A5046768235- Mycotoxins in Agriculture and Food
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Carcinogens and Genotoxicity Assessment
- Wheat and Barley Genetics and Pathology
- Chromosomal and Genetic Variations
- Veterinary medicine and infectious diseases
- Plant and fungal interactions
- Genetic and phenotypic traits in livestock
- Meat and Animal Product Quality
- Molecular Biology Techniques and Applications
- Plant Disease Resistance and Genetics
- Plant Toxicity and Pharmacological Properties
- Immunotoxicology and immune responses
- Microbial infections and disease research
- Agricultural safety and regulations
- Effects of Radiation Exposure
- Probiotics and Fermented Foods
- Indoor Air Quality and Microbial Exposure
- Enterobacteriaceae and Cronobacter Research
- Helicobacter pylori-related gastroenterology studies
- Occupational and environmental lung diseases
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- NF-κB Signaling Pathways
Université de Toulouse
2014-2024
Université Toulouse III - Paul Sabatier
2016-2024
École Nationale Vétérinaire de Toulouse
1997-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2024
Toxalim Research Centre in Food Toxicology
2015-2024
Aix-Marseille Université
2015
Institut National de la Recherche Agronomique
1998-2014
Institut National Polytechnique de Toulouse
2012-2014
Pharmacochimie et Pharmacologie pour le Développement
2009
École Nationale Supérieure Agronomique
2007
We have developed a panel of 152 whole-genome radiation hybrids by fusing irradiated diploid pig lymphocytes or fibroblasts with recipient hamster permanent cells. The number and size the porcine chromosome fragments retained in each hybrid clone were checked fluorescence situ hybridization SINE probe primed labeling (PRINS) SINE-specific primers. A strategy based on interspersed repetitive sequence polymerase chain reaction (IRS-PCR) was for selected clones to determine if large painted...
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
A panel of 27 pig × rodent somatic cell hybrids was produced and characterized cytogenetically. The first step this study consisted hybridizing a SINE probe to GTG-banded metaphases each hybrid clone in order count identify the normal chromosomes detect rearranged ones. second using DNA as after pIRS-PCR (porcine interspersed repetitive sequence-polymerase chain reaction) amplification highly enrich it sequences. These probes, hybridized metaphase chromosomes, enabled identification complete...
Background Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As traits are difficult or impossible measure directly, potential indirect criteria measures immune (ITs). Our underlying hypothesis that levels ITs with no focus on specific define an individual's immunocompetence and thus predict response general. Since variation depends genetic, environmental probably epigenetic factors, our aim was estimate the relative...
Trichothecenes induce changes in the intestinal barrier function through decreased expression of cell junction proteins and apoptosis enterocytes. The mitogen activated protein kinases (MAPK) play an important role signaling pathways turnover differentiation. Using ex vivo approaches, purpose this study was to investigate ability low doses DON histological intestine activate MAPK ERK 1/2, p38 JNK. Twelve weaning piglets received during four weeks a control diet or DON-contaminated (2.3 mg...
The food-associated mycotoxin deoxynivalenol (DON) is known to affect intestinal functions. However, its effect on mucus poorly characterized.We analyzed the effects of DON human goblet cells (HT29-16E cells) and porcine explants. Results showed that subtoxic doses (as low as 1 μM) decreased mucin (MUC) production. qPCR analysis demonstrated this inhibition was due a specific decrease in level mRNA encoding for membrane-associated (MUC1) secreted MUCs (MUC2, MUC3). Mechanistic studies relied...
ABSTRACT An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development colorectal cancers. Deoxynivalenol (DON) is most prevalent mycotoxin that contaminates staple food—especially cereal products—in Europe and North America. This study investigates effect food contaminant DON on genotoxicity E. colibactin. In vitro , intestinal epithelial cells were coexposed vivo...
Food and feed can be naturally contaminated by several mycotoxins, concern about the hazard of exposure to mycotoxin mixtures is increasing. In this study, more than 800 metabolites were analyzed in 524 finished pig samples collected worldwide. Eighty-eight percent co-contaminated with deoxynivalenol (DON) other regulated/emerging mycotoxins. The Top 60 emerging/regulated mycotoxins co-occurring DON shows that 48%, 13%, 8% 12% are produced Fusarium, Aspergillus, Penicillium Alternaria...
Deoxynivalenol (DON), one of the most widespread mycotoxins in Europe, and cadmium (Cd), a environmental pollutant, are common food contaminants. They exert adverse effects on different organs including kidney, liver, intestine. The intestine is target DON Cd when they ingested. Most studies have focused their individual whereas combined toxicity has rarely been studied. aim this study was thus to evaluate intestinal barrier function vitro vivo. In vitro, Caco-2 cells were treated with...