (n 7) which received weekly doxorubicin injections (16 mg/kg i.p. in 20 days) DoxCr with both (4%). Doxorubicin administration induced atrophy extensor...
Abstract Aims This study aims to evaluate the antiviral activity of sophorolipids against Herpes simplex virus (HSV-1) and develop an anti-herpetic formulation for treatment cutaneous lesions caused by HSV-1. Methods Results The antiherpetic was evaluated in vitro both sensitive (KOS) acyclovir-resistant (AR) HSV-1 strains. used as a model assess non-enveloped viruses Poliovirus viruses. results showed that exhibit effective strains with low cytotoxicity VERO cells. However, poliovirus not...
This study presents the development and validation of a Health Index (HI) to assess overall health stranded marine tetrapods (seabirds, sea turtles, mammals). The HI is based on parameters collected during necropsies histopathological analyses, including body condition, systemic conditions (macroscopic by histopathology), cutaneous injuries, organized lesions, parasitosis, lymphoid depletion, thyroid alterations. was applied data from 6,332 along Brazilian coast. Results showed that...