A5022788866- COVID-19 Clinical Research Studies
- Parasites and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Biomarkers in Disease Prognosis
- Parasite Biology and Host Interactions
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Neonatal Health and Biochemistry
- Adipokines, Inflammation, and Metabolic Diseases
- Glutathione Transferases and Polymorphisms
- Long-Term Effects of COVID-19
- Supercapacitor Materials and Fabrication
- Dermatology and Skin Diseases
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Influenza Virus Research Studies
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Virology and Viral Diseases
- Parasitic Diseases Research and Treatment
- interferon and immune responses
Novavax (United States)
2023-2024
Soochow University
2023
GlaxoSmithKline (United States)
2020
Air Force General Hospital PLA
2020
George Washington University
2009-2012
Sabin Vaccine Institute
2010
81th Hospital of PLA
2009
Washington University Medical Center
2009
Daping Hospital
1999
Army Medical University
1999
Monovalent SARS-CoV-2 Prototype (Wuhan-Hu-1) and bivalent (Prototype + BA.4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity highlighted by lower neutralizing antibody responses against Omicron XBB sub-variants. The reduction humoral due to the rapid evolution has signaled need for an update vaccine composition. A strain change all authorized/approved monovalent composition with subvariant XBB.1.5 been supported WHO, EMA, FDA. Here, we demonstrate that...
Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival represent potential targets vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na-GST-2, Na-GST-3, respectively) were isolated cDNA based on their sequence similarity to Ac-GST-1, dog Ancylostoma caninum. The open reading frames of three N. GSTs contain 206 amino acids with 51% 69% identity between other Ac-GST-1....
Hookworms digest hemoglobin from erythrocytes via a proteolytic cascade that begins with the aspartic protease, APR-1. Ac-APR-1 dog hookworm, Ancylostoma caninum, protects dogs against hookworm infection antibodies neutralize enzymatic activity and interrupt blood-feeding. Toward developing human vaccine, we expressed both wild-type (Na-APR-1wt) mutant (Na-APR-1mut—mutagenesis of catalytic acids) forms Na-APR-1 Necator americanus. Refolded Na-APR-1wt was catalytically active, Na-APR-1mut...
Toll-like receptor 9 (TLR9) has been shown to have a significant role in cancer. MicroRNAs (miRNAs), group of small non-coding RNAs that fine tune translation multiple target mRNAs, are involved the development and progression human cancers. The present study was undertaken determine roles TLR9 on lung cancer whether miR-26a is TLR9‑mediated growth migration. models were elicited by injecting cells into left ventricle. expression tissues obtained from patients increased. ligand...
Na-ASP-2 is a major protein secreted by infective third-stage larvae (L3) of the human hookworm Necator americanus upon host entry. It was chosen as lead vaccine candidate for its ability to elicit protective immune responses. However, clinical development this antigen recombinant halted because it caused allergic reactions among some volunteers previously infected with N. americanus. To prevent IgE-mediated induced but keep immunogenicity antigen, we designed and tested genetically...
Abstract Monovalent SARS-CoV-2 Prototype (Wuhan-Hu-1) and bivalent (Prototype + BA.4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity highlighted by lower neutralizing antibody responses against Omicron XBB sub-variants. The reduction humoral due to the rapid evolution has signaled need for an update vaccine composition. A strain change all authorized/approved monovalent composition with subvariant XBB.1.5 been supported WHO, EMA, FDA. Here, we demonstrate that...
Astragaloside IV (AS-IV) has been noted for its reduction of eosinophilic airway inflammation in a murine model chronic asthma. To gain better understanding the mechanisms involved this anti-inflammatory phenomenon, effect AS-IV on human blood eosinophils was studied vitro. Eosinophils were isolated from patients with mild atopic asthma, preincubated 1 h and stimulated presence or absence house dust mite allergen Dermatophagoides pteronyssinus (Der p) 4 h. The survival at 48 investigated...
Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using human neutralizing (nAb) RSB1. The crystal structure PreF complexed with RSB1 reveals conformational, pre-fusion specific site V epitope unique cross-protomer binding mechanism. We identify shared features between...
Abstract Objective The aim of this study was to identify early warning signs for severe novel coronavirus-infected pneumonia (COVID-19). Methods We retrospectively analyzed the clinical data 90 patients with COVID-19 from Guanggu District Hubei Women and Children Medical Healthcare Center comprising 60 mild cases 30 cases. demographic data, underlying diseases, manifestations laboratory blood test results were compared between two groups. cutoff values determined by receiver operating...
Abstract Objective The aim of this study was to identify early warning signs for severe coronavirus disease 2019 (COVID-19). Methods We retrospectively analysed the clinical data 90 patients with COVID-19 from Guanggu District Hubei Women and Children Medical Healthcare Center, comprising 60 mild cases 30 cases. demographic data, underlying diseases, manifestations laboratory blood test results were compared between two groups. cutoff values determined by receiver operating characteristic...
With the recent rise in cases of highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b infection humans and animals, there is an associated increase risk human-to-human transmission. In this study, we characterize recombinant A/American Wigeon/South Carolina/22/000345-001/2021 (A/AW/SC/2021) vaccine. Purified A/AW/SC/2021 HA trimers upon formulation with Matrix-M™ adjuvant, saponin-cholesterol-phospholipid icosahedral particles, non-covalently anchored to vertices Matrix-M forming...
Objective To explore the change of serum interleukin-8(IL-8) and tumor necrosis factor-α (TNF-α) patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) accompanied anxiety-depressive disorder. Methods Thirty-five 421 male 14 female) in hospital diagnosed AECOPD during March 1999 2004 were randomly divided into two groups, disorder group no group. Observation time was weeks. Observed symptoms included cough, expectoration, asthma, dyspnea, chest distress, anxiety...
Abstract Objective The aim of this study was to identify early warning signs for severe novel coronavirus-infected pneumonia (COVID-19). Methods We retrospectively analyzed the clinical data 90 patients with COVID-19 at Guanggu District Hubei Women and Children Medical Healthcare Center comprising 60 mild cases 30 cases. demographic data, underlying diseases, manifestations laboratory blood test results were compared between two groups. Logistic regression analysis performed independent risk...
Two major tRNA binding proteins were obtained by biochemical method from yeast crude extracts of total membrane proteins. They further confirmed to be specific-binding gel mobility shift assay. N-terminal sequence assays showed that they glyceraldehyde-3-phosphate dehydranase (GAPDH) and 3-phosphate glycerate kinase (PGK1), respectively. Keywords: (GAPDH), RNA polymerase III