A5101564006- Circular RNAs in diseases
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Plant Reproductive Biology
- Congenital Heart Disease Studies
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Atrial Fibrillation Management and Outcomes
- Plant nutrient uptake and metabolism
- Cellular transport and secretion
- Allergic Rhinitis and Sensitization
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Traditional Chinese Medicine Studies
- Photosynthetic Processes and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Plant responses to water stress
- Immunotherapy and Immune Responses
- Salivary Gland Disorders and Functions
- Bamboo properties and applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pleural and Pulmonary Diseases
Nanjing University of Chinese Medicine
2025
Capital Medical University
2010-2025
Beijing Anzhen Hospital
2010-2025
Southwest University of Science and Technology
2023-2024
Zhejiang University
2024
Sir Run Run Shaw Hospital
2024
Shanghai University of Traditional Chinese Medicine
2022-2023
Jilin Weather Modification Office
2023
Nanjing Maternity and Child Health Care Hospital
2020-2021
Nanjing Medical University
2008-2021
ABSTRACT Purpose Study aimed to assess fetal heart morphology and function in pregnancies with systemic lupus erythematosus (SLE) utilizing speckle tracking echocardiography (STE) evaluate indicators for predicting subclinical cardiac damage this population. Methods The study involved 99 SLE‐affected fetuses gestational age‐matched controls. parameters were calculated using STE (FetalHQ). Results absolute values of left ventricular (LV) global longitudinal strain (GLS), right (RV) GLS, LV...
<title>Abstract</title> Congenital heart disease (CHD) is the most common birth defect worldwide, which lacks effective early preventive methods due to limited knowledge of genetic defects involved in its development. Through analysis families with congenital (CHD), we identified a correlation between R755W variant platelet isoform phosphofructokinase 1 (PFKP) and myocardial hypoplasia. Furthermore, PFKP<sup>R754W/R754W</sup> PFKP knockout mice exhibited hypoplasia phenotype during embryonic...
J Oral Pathol Med (2012) 41 : 90–95 Background: lichen planus (OLP), which is a chronic inflammatory disease of the oral mucosa with unknown etiology, affects about 2% population. MicroRNAs are small non‐coding RNAs involved in normal processes such as development and differentiation well progression human diseases. The aim this study was to investigate expression miR‐21, miR‐125b, miR‐203 compare RNA levels their potential targets, tumor suppressor p53 its relative p63, both known be...
Non-small-cell lung cancer (NSCLC) is one of the most common causes cancer-related death. Our investigations show that miR-150 a typical microRNA overexpressed in human NSCLC. We characterized effects overexpression NSCLC cells and found down-regulation expression inhibited cell proliferation induced apoptosis vitro; additionally, up-regulation levels had opposite effect on tumor growth progression. Furthermore, we mechanism was associated with alterations BRI1-associated receptor kinase 1...
As the main component of plant cell walls, lignin can not only provide mechanical strength and physical defense for plants, but also be an important indicator affecting properties quality wood bamboo. Dendrocalamus farinosus is economic bamboo species both shoots timber in southwest China, with advantages fast growth, high yield slender fiber. Caffeoyl-coenzyme A-O-methyltransferase (CCoAOMT) a key rate-limiting enzyme biosynthesis pathway, little known about it D. farinosus. Here, total 17...
Both mammalian cells and Xenopus eggs possess activities for the joining of nonhomologous DNA ends, such may play a major role in double-strand break repair. In order to dissect biochemical processing breaks with oxidatively modified vectors containing various site-specific 3′-phosphoglycolate termini were constructed treated egg extracts. These rejoined by extracts at rates 30-100 times slower than comparable 3′-hydroxyl vectors. Vectors blunt or cohesive ends yielded single repair products...
1. Imiquimod, a synthetic Toll-like receptor (TLR) 7 ligand, has been shown to attenuate airway inflammation and hyperresponsiveness (AHR) in acute murine models of allergic asthma. In the present study, we investigated effect imiquimod on allergen-induced remodelling chronic experimental 2. Ovalbumin (OVA)-sensitized mice were chronically challenged with aerosolized OVA for 8 weeks. Some exposed an aerosol 0.15% daily during period challenge. Twenty-four hours after last challenge,...
Erbin has been shown to have significant effects on the development of solid tumors. However, little is known about its function and regulatory mechanism in hematological malignancies. The biological cell proliferation was measured vitro vivo. predicted target validated by dual-luciferase reporter assay rescue experiment. We found that overexpression could inhibit promote differentiation acute myeloid leukemia (AML) cells, whereas depletion enhance block AML cells Besides, miR-183-5p...
Abstract LBX2‐AS1 is a long non‐coding RNA that facilitates the development of gastrointestinal cancers and lung cancer, but its participation in ovarian cancer remained uninvestigated. Clinical data retrieved from TCGA database clinography 60 patients who received anti‐cancer treatment our facility were analysed. The overall cell growth, colony formation, migration, invasion, apoptosis tumour formation on nude mice cells evaluated before after lentiviral‐based knockdown. ENCORI platform was...
Communication systems within and between plant cells involve the transfer of ions molecules compartments, are essential for development responses to biotic abiotic stresses. This in turn requires regulated movement fusion membrane with their associated cargo. Recent advances genomics has provided new resources which investigate evolutionary relationships proteins across species. Members soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) known play important roles...
Sucrose is the main transported form of photosynthetic products. transporter (SUT) participates in translocation sucrose from source to sink, which important for growth and development plants. Dendrocalamus farinosus an economic crop southwestern China because its high rate, fiber content, dual usage food timber, but mechanism transportation D. unclear. In this study, a total 12 SUT genes were determined by whole-genome identification. DfSUT2, DfSUT7, DfSUT11 homologs rice OsSUT2, while...
Although numerous long non-coding RNAs (lncRNAs) have been identified to be important in human cancer, their potential regulatory roles epithelial tumorigenesis and tumor progression ovarian cancer remain unclear. The purpose of the present study was investigate lncRNAs that were differentially expressed (DE) explore functions. lncRNA profiles five pairs tissues adjacent normal described using microarrays. results microarray analysis revealed 672 upregulated 549 downregulated (fold-change...
The plant hormone auxin and its directional intercellular transport play a major role in diverse aspects of growth development. establishment gradients requires the asymmetric distribution members efflux carrier PIN-FORMED (PIN) protein family to plasma membrane. An endocytic pathway regulates recycling PIN proteins between membrane endosomes, providing mechanism for dynamic localisation. N-Ethylmaleimide-sensitive factor adaptor receptors (SNAP receptors, SNAREs) mediate fusion vesicles...
Previous work with Xenopus egg extracts suggested that a wortmannin-sensitive protein phosphorylation event precedes both the removal of modified termini from DNA double-strand break ends and joining unmodified ends. To assess possible role DNA-dependent kinase in effecting this phosphorylation, end-joining DNA-stimulated were examined presence various inhibitors. Linear but not supercoiled stimulated several endogenous proteins extracts, including species approximately 48, 87, 96 kDa. This...
Molecular therapies that target genetic abnormalities in leukemic cells and their affected signaling pathways have been emerging pediatric acute lymphoblastic leukemia (ALL). Glycogen synthase kinase-3β (GSK-3β) has recently found to positively regulate the activity of nuclear factor-κB (NF-κB). Here, we investigated relationship between GSK-3β inhibition NF-κB apoptosis primary obtained from 39 newly diagnosed ALL children China.Bone marrow mononuclear (BMMC) were isolated by density...
Astragaloside IV (AS-IV) has been noted for its reduction of eosinophilic airway inflammation in a murine model chronic asthma. To gain better understanding the mechanisms involved this anti-inflammatory phenomenon, effect AS-IV on human blood eosinophils was studied vitro. Eosinophils were isolated from patients with mild atopic asthma, preincubated 1 h and stimulated presence or absence house dust mite allergen Dermatophagoides pteronyssinus (Der p) 4 h. The survival at 48 investigated...
MicroRNAs (miRNAs) are a class of endogenous, small, non-coding RNAs that regulate gene expression by targeting mRNAs and inhibiting via translation repression or RNA degradation. Emerging evidence indicates miRNAs play crucial role in the pathogenesis human diseases, including tumor development. We profiled miRNA between mature ovarian teratoma samples matched normal tissues using microarrays, followed validation with quantitative RT-PCR (qRT-PCR). The most highly expressed were...