A5100771858- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Tryptophan and brain disorders
- Lipid Membrane Structure and Behavior
- Photosynthetic Processes and Mechanisms
- Reproductive System and Pregnancy
- Plant Reproductive Biology
- Animal Genetics and Reproduction
- Autophagy in Disease and Therapy
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Clostridium difficile and Clostridium perfringens research
- Insect and Pesticide Research
- vaccines and immunoinformatics approaches
- Cancer Mechanisms and Therapy
- Study of Mite Species
- Wnt/β-catenin signaling in development and cancer
Southern Medical University
2022-2025
Guangzhou Medical University
2021-2024
Universidade de São Paulo
2024
Tsinghua University
2013-2023
ShenZhen People’s Hospital
2020-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022
Shanghai University of Traditional Chinese Medicine
2022
Qiqihar Medical University
2022
University of South China
2018-2020
Weatherford College
2020
Complement is a component of natural immunity. Its regulation needed to protect tissues from inflammation, but mice with disrupted gene for the complement regulator decay accelerating factor were normal. Mice that deficient in another murine regulator, Crry, generated investigate its role vivo. Survival Crry −/− embryos was compromised because deposition and concomitant placenta inflammation. activation at fetomaternal interface caused fetal loss breeding C3 rescued lethality. Thus, critical...
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result hypertrophy and subsequent heart failure, associated pyroptosis, the pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis remains unknown. Our study revealed that mir-30d expression was substantially increased streptozotocin (STZ)-induced rats...
Two mechanisms could account for the impaired humoral immune response found in Cr2-/- mice. The absence of complement receptors 1 and 2 (CR1, CR2) on B cells affect their activation. Alternatively, Ag trapping by follicular dendritic (FDC) cell maturation into Ig-secreting or memory cells. To compare roles CR1 CR2 vs FDC this abnormal response, bone marrow (BM) chimeric mice were generated immunized with specific T-dependent Ags. primary secondary Ab was measured. Cr2+/+ animals...
Abstract The male sterility of thermosensitive genic sterile (TGMS) lines wheat (Triticum aestivum) is strictly controlled by temperature. early phase anther development especially susceptible to cold stress. MicroRNAs (miRNAs) play an important role in plant and responses environmental In this study, deep sequencing small RNA (smRNA) libraries obtained from spike tissues the TGMS line under control conditions identified a total 78 unique miRNA sequences 30 families trans-acting interfering...
Abstract Previous studies have developed vascularized tumor spheroid models to demonstrate the impact of intravascular flow on progression and treatment. However, these not been widely adopted so vascularization spheroids in vitro is generally lower than tissues vivo. To improve level, a new strategy introduced form by adding fibroblasts (FBs) sequentially pre‐formed this method with cell lines from kidney, lung, ovary cancer. Tumor made higher FB densities periphery spheroid, which tend...
Protective antibody responses to vaccination or infection depend on affinity maturation, a process by which high-affinity germinal center (GC) B cells are selected the basis of their ability bind, gather, and present antigen T follicular helper (Tfh) cells. Here, we show that human GC have intrinsically higher-affinity thresholds for both cell receptor (BCR) signaling gathering as compared with naïve these functions mediated distinct cellular structures pathways ultimately lead affinity- Tfh...
Osimertinib, a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the preferred treatment for EGFR-mutated lung cancer. However, acquired resistance inevitably develops. While non-coding RNAs have been implicated in cancer through various functions, molecular mechanisms responsible osimertinib remain incompletely elucidated. RNA-sequencing technology was employed to determine differentially expressed lncRNAs (DE-lncRNAs) and mRNAs (DE-mRNAs) between...
Abstract Cr2 −/− mice have an impairment in humoral immunity, as shown by the decrease Ab titers against T cell-dependent Ags and abnormalities germinal center formation. Germinal centers are present, but they decreased size number, indicating problems their development. In this study, we investigated whether abnormality development is associated with establishment of optimal affinity maturation generation memory B cells, processes closely related to reaction. We immunized Cr2−/− animals...
B lymphocytes use cell receptors (BCRs) to sense the chemical and physical features of antigens. The activation isotype-switched IgG-BCR by mechanical force exhibits a distinct sensitivity threshold in comparison with IgM-BCR. However, molecular mechanisms governing these differences remain be identified. In this study, we report that low is highly dependent on tethering cytoplasmic tail heavy chain (IgG-tail) plasma membrane. Mechanistically, show positively charged residues IgG-tail play...
FcγRIIB functions to suppress the activation of immune cells. A single-nucleotide polymorphism in transmembrane (TM) domain FcγRIIB, FcγRIIB-T232, is associated with lupus. In this study, we investigated pathogenic mechanism FcγRIIB-T232 at both functional and structural levels. Our results showed that exhibited significantly reduced lateral mobility compared FcγRIIB-I232 was less enriched into microclusters complexes (ICs) after stimulation. However, if sufficient responding time given for...
As the central hub of metabolism machinery, mammalian target rapamycin complex 2 (mTORC2) has been well studied in lymphocytes. an obligatory component mTORC2, role Rictor T cells is established. However, B still remains elusive. involved cell development, especially peripheral development. on receptor (BCR) signaling as underlying cellular and molecular mechanism unknown. This study used cell–specfic knockout (KO) mice to investigate how regulates BCR signaling. We found that key positive...
Pheophorbide a (Pa) from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta shows an important promise in the photodynamic therapy on malignant tumor. The present study investigated that LED-activated Pa induced cellular destruction of colon cancer HT-29 cells. results showed resulted drug-dose dependent photocytotoxicity cells, meaning depends drug concentration (0 – 2 μM). We further apoptosis cells 18 hours after photosensitization using confocal laser scanning microscopy...
The objective of this study was to evaluate the changes in goose embryo transcriptome during feather development. RNA-Sequencing (RNA-Seq) used find profiles follicles from three stages embryonic dorsal skin at day 13, 18, and 28 (E13, E18, E28). results showed that 3001, 6634, 13,780 genes were differently expressed stages. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis revealed differentially (DEGs) E13 vs. E18 significantly mapped into GO term extracellular structure...
A PIP 2 -derived amplification loop fuels the sustained initiation of B cell activation.
Ulcerative colitis (UC) is a recurrent inflammatory disease related to gut microbiota disorder. Metabolites and their sensors play an important role in the communication between microbes host. Our previous study revealed that G protein-coupled receptor 35 (GPR35) key guardian of kynurenic acid (KA) core element defense responses against damage. However, mechanism remains unknown. In this study, DSS-induced rat model was established 16S rRNA sequencing applied explore influence GPR35-mediated...
This work aimed to evaluate some of the probiotic features and safety bacteriocin-producing
This study aims to identify differentially expressed microRNAs (miRNAs) in gastric cancer by comparing cancerous tissues with normal tissues, explore the potential roles.The miRNA expression microarray was employed on and apparently para-cancerous from 3 patients undergoing radical surgery were matched. Quantitative RT-PCR performed other 7 validate findings of microarray. Furthermore, Gene Ontology (GO) analysis enrichment KEGG Pathway for 5 dysregulated candidate miRNAs, including...