A5059592201- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Alzheimer's disease research and treatments
- Pomegranate: compositions and health benefits
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- IL-33, ST2, and ILC Pathways
- Cancer, Lipids, and Metabolism
- Parasite Biology and Host Interactions
- Lipid metabolism and disorders
- Heart Failure Treatment and Management
- MicroRNA in disease regulation
- Antioxidant Activity and Oxidative Stress
- Sesame and Sesamin Research
Shanghai Jiao Tong University
2015-2025
Shanghai First People's Hospital
2015-2025
National Institute on Aging
2019-2024
Binzhou University
2022
Binzhou Medical University
2022
Wuhan University
2019-2021
Nanjing Medical University
2008-2020
Second Hospital of Anhui Medical University
2020
Anhui Medical University
2020
Southern Medical University
2018-2020
Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear. AD mouse brains showed lower nicotinamide adenine dinucleotide (NAD + ) levels alterations inflammation. Treatment mice with NR reduced neuroinflammation, attenuated DNA damage, prevented cellular senescence. We present evidence that beneficial effects riboside (NR) are, part, through a cyclic GMP-AMP synthase...
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result hypertrophy and subsequent heart failure, associated pyroptosis, the pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis remains unknown. Our study revealed that mir-30d expression was substantially increased streptozotocin (STZ)-induced rats...
Compromised autophagy, including impaired mitophagy and lysosomal function, plays pivotal roles in Alzheimer's disease (AD). Urolithin A (UA) is a gut microbial metabolite of ellagic acid that stimulates mitophagy. The effects UA's long-term treatment AD mechanisms action are unknown.
This study was performed to investigate whether intensive antihypertensive treatment with achieved blood pressure ( BP ) ≤140/90 mm Hg, as compared standard ≤150/90 could further improve cardiovascular outcomes in Chinese hypertensive patients older than 70 years. A total of 724 participants were randomly assigned or treatment. After a mean follow‐up 4 years, the 135.7/76.2 Hg group and 149.7/82.1 group. The visit‐to‐visit variability systolic diastolic lower that Intensive treatment,...
Alzheimer's Disease (AD) is the most common neurodegenerative disorder in elderly. Beta-amyloid (Aβ) peptide accumulation considered as a primary cause of AD pathogenesis, with defective autophagy patients' brains. Enhanced autophagic activity has been reported to promote Aβ clearance vitro and vivo models. Meanwhile, there growing evidence that estrogen receptor β (ERβ) viable therapeutic target can ameliorate pathological features associated AD. Very little known about detailed molecular...
Aims . We aimed to investigate whether LCZ696 protects against pathological cardiac hypertrophy by regulating the Sirt3/MnSOD pathway. Methods In vivo , we established a transverse aortic constriction animal model establish pressure overload-induced heart failure. Subsequently, mice were given oral gavage for 4 weeks. After that, underwent transthoracic echocardiography before they sacrificed. vitro introduced phenylephrine prime neonatal rat cardiomyocytes and small-interfering RNA knock...
Abstract Flubendazole, FDA-approved anthelmintic, has been widely used in treating testinal parasites. In the recent years, Flubendazole reported to exert anticancer activities. On other hand, little was known about effects of on gliomas. Here we demonstrated a novel effect flubendazole glioma cells. We found that inhibited cell proliferation and promoted apoptosis lines vitro, suppressed tumor growth xenograft models by intraperitoneal injection. However, might have no influence migration....
Dysfunction of autophagic degradation machinery causes tumorigenesis, including colorectal cancer (CRC).Overexpression CyclinD1 in CRC has been reported.Recent evidence also suggests that ERβ deficiency is related to the pathogenesis CRC.Very little known, however, about detailed molecular mechanisms underlying relationship among ERβ, autophagy, and CRC.Here, results showed played an anti-proliferation role HCT116 through impairing cell cycle but not apoptosis.Additionally, accumulation was...
Atrial fibrosis serves as an important contributor to atrial fibrillation (AF). Recent data have suggested that microRNA-30c (miR-30c) is involved in fibrotic remodelling and cancer development, but the specific role of miR-30c remains unclear. The purpose this study was investigate its underlying mechanisms through vivo vitro experiments. Our results indicate significantly down-regulated rat abdominal aortic constriction (AAC) model cellular induced by transforming growth factor-β1...
Premature ventricular complex (PVC) with narrow QRS duration originating from proximal left anterior fascicle (LAF) is challenging for ablation. This study was performed to evaluate the safety and feasibility of ablation right coronary cusp (RCC) LAF-PVC investigate this PVC's characteristics.Mapping at RCC ventricle ECG analysis were in 20 patients LAF-PVC.The earliest activation site (EAS), Purkinje potential during both PVC sinus rhythm, localized LAF 8 (proximal group) nonproximal 12...
Alzheimer's disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and microbiota-host interactions in aging neurodegeneration. Our previous works have demonstrated that supplementation with nicotinamide adenine dinucleotide (NAD+) precursor, riboside (NR), reduced brain features of AD, including neuroinflammation, deoxyribonucleic acid (DNA) damage, synaptic dysfunction, cognitive impairment. However, impact NR administration...
High expression of the epidermal growth factor receptor (EGFR) has been implicated in development pancreatic cancer. Gefitinib is an orally active and selective EGFR-TKI (EGFR-tyrosine kinase inhibitor) that blocks signal transduction pathways responsible for proliferation survival cancer cells, other host-dependent processes promoting growth. This study investigated anticancer effect gefitinib on human cells molecular mechanism involved. We first evaluated cell with MTT assay results...
Emerging evidences indicate that SCN10A/NaV1.8 is associated with cardiac conduction and atrial fibrillation, but the exact role of NaV1.8 in electrophysiology remains poorly understood. The present study was designed to investigate effects blocking channels ganglionated plexi (GP) on modulating fibrillation inducibility canine model.Thirteen mongrel dogs were randomly enrolled. Right cervical vagus nerve stimulation (VNS) applied determine its sinus rate, ventricular rate during PR...
Background: Sacubitril/valsartan reduces cardiovascular death and hospitalizations for heart failure (HF). However, decision-makers need to determine whether its benefits are worth the additional costs, given low-cost generic status of traditional standard care.Aims: To evaluate cost-effectiveness sacubitril/valsartan compared enalapril in patients with HF reduced ejection fraction, from Singapore healthcare payer perspective.Methods: A Markov model was developed project clinical economic...
Background: Myocardial infarction (MI) is a leading cause of disease with high morbidity and mortality worldwide. Recent studies have revealed that long non-coding RNAs (lncRNAs) are involved in heart pathogenesis. This study aimed to investigate the effect molecular basis THRIL on hypoxia-injured H9C2 cells. Methods: THRIL, miR-99a Brahma-related gene 1 (Brg1) expressions cells were altered by transient transfections. The subjected hypoxia for 4 h, then levels Brg1 investigated. Cell...
Abstract Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types. However, the role FoxO1 DEX-induced pancreatic β-cell dysfunction has not been fully understood. Therefore, this study, we investigated whether could mediate possible underlying mechanisms line RINm5F cells primary rat islet. We found that DEX markedly mRNA protein expression decreased phosphorylation through Akt...