A5065473864- Antimicrobial Peptides and Activities
- Mycotoxins in Agriculture and Food
- Probiotics and Fermented Foods
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
- Biochemical and Structural Characterization
- Chemical Synthesis and Analysis
- Synthesis of Organic Compounds
- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Escherichia coli research studies
- Phytochemicals and Antioxidant Activities
- Antimicrobial agents and applications
- Antibiotic Resistance in Bacteria
- Protein Hydrolysis and Bioactive Peptides
- Glycosylation and Glycoproteins Research
- Advanced Glycation End Products research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- HIV Research and Treatment
- Plant Toxicity and Pharmacological Properties
- Antibiotics Pharmacokinetics and Efficacy
- Indoor Air Quality and Microbial Exposure
- Sesquiterpenes and Asteraceae Studies
- Marine Sponges and Natural Products
- Metabolism, Diabetes, and Cancer
Aix-Marseille Université
2016-2025
Centrale Marseille
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Institut des Sciences Moléculaires de Marseille
2016-2024
Queens University
2024
Queen's University Belfast
2024
University of Oxford
2024
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2009-2011
Physique des interactions ioniques et moléculaires
2010
Centre de Gestion Scientifique
2009
A key concern in agriculture is how to feed the expanding population and safeguard environment from ill effects of climate change. To a growing global population, food production security are significant problems, as output may need double by 2050. Thus, more innovative effective approaches for increasing agricultural productivity (hence, production) required meet rising demand food. The world’s most widely cultivated grains include corn, wheat, rice, which serve foundation basic foods. This...
The V3 loop of the human immunodeficiency virus (HIV)-1 surface envelope glycoprotein gp120 is a sphingolipid-binding domain mediating attachment HIV-1 to plasma membrane microdomains (rafts). Sphingolipid-induced conformational changes in are required for fusion. Galactosylceramide and sphingomyelin have been detected highly purified preparations prion rods, suggesting that protein (PrP) may interact with selected sphingolipids. Moreover, major transition Alzheimer β-amyloid peptide has...
Strong tight junctions and curtailed inflammatory responses under stressful conditions are key for optimal digestive health. Bacillus-based probiotics increasingly being used to maintain broilers' health, but their mode of action is often not well-defined. In the present study we Caco-2 cells as a model intestinal epithelia assessed effect three on barrier function inflammation. Experimental results showed that one tested strains, Bs 29784, significantly reinforced integrity basal through an...
A human-bacterium symbiosis leads to the production of an antipathogenic and safe RiPP with a novel thioether network.
Enteropathogenic Escherichia coli (EPEC) induces a severe watery diarrhea responsible for several hundred thousand infant deaths each year by process correlated with the loss (effacement) of absorptive microvilli. Effacement is linked to locus enterocyte effacement pathogenicity island that encodes an “injection system,” “effector” proteins, and Intimin outer membrane protein. Here, we reveal ( i ) two-step process, ii requires cooperative action three injected effectors (Map, EspF, Tir) as...
The food-associated mycotoxin deoxynivalenol (DON) is known to affect intestinal functions. However, its effect on mucus poorly characterized.We analyzed the effects of DON human goblet cells (HT29-16E cells) and porcine explants. Results showed that subtoxic doses (as low as 1 μM) decreased mucin (MUC) production. qPCR analysis demonstrated this inhibition was due a specific decrease in level mRNA encoding for membrane-associated (MUC1) secreted MUCs (MUC2, MUC3). Mechanistic studies relied...
The molecular cross-talk between commensal bacteria and the gut play an important role in maintenance of intestinal homeostasis general health. Here, we studied impact a major Gram-positive anaerobic bacterium human microbiota, that is, Ruminococcus gnavus on glycosylation pattern production mucus by goblet cells.Our results showed R. E1 specifically increases expression level glyco-conjugates cells colonic mucosa mono-associated mice with as well HT29-MTX cells. Such effect was mediated...
Abstract Free‐radical copolymerization of cyclic ketene acetals (CKAs) and vinyl ethers (VEs) was investigated as an efficient yet simple approach for the preparation functional aliphatic polyesters. The CKA VE first predicted to be quasi‐ideal by DFT calculations. theoretical prediction experimentally confirmed 2‐methylene‐1,3‐dioxepane (MDO) butyl ether (BVE), leading r MDO =0.73 BVE =1.61. We then illustrated versatility this preparing different polyesters: 1) copolymers functionalized...
Abstract Background Mycobacterium abscessus , a fast-growing non-tuberculous mycobacterium, is an emerging opportunistic pathogen responsible for chronic bronchopulmonary infections in people with respiratory diseases such as cystic fibrosis (CF). Due to its intrinsic polyresistance wide range of antibiotics, most treatments M. pulmonary are poorly effective. In this context, antimicrobial peptides (AMPs) active against bacterial strains and less prompt cause resistance, represent good...
ABSTRACT Glycosphingolipids from human erythrocytes mediate CD4-dependent fusion with cells expressing immunodeficiency virus type 1 (HIV-1) envelope glycoproteins. To identify the glycosphingolipid(s) which participates in process, we have analyzed interaction of HIV-1 gp120 (X4 and R5X4 isolates) reconstituted membrane microdomains erythrocyte glycosphingolipids. We identified globotriaosylceramide (Gb3) ganglioside GM3 as main glycosphingolipids recognized by gp120. In presence CD4, Gb3...
Enteropathogenic Escherichia coli (EPEC) infection of the human small intestine induces severe watery diarrhoea linked to a rather weak inflammatory response despite EPEC's in vivo capacity disrupt epithelial barrier function. Here, we demonstrate that EPEC flagellin triggers secretion pro-inflammatory cytokine, interleukin (IL)-8, from (Caco-2) and large (T84) intestinal epithelia model systems. Interestingly, IL-8 required basolateral T84 cells implying must penetrate barrier. In contrast,...
Antimicrobial peptides (AMPs) are promising drug candidates to target multi-drug resistant bacteria. The rumen microbiome presents an underexplored resource for the discovery of novel microbial enzymes and metabolites, including AMPs. Using functional screening computational approaches, we identified 181 potentially AMPs from a bacterial metagenome. Here, show that three selected (Lynronne-1, Lynronne-2 Lynronne-3) were effective against numerous pathogens, methicillin-resistant...
With the aim to develop effective and selective human tyrosinase inhibitors, we investigated aurone derivatives whose B-ring was replaced by a non-oxidizable 2-hydroxypyridine-N-oxide (HOPNO) moiety. These aurones were synthesized evaluated as inhibitors of purified tyrosinase. Excellent inhibition activity revealed rationalized theoretical calculations. The backbone especially found play crucial role, HOPNO moiety alone provided very modest on Furthermore, in vitro confirmed measuring...