A5061788165- Hearing, Cochlea, Tinnitus, Genetics
- Antimicrobial Peptides and Activities
- Ear Surgery and Otitis Media
- Biochemical and Structural Characterization
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Head and Neck Anomalies
- Ear and Head Tumors
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- EEG and Brain-Computer Interfaces
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Amphibian and Reptile Biology
- Electrical and Bioimpedance Tomography
- Circular RNAs in diseases
- Advanced Glycation End Products research
- Curcumin's Biomedical Applications
- Congenital Ear and Nasal Anomalies
- Magnetic Field Sensors Techniques
- Facial Rejuvenation and Surgery Techniques
- RNA modifications and cancer
- Venomous Animal Envenomation and Studies
- Sleep and Wakefulness Research
Fudan University
2013-2025
Eye & ENT Hospital of Fudan University
2008-2025
Shanghai Medical Information Center
2020-2025
State Key Laboratory of Medical Neurobiology
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
China Medical University
2014-2022
Ministry of Education of the People's Republic of China
2020-2022
Huizhou Central People's Hospital
2021
Fourth People's Hospital of Taiyuan
2021
National Health and Family Planning Commission
2020
Background: Cochlear implantation is safe and effective in restoring hearing speech recognition abilities for individuals with severe to profound sensorineural loss. This prospective multicenter clinical trial was conducted evaluate the safety effectiveness of a novel cochlear implant (CI) system, LISTENT LCI-20PI device, post-lingually deafened individuals. Methods: The CI system implanted 70 6-68 (27.7 ± 14.0) years old. devices were evaluated during 1-year follow-up. Results: Electrically...
The main functions of the abundant polypeptide toxins present in scorpion venoms are debilitation arthropod prey or defence against predators. These effects achieved mainly through blocking an array ion channel types within membranes excitable cells. However, while these channel-blocking tightly-folded by multiple disulphide bridges between cysteine residues, there additional groups peptides that devoid residues. non-disulphide bridged subject much research interest, and among exhibit...
Chronic suppurative otitis media (CSOM) is mostly caused by bacterial infection of the middle ear and antibiotics are generally used empirically, which may lead to emergence resistant strains. The objective study assess bacteriological profile evaluate antibiotic susceptibility strains isolated in a tertiary care hospital Shanghai, China.This included 289 individuals with clinical diagnosis CSOM. Middle purulent discharge was obtained sterile swabs cultured for pathogens. microorganisms...
Non-small-cell lung cancer (NSCLC) is one of the most common causes cancer-related death. Our investigations show that miR-150 a typical microRNA overexpressed in human NSCLC. We characterized effects overexpression NSCLC cells and found down-regulation expression inhibited cell proliferation induced apoptosis vitro; additionally, up-regulation levels had opposite effect on tumor growth progression. Furthermore, we mechanism was associated with alterations BRI1-associated receptor kinase 1...
Antimicrobial peptides (AMPs) from the skin secretions of amphibians are now considered as a potential alternative to conventional antibiotics. Phylloseptins family AMPs identified in Phyllomedusinae tree frogs which exhibit highly conserved structural characteristics. This study examines structure-activity relationship newly discovered phylloseptin, Phylloseptin-PHa (PSPHa) Pithecopus hypochondrialis.PSPHa and modified analogs were produced by solid phase synthesis purified reverse-phase...
Amphibian skin secretions are remarkable sources of novel bioactive peptides. Among these, antimicrobial peptides have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer the prospect solving specific target-driven antibiotic resistance. Here, discovery defensive peptide is described from secretion African frog, Kassina senegalensis. Named kassinatuerin-3, it was identified through combination “shot-gun” cloning and MS/MS...
Sleep has been related to a variety of health outcomes. However, no association between sleep and asthenozoospermia reported. The aim this study is first investigate the relationship status risk. A case-control study, including 540 cases 579 controls, was performed from June 2020 December in infertility clinic Shengjing Hospital China Medical University. Data on were collected by Pittsburgh quality index questionnaires diagnosed based World Health Organization guidelines. Odds ratio (OR)...
Feleucins-BV1 and -BV2 are recently described prototypes of a novel antimicrobial non-apeptide (AMP) family identified in the skin secretion bombinid toad, Bombina variegata. They encoded on different precursors that also encode bombinin. Here we describe identification feleucin-BO1 (FLGLLGSLLamide) which is co-encoded with bombinin, named feleucin precursor-associated bombinin (FPA-bombinin-BO), from orientalis. Synthetic displayed activity against reference Gram-positive bacterium....
Bradykinin-related peptides (BRPs) are significant components of the defensive skin secretions many anuran amphibians, and these represent source most diverse spectrum such so far encountered in nature. Of families bioactive that have been identified from this source, BRPs uniquely appear to homologues counterparts specific distributions receptor targets within discrete vertebrate taxa, ranging fishes through mammals. Their broad spectra actions, including pain inflammation induction smooth...
In combined with neurofeedback, Motor Imagery (MI) based Brain-Computer Interface (BCI) has been an effective long-term treatment therapy for motor dysfunction caused by neurological injury in the brain (e.g., post-stroke hemiplegia). However, individual differences have led to variability single sessions of rehabilitation training. Research on impact short training functioning patterns can help evaluate and standardize duration this paper, we use electroencephalogram (EEG) signals explore...
Stroke patients often suffer from hand dysfunction or loss of tactile perception, which in turn interferes with rehabilitation. Tactile-enhanced multi-sensory feedback rehabilitation is an approach worth considering, but its effectiveness has not been well studied. By using functional near-infrared spectroscopy (fNIRS) to analyze the causal activity patterns sensorimotor cortex, present study aims investigate cortical hemodynamic effects training when stimulation applied, and provide a basis...
Dermaseptins are an antimicrobial peptide family widely identified from the skin secretions of phyllomeudusinae frogs. Here, we identify Dermaseptin-PC (DM-PC), secretion Phyllomedusa coelestis, and further investigate properties this peptide, a number rationally designed truncated derivatives. The 19-mer derived N-terminus exhibited similar potency when compared to parent but haemolytic effect was significantly decreased. Based on previous studies, charge hydrophobicity derivatives can...
Salmonella is a crucial food-borne pathogen causing food poisoning, leading to severe public health events. Here, we developed technique by integrating recombinase polymerase amplification with CRISPR-LbCas12a and employing two targets engineered crRNA for detection of (RPA-LbCas12a-TTECDS). Our findings revealed that this novel method rapidly detects trace in through fluorescence intensity provides template other methods. Further, was optimized increase sensitivity. Double were used enhance...
Aims and background Hypoxia inducible factor 1α (HIF-1α) vascular endothelial growth (VEGF) have been deemed as key in angiogenesis of lung cancer. The aim this study was to investigate diagnostic prognostic values HIF-1α VEGF patients with Methods From May 1, 2011, April 20, 2014, blood samples and/or pleural effusions were collected from 100 cancer, 18 tuberculosis, 47 community-acquired pneumonia, 29 healthy controls. pretreatment levels measured by enzyme-linked immunoassays. Patients...
Combining acoustic and electrical stimulation has been successfully used in patients with low-frequency residual hearing. Electrode insertion trauma, such as electrode translocation could result loss of hearing.The aim the study is to evaluate LCI-20PI array trauma intra-cochlear structures fresh human temporal bone specimens.The arrays were inserted into scalae tympani through round window membrane 10 cochleae from ten cadavers. The intracochlear was evaluated histologically by a scale 0-4:...
Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that has been associated with various metabolic diseases. However, such relationship among adolescents remains unclear. The purpose of this study was to clarify the between SFRP5 and components syndrome in Chinese adolescents.In cross-sectional study, we included total 684 aged 11-16 years old from Liaoyang city, Liaoning province, China. ELISA kits were implemented measure plasma high-sensitivity C-reactive...
The defensive skin secretions of amphibians continue to be an excellent source novel biologically-active peptides. Here we report the identification and pharmacological activity a C-terminally amided myotropic octapeptide from secretion African hyperoliid frog, Kassina senegalensis. 8-amino acid peptide has following primary structure: WMSLGWSL-amide molecular mass 978 Da. structure organisation biosynthetic precursor WL-8 amide was successfully deduced cloned secretion-derived cDNA....