A5103162332- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Peptidase Inhibition and Analysis
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Calcium signaling and nucleotide metabolism
Harbin Medical University
2014
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result hypertrophy and subsequent heart failure, associated pyroptosis, the pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis remains unknown. Our study revealed that mir-30d expression was substantially increased streptozotocin (STZ)-induced rats...
Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. has been proven to affect series pathways and exert proapoptotic effect cardiomyocytes. However, whether it is able regulate autophagy remains largely unknown. Here, we report that prolonged oxidative stress-induced activation calcineurin contributes attenuation adaptive AMP-activated protein kinase (AMPK) inhibits Primary cardiomyocytes exhibited rapid formation autophagosomes,...
Abstract Ovarian cancer is one of the most common malignancies in women. Tripartite motif-containing protein 22 (TRIM22) plays an important role initiation and progression malignant tumors. Similarly, transcription factor 4 (TCF4) essential involved many However, it still unclear whether TRIM22 can affect TCF4 ovarian cancer. Therefore, this study aims to investigate mechanism related mRNA levels were analyzed samples from clinical cell lines. The effects knockdown overexpression on...