A5066664173- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Aging and Gerontology Research
- RNA modifications and cancer
- Tryptophan and brain disorders
- Essential Oils and Antimicrobial Activity
- Reproductive Biology and Fertility
- Inflammasome and immune disorders
- Wound Healing and Treatments
- Glioma Diagnosis and Treatment
- Calcium signaling and nucleotide metabolism
- Phytochemicals and Antioxidant Activities
- Intergenerational Family Dynamics and Caregiving
- Mesenchymal stem cell research
- Higher Education Learning Practices
- Alzheimer's disease research and treatments
- Interpreting and Communication in Healthcare
- Cancer-related molecular mechanisms research
- Sulfur Compounds in Biology
- Gout, Hyperuricemia, Uric Acid
- Medicinal Plants and Neuroprotection
- Ginger and Zingiberaceae research
- Parkinson's Disease Mechanisms and Treatments
Wenzhou Medical University
2023-2025
First Hospital of Shijiazhuang
2025
Harbin Medical University
2000-2024
Third Affiliated Hospital of Harbin Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Washington Center
2000
Bellevue Hospital Center
2000
Université de Montréal
2000
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result hypertrophy and subsequent heart failure, associated pyroptosis, the pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis remains unknown. Our study revealed that mir-30d expression was substantially increased streptozotocin (STZ)-induced rats...
Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. has been proven to affect series pathways and exert proapoptotic effect cardiomyocytes. However, whether it is able regulate autophagy remains largely unknown. Here, we report that prolonged oxidative stress-induced activation calcineurin contributes attenuation adaptive AMP-activated protein kinase (AMPK) inhibits Primary cardiomyocytes exhibited rapid formation autophagosomes,...
Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. However, the low drug delivery efficiency caused by lysosomal sequestration and activation of protective autophagy severely restricts efficacy. Herein, in situ transformable nanoparticle named KCKT is developed to promote escape directly mitochondria while blocking autophagy. exhibits acid responsiveness for precise self-assembly into nanofibers within lysosomes cancer cells. The massive accumulation...
The present work was to investigate the effects of flavonoid extracts from celery on oxidative stress induced by dichlorvos (DIC) in male Wistar rats maintained a normal diet. were given DIC through intragastric administration dose 7.2 mg/kg·body weight (bw)/day and additionally added 5% diet for 4 weeks continuously. activities superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST) content malondialdehyde (MDA) livers measured at end...
Glioblastoma is a highly aggressive and invasive brain tumor with an extremely poor prognosis. The aims of the present study are to investigate pathogenesis glioblastoma identify potential therapeutic targets. We performed systematic analysis gene expression data from multiple datasets, including GEO TCGA, hub genes pathways associated progression. Bioinformatics tools were utilized analyze differential expression, pathway enrichment survival Both in vitro vivo functional experiments...