A5080261111- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Mosquito-borne diseases and control
- Education Methods and Technologies
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Protein Structure and Dynamics
- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Impact on Reproduction
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
- Animal Disease Management and Epidemiology
- Diet, Metabolism, and Disease
- Aquaculture disease management and microbiota
Novavax (United States)
2023
National Institute of Allergy and Infectious Diseases
2022
National Institutes of Health
2022
Emory University
2016-2022
Center for Surveillance, Epidemiology, and Laboratory Services
2019
Centers for Disease Control and Prevention
2014-2018
National Center for Immunization and Respiratory Diseases
2017
KU Leuven
2014
National Wildlife Health Center
2014
United States Geological Survey
2014
Monovalent SARS-CoV-2 Prototype (Wuhan-Hu-1) and bivalent (Prototype + BA.4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity highlighted by lower neutralizing antibody responses against Omicron XBB sub-variants. The reduction humoral due to the rapid evolution has signaled need for an update vaccine composition. A strain change all authorized/approved monovalent composition with subvariant XBB.1.5 been supported WHO, EMA, FDA. Here, we demonstrate that...
Summary SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to antibody neutralization following immunization with ancestral spike-matched vaccines. It unclear whether boosting Omicron-specific vaccines would enhance immunity protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 4 were boosted week 41 or mRNA-Omicron. Neutralizing titers against D614G 4760 270 reciprocal ID 50 6 (peak) (pre-boost), respectively, 320 110 for Omicron. Two after boost,...
Influenza A viruses can bind sialic acid-terminating glycan receptors, and species specificity is often correlated with acid linkage avian strains recognizing α2,3-linked sialylated glycans mammalian preferring α2,6-linked glycans. These paradigms derive primarily from studies involving erythrocyte agglutination, binding to synthetic receptor analogs or undefined surface markers on cells tissues. Here, we present the first examination of N-glycome human lung for identifying natural receptors...
We characterized the acute B cell response in adults with cholera by analyzing repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. found that cholera-induced responses were high levels somatic hypermutation large clonal expansions. A majority expansions targeted toxin (CT) or lipopolysaccharide (LPS). Using a novel proteomics approach, we able to identify sialidase as another major antigen antibody Vibrio...
H3N2 strains of influenza A virus emerged in humans 1968 and have continued to circulate, evolving response human immune pressure. During this process "antigenic drift," viruses progressively lost the ability agglutinate erythrocytes various species replicate efficiently under established conditions for amplifying clinical isolates generating vaccine candidates. We determined glycome profiles chicken guinea pig gain insights into reduced agglutination properties displayed by drifted show...
Abstract Monovalent SARS-CoV-2 Prototype (Wuhan-Hu-1) and bivalent (Prototype + BA.4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity highlighted by lower neutralizing antibody responses against Omicron XBB sub-variants. The reduction humoral due to the rapid evolution has signaled need for an update vaccine composition. A strain change all authorized/approved monovalent composition with subvariant XBB.1.5 been supported WHO, EMA, FDA. Here, we demonstrate that...
Background Detections of influenza A subtype‐specific antibody responses are often complicated by the presence cross‐reactive antibodies. We developed two novel multiplex platforms for detection. The multiplexed magnetic fluorescence microsphere immunoassay (MAGPIX) is a high‐throughput laboratory‐based assay. Chembio Dual Path Platform (DPP) portable and rapid test that could be used in field. Methods Twelve recombinant globular head domain hemagglutinin (GH HA1) antigens from A(H1N1)pdm09...
Summary Patients with severe aplastic anaemia (SAA) are often not vaccinated against viruses due to concerns of ineffective protective antibody response and potential for pathogenic global immune system activation, leading relapse. We evaluated the impact COVID‐19 vaccination on haematological indices disease status characterized humoural cellular responses in 50 SAA patients, who were previously treated immunosuppressive therapy (IST). There was no significant difference haemoglobin ( p =...
Study Objective: The 2009 H1N1 pandemic (H1N1pdm) virus has been associated with high rates of asymptomatic infections. Existing influenza infection control policies do not address potential transmission through exposure to infected individuals in health care settings. We conducted a seroprevalence study H1N1pdm determine whether workers (HCWs) the emergency department showed increased evidence during first wave than that previously reported adults community. Methods: Blood samples and...
Many broadly neutralizing antibodies (bnAbs) bind to conserved areas of the hemagglutinin (HA) stalk region and can inhibit low pH induced HA conformational changes necessary for viral membrane fusion activity. We developed evaluated a high-throughput virus-free cell-free ELISA based Conformational Change Inhibition Antibody Detection Assay (HCCIA) complementary proteinase susceptibility assay. Human serum samples (n = 150) were tested by HCCIA using H3 recombinant HA. Optical density (OD)...