Cuiping Liu
A5052629527- HIV Research and Treatment
- Thyroid Disorders and Treatments
- Structural Load-Bearing Analysis
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Structural Behavior of Reinforced Concrete
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Structural Response to Dynamic Loads
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Advanced Photocatalysis Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Streptococcal Infections and Treatments
- Birth, Development, and Health
- Recycling and Waste Management Techniques
- Extraction and Separation Processes
- Hepatitis B Virus Studies
- Parathyroid Disorders and Treatments
- Immunotherapy and Immune Responses
National Institute of Allergy and Infectious Diseases
2020-2024
Shandong First Medical University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Nanjing Drum Tower Hospital
2023-2024
National Institutes of Health
2020-2024
Nanjing University
2023-2024
Sixth Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Institut de Recherche Vaccinale
2024
Second Affiliated Hospital of Soochow University
2024
Treatment of HIV infection with either antiretroviral (ARV) therapy or neutralizing monoclonal antibodies (NAbs) leads to a reduction in plasma virus. Both ARVs and NAbs prevent new rounds viral infection, but may have the additional capacity accelerate loss virus-infected cells through Fc gamma receptor (FcγR)-mediated effector functions, which should affect kinetics plasma-virus decline. Here, we formally test role function vivo by comparing rate timing clearance response single-dose...
Summary SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to antibody neutralization following immunization with ancestral spike-matched vaccines. It unclear whether boosting Omicron-specific vaccines would enhance immunity protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 4 were boosted week 41 or mRNA-Omicron. Neutralizing titers against D614G 4760 270 reciprocal ID 50 6 (peak) (pre-boost), respectively, 320 110 for Omicron. Two after boost,...
The fusion peptide (FP) on the HIV-1 envelope (Env) trimer can be targeted by broadly neutralizing antibodies (bNAbs). Here, we evaluated ability of a human FP-directed bNAb, VRC34.01, along with two vaccine-elicited anti-FP rhesus macaque mAbs, DFPH-a.15 and DF1W-a.01, to protect against simian-HIV (SHIV) BG505 challenge. VRC34.01 neutralized SHIV 50% inhibitory concentration (IC 50 ) 0.58 μg/ml, whereas DF1W-a.01 were 4- or 30-fold less potent, respectively. was infused into four macaques...
Objective This study aimed to assess risk factors for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) after immunoprophylaxis. Methods Risk MTCT were assessed using a multivariate logistic regression model. Patients We enrolled 256 mother-child pairs with positive maternal surface antigens (HBsAg) between January 2010 and June 2013. All children received passive-active immunization birth. The tested HBsAg at birth 6-12 months and/or 1-3 years age. Results Among children, 10...
Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads emergence escape variants, suggesting a potential benefit combination bNAb therapy. Here, trispecific reduces viremia 100- 1000-fold in viremic SHIV-infected macaques. After discontinuation, rebounds transiently and returns low levels, through CD8-mediated immune control. These viruses remain sensitive antibody, despite loss...
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab Fc domains, respectively. So far, bNAbs with enhanced in vitro only been tested NHPs during chronic simian-HIV (SHIV) infection. Here, we investigate effects administering acute SHIV AD8-EO infection either wild-type (WT) or carrying S239D/I332E/A330L (DEL) mutation, which increases binding to FcγRs. Emergence plasma lymph...
In recent years, the rapid development of new energy vehicle industry has led to an increase in production used lithium-ion batteries. The recycling waste batteries is expected alleviate shortage valuable metals battery materials. electrode material adhered collector by a viscous organic binder such as PVDF. A key step separate anode and aluminum foil from lithium obtain materials rich metals. Compared with chemical dissolution decomposition, pyrolysis pretreatment simple feasible method. By...
BACKGROUNDBroadly neutralizing monoclonal antibodies (bNAbs) represent a promising strategy for HIV-1 immunoprophylaxis and treatment. 10E8VLS VRC07-523LS are bNAbs that target the highly conserved membrane-proximal external region (MPER) CD4-binding site of viral envelope glycoprotein, respectively.METHODSIn this phase 1, open-label trial, we evaluated safety pharmacokinetics 5 mg/kg administered alone, or concurrently with VRC07-523LS, via s.c. injection to healthy non-HIV-infected...
Human B cell immunity to the influenza hemagglutinin (HA) stem region, a universal vaccine target, is often stereotyped and immunogenetically restricted, posing challenges for study outside humans. Here, we show that macaques vaccinated with HA immunogen elicit human-like public lineages targeting two major conserved sites of vulnerability, central anchor epitopes. Central antibodies were predominantly derived from VH1-138, macaque homolog human VH1-69, VH-gene preferentially used in broadly...
Antibodies mediate protection against a wide range of pathogens through binding and neutralizing the pathogen or Fc-mediated effector functions. Human monoclonal antibodies (mAbs) CIS43LS L9LS show high-affinity targeting distinct regions on Plasmodium falciparum circumsporozoite protein (PfCSP) are highly effective in preventing malaria humans. However, role FcγR by these mAbs has not been determined. Here, we assessed several Fc variants for infection with transgenic berghei parasite...
Antibody CAP256-VRC26.25 targets the second hypervariable region (V2) at apex of HIV envelope (Env) trimer with extraordinary neutralization potency, although less than optimal breadth. To improve breadth, we linked light chain CAP256V2LS, an optimized version currently under clinical evaluation, to llama nanobody J3, which has broad CD4-binding site-directed neutralization. The J3-linked bispecific antibody exhibited improved breadth and potency over both J3 indicative synergistic cryo-EM...
Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV-1, but their potency breadth less than optimal. This study describes the immunization of a llama with prefusion-stabilized HIV-1 envelope (Env) trimer, BG505 DS-SOSIP, identification improvement potent nanobodies recognizing CD4-binding site (CD4bs) vulnerability. Two vaccine-elicited CD4bs-targeting nanobodies, G36 R27, when engineered into triple tandem format IgG2a-hinge region human...
The aim of the study was to investigate role endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression and its mechanism. mechanical stretch downregulated SO2/AAT1 increased I III protein expression. Importantly, AAT1 overexpression blocked increase expression, transforming growth factor-β1 (TGF- β1) phosphorylation Smad2/3 induced by stretch, but knockdown mimicked TGF- β1 stretch. Mechanistically, SB431542, a...
Ionic conductive gels are promising soft conductors for stretchable and flexible electronics. Unfortunately, the basic requirements an ideal ionic gel, including environmental chemical stability as well low toxicity cost do not usually coincide in one material. Here we report gel containing deep eutectic solvents (DES), which specialized liquids composed of propylene glycol (PG, hydrogen bonding donor) various salts. In experiments, DES-gel loses about 10% original weight dry air (5– 9%...