A5101842505- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Probiotics and Fermented Foods
- Venomous Animal Envenomation and Studies
- Neurobiology and Insect Physiology Research
- Antifungal resistance and susceptibility
- Nicotinic Acetylcholine Receptors Study
- vaccines and immunoinformatics approaches
- Bacterial biofilms and quorum sensing
- Alzheimer's disease research and treatments
- Bacteriophages and microbial interactions
- Cholinesterase and Neurodegenerative Diseases
- Antimicrobial agents and applications
- Nosocomial Infections in ICU
- Protein Hydrolysis and Bioactive Peptides
- Synthesis and Biological Evaluation
- Amphibian and Reptile Biology
- Click Chemistry and Applications
Queen's University Belfast
2014-2021
Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with advantage (given their source) that they should be readily translatable to medicinal products. It is also plausible truncated versions will display some biological activities parent peptide, benefit less costly synthesize using solid-phase chemistry. The LL-37, and two mimetics, KE-18 KR-12, were tested for inhibitory effects antibiofilm properties against Candida...
Antimicrobial peptides (AMPs) are promising drug candidates to target multi-drug resistant bacteria. The rumen microbiome presents an underexplored resource for the discovery of novel microbial enzymes and metabolites, including AMPs. Using functional screening computational approaches, we identified 181 potentially AMPs from a bacterial metagenome. Here, show that three selected (Lynronne-1, Lynronne-2 Lynronne-3) were effective against numerous pathogens, methicillin-resistant...
DBA/2 mice were chronically infused with saline (control), 4 mg/kg/hr of nicotine, mecamylamine or nicotine+mecamylamine for 7 days. The binding L-[3H]nicotine was significantly increased in seven eight brain regions dissected from 5 hr after cessation drug treatment. Similarly, [3H]nicotine six by chronic Treatment both drugs led to increases that at least the sum those observed either alone. These partially reversed 48 No significant effects nicotine treatment on alpha-[125I]bungarotoxin...
Abstract Biofilms containing Candida albicans are responsible for a wide variety of clinical infections. The protective effects the biofilm matrix, low metabolic activity microorganisms within and their high mutation rate, significantly enhance resistance biofilms to conventional antimicrobial treatments. Peptoids peptide‐mimics that share many features host defence peptides but have increased proteases therefore better stability in vivo. library peptoids was tested against monospecies...
Polymicrobial biofilms consisting of fungi and bacteria are frequently formed on endotracheal tubes may contribute to development ventilator associated pneumonia (VAP) in critically ill patients. This study aimed determine the role early Candida albicans supporting dual-species (dual-kingdom) biofilm formation with respiratory pathogens vitro , investigated effect targeted antifungal treatment bacterial cells within biofilms. Dual-species between C . three commonly VAP ( Pseudomonas...
Bradykinin-related peptides (BRPs) are significant components of the defensive skin secretions many anuran amphibians, and these represent source most diverse spectrum such so far encountered in nature. Of families bioactive that have been identified from this source, BRPs uniquely appear to homologues counterparts specific distributions receptor targets within discrete vertebrate taxa, ranging fishes through mammals. Their broad spectra actions, including pain inflammation induction smooth...
The first amphibian skin antimicrobial peptide (AMP) to be identified was named bombinin, reflecting its origin from the of European yellow-bellied toad (Bombina variegata). Bombinins and their related peptides, bombinin Hs, were subsequently reported other bombinid toads. Molecular cloning bombinin-encoding cDNAs found that bombinins Hs coencoded on same precursor proteins. Here, we report molecular two novel a secretion-derived cDNA library B. variegata whose open-reading frames each...
The defensive skin secretions of many amphibians are a rich source bradykinins and bradykinin-related peptides (BRPs). Members this peptide group also common components reptile arthropod venoms due to their multiple biological functions that include induction pain, effects on smooth muscle types, lowering systemic blood pressure. While most BRPs bradykinin receptor agonists, some have curiously been found be exquisite antagonists, such as the maximakinin gene-related peptide, kinestatin—a...
Abstract Antimicrobial peptides (AMPs) are promising drug candidates to target multi-drug resistant bacteria. The rumen microbiome presents an underexplored resource for the discovery of novel microbial enzymes and metabolites, including AMPs. Using functional screening computational approaches, we identified 181 potentially AMPs from a bacterial metagenome. Here, show that three selected (Lynronne-1, 2 3) were effective against numerous pathogens, methicillin Staphylococcus aureus (MRSA)....